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Found 375 with Last Name = 'hertel' and Initial = 'c'
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50247054(6-(3-cyclobutyl-2,3,4,5-tetrahydro-1H-benzo[d]azep...)
Affinity DataKi:  0.120nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]gammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268293((5-(1-cyclobutylpiperidin-4-yloxy)-1-(2,2,2-triflu...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268291((1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268323((5-(1-cyclopropylpiperidin-4-yloxy)-1-(2,2,2-trifl...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50139391((R)-4-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofu...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140558(US8912221, 31)
Affinity DataKi:  0.600nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50159110(1-(3-(4-(piperidin-1-ylmethyl)phenoxy)propyl)piper...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140539(US8912221, 12)
Affinity DataKi:  0.800nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268291((1-(3,4-dichlorophenyl)-5-(1-isopropylpiperidin-4-...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269054((4,4-difluoropiperidin-1-yl)(5-(1-isopropylpiperid...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269053((5-(1-isopropylpiperidin-4-yloxy)-1-(2,2,2-trifluo...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268293((5-(1-cyclobutylpiperidin-4-yloxy)-1-(2,2,2-triflu...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140550(US8912221, 23)
Affinity DataKi:  1nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140552(US8912221, 25)
Affinity DataKi:  1nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140540(US8912221, 13)
Affinity DataKi:  1nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140567(US8912221, 40)
Affinity DataKi:  1.10nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140542(US8912221, 15)
Affinity DataKi:  1.10nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140532(US8912221, 5)
Affinity DataKi:  1.10nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140571(US8912221, 44)
Affinity DataKi:  1.10nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140563(US8912221, 36)
Affinity DataKi:  1.20nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140551(US8912221, 24)
Affinity DataKi:  1.20nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140557(US8912221, 30)
Affinity DataKi:  1.30nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140541(US8912221, 14)
Affinity DataKi:  1.40nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140570(US8912221, 43)
Affinity DataKi:  1.40nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140555(US8912221, 28)
Affinity DataKi:  1.40nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140543(US8912221, 16)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140534(US8912221, 7)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140547(US8912221, 20)
Affinity DataKi:  1.60nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140549(US8912221, 22)
Affinity DataKi:  1.70nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269099(2-(2-(4,4-difluoropiperidine-1-carbonyl)-5-(1-isop...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268947((5-(1-cyclopropylpiperidin-4-yloxy)-1H-indol-2-yl)...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268451(2-(ethoxycarbonyl)-1H-indole-5-carboxylic acid | C...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268323((5-(1-cyclopropylpiperidin-4-yloxy)-1-(2,2,2-trifl...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269098((4,4-difluoropiperidin-1-yl)(1-(4-fluorophenylsulf...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268997((4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperi...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268996((3,3-difluoropiperidin-1-yl)(5-(1-isopropylpiperid...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268947((5-(1-cyclopropylpiperidin-4-yloxy)-1H-indol-2-yl)...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50370569(A-349,821 | A-349821)
Affinity DataKi:  2nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268815((R)-4'-(3-(3-(dimethylamino)pyrrolidin-1-yl)propox...)
Affinity DataKi:  2nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140561(US8912221, 34)
Affinity DataKi:  2.20nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140559(US8912221, 32)
Affinity DataKi:  2.30nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140530(US8912221, 3)
Affinity DataKi:  2.40nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140531(US8912221, 4)
Affinity DataKi:  2.5nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140538(US8912221, 11)
Affinity DataKi:  2.60nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKininogen-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM107177(US8592426, 26)
Affinity DataKi:  2.60nMAssay Description:Binding assay using Bradykinin-1 receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetB1 bradykinin receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM140528(US8912221, 1)
Affinity DataKi:  2.60nMpH: 7.4Assay Description:For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Rattus norvegicus (rat))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50268997((4,4-Difluoropiperidin-1-yl)[5-(1-isopropyl-piperi...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50269097((4,4-difluoropiperidin-1-yl)(5-(1-isopropylpiperid...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKininogen-1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM107189(US8592426, 38)
Affinity DataKi:  3nMAssay Description:Binding assay using Bradykinin-1 receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
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