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Found 546 with Last Name = 'bifulco' and Initial = 'g'
TargetHistone deacetylase(Homo sapiens (Human))
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544523(CHEMBL4647674)
Affinity DataIC50:  4.10nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544513(CHEMBL4649088)
Affinity DataIC50:  6.60nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544531(CHEMBL4648953)
Affinity DataIC50:  7.70nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544501(CHEMBL4647444)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544506(CHEMBL4647464)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50:  25nMAssay Description:Inhibition of full length HDAC3 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50544503(CHEMBL4644158)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592161(CHEMBL5198220)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591532(CHEMBL4590950)
Affinity DataIC50:  61nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50:  68nMAssay Description:Inhibition of full length HDAC1 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50544500(CHEMBL4649195)
Affinity DataIC50:  90nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592164(CHEMBL5208212)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591533(CHEMBL4449485)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592165(CHEMBL5198707)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of menthol-induced calcium currents at -60 mV measured fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592161(CHEMBL5198220)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50405790(CHEMBL5284121)
Affinity DataIC50:  150nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591535(CHEMBL5185907)
Affinity DataIC50:  160nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50317647((3S,6S,9S,14aR)-6-((1H-indol-3-yl)methyl)-9-benzyl...)
Affinity DataIC50:  179nMAssay Description:Inhibition of full length HDAC2 expressed in HEK293 cells after 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591533(CHEMBL4449485)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464480(CHEMBL4282628)
Affinity DataIC50:  180nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50544531(CHEMBL4648953)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50405760(CHEMBL5284133)
Affinity DataIC50:  200nMAssay Description:Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  210nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592165(CHEMBL5198707)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  220nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Bos taurus (bovine))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50365328(CHEMBL1955927)
Affinity DataIC50:  250nMAssay Description:Inhibition of bovine pancreas carboxypeptidase A using N-(4-methoxyphenylazoformyl)-phenylalanine as substrate after 5 mins by colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592163(CHEMBL5169807)
Affinity DataIC50:  250nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464484(CHEMBL4290910)
Affinity DataIC50:  260nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592159(CHEMBL5193429)
Affinity DataIC50:  280nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591532(CHEMBL4590950)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592160(CHEMBL5182352)
Affinity DataIC50:  290nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592162(CHEMBL5205458)
Affinity DataIC50:  320nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021461(CHEMBL3289927)
Affinity DataIC50:  370nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591524(CHEMBL5202375)
Affinity DataIC50:  380nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50339570(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50544513(CHEMBL4649088)
Affinity DataIC50:  400nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50061980(CHEMBL3394323)
Affinity DataIC50:  410nMAssay Description:Inhibition of mPGES-1 in interleukin-1beta-stimulated human A549 cells microsomal membranes assessed as reduction in PGE2 formation incubated for 15 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591539(CHEMBL5170803)
Affinity DataIC50:  410nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021468(CHEMBL3289934)
Affinity DataIC50:  420nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591539(CHEMBL5170803)
Affinity DataIC50:  430nMAssay Description:Inhibition of human recombinant sEH assessed as reduction in 6-methoxynaphthaldehyde formation using PHOME as substrate preincubated for 1 min follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591522(CHEMBL4473010)
Affinity DataIC50:  450nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Universiti Kebangsaan Malaysia

Curated by ChEMBL
LigandPNGBDBM50021447(CHEMBL3289926)
Affinity DataIC50:  460nMAssay Description:Inhibition of ovine COX1 using arachidonic acid substrate assessed as PGE2 production ELISA method after 2 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50592164(CHEMBL5208212)
Affinity DataIC50:  490nMAssay Description:Antagonist activity at rat TRPM8 channel transfected in HEK293 cells assessed as inhibition of calcium currents by Fluo-4 NW dye based fluorimetric a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase(Homo sapiens (Human))
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  500nMAssay Description:Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
University Of Salerno

Curated by ChEMBL
LigandPNGBDBM50544523(CHEMBL4647674)
Affinity DataIC50:  500nMAssay Description:Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))TBA
LigandPNGBDBM50464486(CHEMBL4293214)
Affinity DataIC50:  540nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell microsomes using PGH2 as substrate assessed as reduction in PGE2 production preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591534(CHEMBL5199450)
Affinity DataIC50:  570nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21(DE3) assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50591539(CHEMBL5170803)
Affinity DataIC50:  590nMAssay Description:Inhibition of 5-LOX in human PMNL assessed as reduction in all-trans isomers of LTB4 and 5-HETE formation preincubated for 15 mins followed by A23187...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Federico Ii Of Naples

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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