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Found 520 with Last Name = 'lorrain' and Initial = 'ds'
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549891(CHEMBL4790083)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M1 expressed in CHO-K1 cell membranes assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549891(CHEMBL4790083)
Affinity DataKi:  0.840nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M3 expressed in CHO-K1 cell membranes assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549891(CHEMBL4790083)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M4 expressed in CHO-K1 cell membranes assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549891(CHEMBL4790083)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]NMS from human recombinant muscarinic receptor M2 expressed in CHO-K1 cell membranes assessed as inhibition constant incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296979(2-((3R)-3-(4-fluoro-N-methylphenylsulfonamido)-3,4...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335958(2-(2'-(((benzyloxycarbonyl)(ethyl)amino)methyl)-4'...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304887((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549891(CHEMBL4790083)
Affinity DataIC50:  1.58nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M1 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549891(CHEMBL4790083)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M1 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335954(CHEMBL1668898 | Sodium [2'-[(cyclopropanecarbonyl-...)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape change after 4 hrs by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304898((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  1.70nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50322851(CHEMBL1210423 | sodium 3-(3-(tert-butylthio)-1-(4-...)
Affinity DataIC50:  2nMAssay Description:Binding affinity to FLAP in human PMN by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357310(CHEMBL1916710)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357308(CHEMBL1916707)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335954(CHEMBL1668898 | Sodium [2'-[(cyclopropanecarbonyl-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human CYP3A4 by time-dependent inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304903((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  2.20nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304899((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Inception Sciences

Curated by ChEMBL
LigandPNGBDBM50013729(CHEMBL3264919)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Inception Sciences

Curated by ChEMBL
LigandPNGBDBM50013730(CHEMBL3264920)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357307(CHEMBL1916706)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357289(CHEMBL1916708)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357311(CHEMBL1916711)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Inception Sciences

Curated by ChEMBL
LigandPNGBDBM50013734(CHEMBL3264924)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335957(2-(2'-(((benzyloxycarbonyl)(ethyl)amino)methyl)-4'...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304902((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  3.20nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304901((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  3.80nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357310(CHEMBL1916710)
Affinity DataIC50:  4nMAssay Description:Inhibition of human prostanoid DP2 receptor in human whole bood assessed as eosinophil shape change preincubated for 15 mins before addition of PGD2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357309(CHEMBL1916709)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357302(CHEMBL1916699)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357286(CHEMBL1916700)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304882((S)-3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-((1...)
Affinity DataIC50:  4nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296979(2-((3R)-3-(4-fluoro-N-methylphenylsulfonamido)-3,4...)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptor in presence of human serum albuminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335951(2-(2'-((N-ethylcyclopropanecarboxamido)methyl)-6-m...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape change by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357304(CHEMBL1916702)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357303(CHEMBL1916701)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]-PGD2 from human prostanoid DP2 receptor expressed in human 293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304897((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-3-(tert-b...)
Affinity DataIC50:  4.5nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Inception Sciences

Curated by ChEMBL
LigandPNGBDBM50013735(CHEMBL3264925)
Affinity DataIC50:  4.60nMAssay Description:Antagonist activity at human PPAR-alpha assessed as inhibition of GW7647-induced effect after overnight incubation by cell-based luciferase reporter ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304895((S)-3-(5-((1-acetylindolin-2-yl)methoxy)-1-(4-chlo...)
Affinity DataIC50:  4.70nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50366775(BENZTROPINE | Benzatropine)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M4 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357286(CHEMBL1916700)
Affinity DataIC50:  5nMAssay Description:Inhibition of human prostanoid DP2 receptor in human whole bood assessed as eosinophil shape change preincubated for 15 mins before addition of PGD2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357311(CHEMBL1916711)
Affinity DataIC50:  5nMAssay Description:Inhibition of human prostanoid DP2 receptor in human whole bood assessed as eosinophil shape change preincubated for 15 mins before addition of PGD2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335959(2-(2'-(((benzyloxycarbonyl)(ethyl)amino)methyl)-6-...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335954(CHEMBL1668898 | Sodium [2'-[(cyclopropanecarbonyl-...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape change by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549908(CHEMBL4760610)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M1 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Pipeline Therapeutics

Curated by ChEMBL
LigandPNGBDBM50549901(CHEMBL4799006)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at human recombinant muscarinic receptor M1 expressed in CHO-K1 cells assessed as EC80 acetylcholine-induced calcium flux incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50304907((S)-3-(5-((1-acetylpyrrolidin-2-yl)methoxy)-3-(ter...)
Affinity DataIC50:  6nMAssay Description:Binding affinity to FLAP in human PMN derived membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296983((R)-2-(8-(4-fluoro-N-methylphenylsulfonamido)-6,7,...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296977(2-(5-fluoro-2-methyl-3-(quinolin-2-ylmethyl)-1H-in...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50296980((R)-2-(7-(4-fluoro-N-methylphenylsulfonamido)-6,7,...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human prostaglandin D2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Amira Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50335954(CHEMBL1668898 | Sodium [2'-[(cyclopropanecarbonyl-...)
Affinity DataIC50:  6nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor expressed in 293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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