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Found 289 with Last Name = 'hamon' and Initial = 'j'
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436459(CHEMBL2396661)
Affinity DataIC50:  5nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436448(CHEMBL2397186)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436454(CHEMBL2397196)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436451(CHEMBL2397199)
Affinity DataIC50:  12nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436450(CHEMBL2397187)
Affinity DataIC50:  14nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436457(CHEMBL2397193)
Affinity DataIC50:  16nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436452(CHEMBL2397198)
Affinity DataIC50:  16nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436458(CHEMBL2397192)
Affinity DataIC50:  19nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436460(CHEMBL2397191)
Affinity DataIC50:  19nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646438(US11878973, Example 40)
Affinity DataIC50:  20nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646432(US11878973, Example 37)
Affinity DataIC50:  20nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436456(CHEMBL2397194)
Affinity DataIC50:  20nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646481(N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-d...)
Affinity DataIC50:  30nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646458(US11878973, Example 50)
Affinity DataIC50:  30nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646369(US11878973, Example 13)
Affinity DataIC50:  30nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436453(CHEMBL2397197)
Affinity DataIC50:  39nMAssay Description:Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50436448(CHEMBL2397186)
Affinity DataIC50:  39nMAssay Description:Inhibition of N-terminal myristoylated P110alpha (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646427(US11878973, Example 98)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646434(US11878973, Example 38)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646436(US11878973, Example 39)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646440(US11878973, Example 41)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646457(US11878973, Example 113)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646460(US11878973, Example 51)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646462(US11878973, Example 52)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646465(US11878973, Example 117)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646351(US11878973, Example 4)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646356(US11878973, Example 66)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646362(US11878973, Example 69)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646383(US11878973, Example 79)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646391(US11878973, Example 81a)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646393(US11878973, Example 81b)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646409(US11878973, Example 89)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646419(US11878973, Example 94)
Affinity DataIC50:  40nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646374(US11878973, Example 75)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646489(N-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(3,6-d...)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646345(US11878973, Example 1)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646346(US11878973, Example 61)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646399(US11878973, Example 84)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646445(US11878973, Example 107)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646348(US11878973, Example 62)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646372(US11878973, Example 74)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646368(US11878973, Example 72)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646415(US11878973, Example 92)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646354(US11878973, Example 65)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646421(US11878973, Example 95)
Affinity DataIC50:  50nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170206(4-(4'-Acetyl-biphenyl-4-yl)-thiophene-2-carboxylic...)
Affinity DataIC50:  57nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646483(US11878973, Example 134)
Affinity DataIC50:  60nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646474(US11878973, Example 58)
Affinity DataIC50:  60nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [517-1238](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM646463(US11878973, Example 116)
Affinity DataIC50:  60nMAssay Description:The core helicase motif of the WRN protein (aa N517-P1238) was produced for this assay (protein production as described above). A 45 oligonucleotide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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