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Found 135 with Last Name = 'rosenthal' and Initial = 'd'
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318133((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17,2...)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318123((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17-t...)
Affinity DataKi:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318125((14S)-16-amino-10-cyclohexyl-14-(propan-2-yl)-2-ox...)
Affinity DataKi:  8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318132((14S)-16-amino-10,14-dicyclohexyl-20-methoxy-2-oxa...)
Affinity DataKi:  12nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318124((14S)-16-amino-14-cyclohexyl-10-(oxan-4-yl)-2-oxa-...)
Affinity DataKi:  17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318129(4-[(14S)-16-amino-14-cyclohexyl-11-oxo-2-oxa-10,15...)
Affinity DataKi:  20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318128((14S)-16-amino-10-(oxan-4-yl)-14-(propan-2-yl)-2-o...)
Affinity DataKi:  22nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  31nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318126((15R)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataKi:  186nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318130(4-[(14S)-16-amino-14-cyclohexyl-11-oxo-2-oxa-10,15...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084713(CHEMBL331551 | N-[5-Amino-6-(6-hydroxy-1-pyridin-3...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50015490(CHEMBL438945 | H-YPSKPDNPGEDAPAEDMARYYSALRHYINLITR...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060848(CHEMBL3394751)
Affinity DataIC50:  3.90nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060837(CHEMBL3394744)
Affinity DataIC50:  4.20nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084693(2-(3-Benzenesulfonylamino-pyrrolidin-1-yl)-N-(6-fl...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084712(CHEMBL115896 | N-{4-[(1-Allyl-6-hydroxy-1,2,3,4-te...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318133((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084699(2-Fluoro-N-{4-[(6-hydroxy-1-pyridin-3-ylmethyl-1,2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060843(CHEMBL3394748)
Affinity DataIC50:  8nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060893(CHEMBL3394753)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084698(CHEMBL265104 | N-{4-[(6-Methoxy-1-pyridin-3-ylmeth...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103722(CHEMBL3084802 | N-{4-[5-Amino-1-(3-trifluoromethyl...)
Affinity DataIC50:  10nMAssay Description:Binding affinity of the compound towards human neuropeptide Y receptor type 5 in HEK 293 cell line by using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084701(2-(4-Benzenesulfonylamino-piperidin-1-yl)-N-(6-flu...)
Affinity DataIC50:  10nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084700(4-(Benzenesulfonylamino-methyl)-cyclohexanecarboxy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084707(4-[(2-Fluoro-benzenesulfonylamino)-methyl]-cyclohe...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084704(2-(3-Benzenesulfonylamino-pyrrolidin-1-yl)-N-(6-fl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084703(4-[(2-Fluoro-benzenesulfonylamino)-methyl]-cyclohe...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060844(CHEMBL3394749)
Affinity DataIC50:  14nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50103712(CHEMBL430414 | N-[4-(5-Amino-1-p-tolyl-1H-pyrazol-...)
Affinity DataIC50:  15nMAssay Description:Binding affinity of the compound towards human neuropeptide Y receptor type 5 in HEK 293 cell line by using [125I]-PYY as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318123((14S)-16-amino-10,14-dicyclohexyl-2-oxa-10,15,17-t...)
Affinity DataIC50:  17nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060903(CHEMBL3394756)
Affinity DataIC50:  18nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084709(2-Fluoro-N-{4-[(6-fluoro-1-pyridin-3-ylmethyl-1,2,...)
Affinity DataIC50:  19nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084694(CHEMBL118621 | N-{4-[(1-Allyl-6-fluoro-1,2,3,4-tet...)
Affinity DataIC50:  21nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084692(2-Amino-6-(2-fluoro-benzenesulfonylamino)-hexanoic...)
Affinity DataIC50:  22nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084695(2-Fluoro-N-{4-[(6-methoxy-1-pyridin-3-ylmethyl-1,2...)
Affinity DataIC50:  23nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060846(CHEMBL3394750)
Affinity DataIC50:  26nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084706(2-(3-Benzenesulfonylamino-pyrrolidin-1-yl)-N-(6-fl...)
Affinity DataIC50:  27nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084710(CHEMBL117632 | N-{4-[(6-Fluoro-1-pyridin-3-ylmethy...)
Affinity DataIC50:  27nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060842(CHEMBL3394747)
Affinity DataIC50:  29nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060836(CHEMBL3394743)
Affinity DataIC50:  29nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318131((14S)-16-amino-10,14-dicyclohexyl-20-fluoro-2-oxa-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318127((15S)-17-amino-11,15-dicyclohexyl-2-oxa-11,16,18-t...)
Affinity DataIC50:  34nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060904(CHEMBL3394742)
Affinity DataIC50:  34nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060838(CHEMBL3394745)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50318132((14S)-16-amino-10,14-dicyclohexyl-20-methoxy-2-oxa...)
Affinity DataIC50:  36nMAssay Description:Inhibition of BACE1 assessed as amyloid beta (1-40) productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060897(CHEMBL3394754)
Affinity DataIC50:  37nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
The R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50084705(4-(Benzenesulfonylamino-methyl)-cyclohexanecarboxy...)
Affinity DataIC50:  40nMAssay Description:Inhibition of [125I]-PYY binding to recombinant NPY Y5 receptor on HEK-293 cell membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060863(CHEMBL3394752)
Affinity DataIC50:  41nMAssay Description:Displacement of [125I]-Tyr14-nociceptin from human ORL1 expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
West Chester University

Curated by ChEMBL
LigandPNGBDBM50060841(CHEMBL3394746)
Affinity DataIC50:  47nMAssay Description:Displacement of [3H]DAMGO from human Mu opioid receptor expressed in HEK293 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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