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TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382333(CHEMBL2023123)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305450(CHEMBL592763 | methyl (S)-4-(3-chlorophenyl)-4-((R...)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305465(CHEMBL589647 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382335(CHEMBL2024249)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382334(CHEMBL1276678)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382333(CHEMBL2023123)
Affinity DataIC50:  0.330nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382331(CHEMBL2024248)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382334(CHEMBL1276678)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305454(CHEMBL591342 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305456(CHEMBL605408 | methyl 2-((R)-((R)-1-((S)-1-amino-3...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382331(CHEMBL2024248)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM29949(piperidine-1-carboxamide, 21l)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305466(CHEMBL592765 | methyl 2-((R)-(3-chloro-5-fluorophe...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.530nMAssay Description:Inhibition of human recombinant renin using H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH as substrate assessed as formation of angiot...More data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382331(CHEMBL2024248)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305457(CHEMBL591340 | methyl 2-((R)-((R)-1-((S)-1-amino-3...)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305453(CHEMBL592762 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.590nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305462(CHEMBL590623 | methyl 2-((R)-(3-chloro-2-fluorophe...)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305461(CHEMBL606238 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305463(CHEMBL590388 | methyl 2-((R)-(5-chloro-2-fluorophe...)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM17950((2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethyle...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350915(CHEMBL1818070)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM29957(piperidine-1-carboxamide, 21t)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of human recombinant renin using DABCYL-gamma-Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate for 60 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305452(CHEMBL591578 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305458(CHEMBL591105 | methyl 2-((R)-(3-chlorophenyl)((R)-...)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14044(Aminofurazanyl-azabenzimidazole 6k | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 22°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14042(Aminofurazanyl-azabenzimidazole 6i | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 22°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14046(Aminofurazanyl-azabenzimidazole 6m | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 22°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14045(Aminofurazanyl-azabenzimidazole 6l | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 22°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline

LigandPNGBDBM14043(Aminofurazanyl-azabenzimidazole 6j | N-(3-{[2-(4-a...)
Affinity DataIC50: <1nMpH: 7.4 T: 22°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382333(CHEMBL2023123)
Affinity DataIC50:  1.06nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350922(CHEMBL1818063)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50382334(CHEMBL1276678)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of renin in human plasma assessed as formation of angiotensin1 product after 90 mins by competitive radioimmunoassayMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350916(CHEMBL1818069)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305455(CHEMBL591341 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  1.17nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350936(CHEMBL1818049)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305465(CHEMBL589647 | methyl 2-((R)-((R)-1-((S)-1-cyclohe...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305441((3R)-3-[(1S)-4-(acetylamino)-1-(3-chlorophenyl)-1-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350930(CHEMBL1818055)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305442((R)-3-((S)-1-(3-chlorophenyl)-1-hydroxy-4-propiona...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of trypsin-activated human recombinant reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50305466(CHEMBL592765 | methyl 2-((R)-(3-chloro-5-fluorophe...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant renin assessed as decrease in plasma renin activity by competitive radioimmunoassay in presence of human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350927(CHEMBL1818058)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50350921(CHEMBL1818064)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human renin using of DABCYL-c-Abu-IleHis-Pro-Phe-His-Leu-Val-Ile-His-Thr-EDANS as substrate after 60 to 360 mins by fluores...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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