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Found 249 with Last Name = 'maier' and Initial = 'j'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50526692(CHEMBL1230881)
Affinity DataKi:  146nMAssay Description:Inhibition of wild-type human CHK1 (1 to 289 residues) expressed in baculovirus infected Sf21 insect cells preincubated for 15 mins followed by ATP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188343(4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188342(4-(2,6-dichloro-phenyl)-8-(4-morpholin-4-yl-phenyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195334(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-(diethylamino...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195345(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(4-methylpiperaz...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195351(1-(3-(2,5-dimethylbenzyl)-5-(3-cyclohexylpropyl)ph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188343(4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant Src in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50453891(CHEMBL4214567)
Affinity DataIC50:  3nMAssay Description:Inhibition of human EGFR L858R/T790M mutant (696 to 1022 residues) expressed in Sf9 insect cells by HTRF assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186560(1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186557(1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186535(3-(5-hydroxy-2-methylphenyl)-1-methyl-1-(6-(4-morp...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186566(3-(5-((5-tert-butylisoxazol-3-yl)carbamoyl)-2-meth...)
Affinity DataIC50:  4nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195340(3-(4-(benzo[d]isoxazol-3-yl)pyrimidin-2-ylamino)-4...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201514(2-(3H-imidazo[4,5-c]pyridin-3-yl)-N-methoxy-7-meth...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186556(3-(2,6-dichlorophenyl)-1-methyl-1-(6-(4-(4-methylp...)
Affinity DataIC50:  6nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195354(CHEMBL220924 | N1-(4-(benzo[d]isoxazol-3-yl)pyrimi...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186554(3-(2-chloro-6-methylphenyl)-1-methyl-1-(6-(4-(4-me...)
Affinity DataIC50:  9nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of p38More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188348(4-(2-chloro-5-hydroxy-phenyl)-8-(4-dimethylamino-p...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201503((2-(3H-imidazo[4,5-c]pyridin-3-yl)-7-methyl-4-((S)...)
Affinity DataIC50:  11nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  11nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103004(CHEMBL3394120)
Affinity DataIC50:  12nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of JAK3 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195338(3-(2-(1H-benzo[d]imidazol-1-yl)-6-(2-morpholinoeth...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103129(CHEMBL3394125)
Affinity DataIC50:  17nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201514(2-(3H-imidazo[4,5-c]pyridin-3-yl)-N-methoxy-7-meth...)
Affinity DataIC50:  18nMAssay Description:Inhibition of JAK3 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103104(CHEMBL3394106)
Affinity DataIC50:  18nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201504(CHEMBL233555 | N-(2-(dimethylamino)ethyl)-2-(3H-im...)
Affinity DataIC50:  19nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188357(4-(2,6-dichloro-phenyl)-8-[4-(2-dimethylamino-ethy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201512((2-(3H-imidazo[4,5-c]pyridin-3-yl)-7-methyl-4-((S)...)
Affinity DataIC50:  21nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201503((2-(3H-imidazo[4,5-c]pyridin-3-yl)-7-methyl-4-((S)...)
Affinity DataIC50:  22nMAssay Description:Inhibition of JAK3 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195329(3-(2-(1H-benzo[d]imidazol-1-yl)pyrimidin-4-ylamino...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50102911(CHEMBL3394107)
Affinity DataIC50:  25nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201516(2-(3H-imidazo[4,5-c]pyridin-3-yl)-N-(2-methoxyethy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188352(4-(2,6-dichloro-phenyl)-8-(4-dimethylamino-phenyla...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103006(CHEMBL3394121)
Affinity DataIC50:  26nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186537(3-(2-chloro-6-methylphenyl)-1-(6-(4-(2-(diethylami...)
Affinity DataIC50:  28nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103104(CHEMBL3394106)
Affinity DataIC50:  30nMAssay Description:Inhibition of p38alpha (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50186558(1-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimi...)
Affinity DataIC50:  32nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50102997(CHEMBL3394101)
Affinity DataIC50:  33nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201504(CHEMBL233555 | N-(2-(dimethylamino)ethyl)-2-(3H-im...)
Affinity DataIC50:  34nMAssay Description:Inhibition of JAK3 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103006(CHEMBL3394121)
Affinity DataIC50:  34nMAssay Description:Inhibition of p38alpha (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103010(CHEMBL3394108)
Affinity DataIC50:  35nMAssay Description:Inhibition of JNK3 (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50103129(CHEMBL3394125)
Affinity DataIC50:  36nMAssay Description:Inhibition of p38alpha (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50102919(CHEMBL3394097)
Affinity DataIC50:  36nMAssay Description:Inhibition of p38alpha (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eberhard Karls Universit£T T£Bingen

Curated by ChEMBL
LigandPNGBDBM50102911(CHEMBL3394107)
Affinity DataIC50:  39nMAssay Description:Inhibition of p38alpha (unknown origin) assessed as phosphorylation of ATF-2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201502(2-(3H-imidazo[4,5-c]pyridin-3-yl)-7-methyl-N-(3-mo...)
Affinity DataIC50:  42nMAssay Description:Inhibition of JAK2 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50201506(2-(3H-imidazo[4,5-c]pyridin-3-yl)-7-methyl-N-(meth...)
Affinity DataIC50:  42nMAssay Description:Inhibition of JAK3 by kinase-Glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50188347(4-(2,6-dichloro-phenyl)-8-(4-diethylamino-phenylam...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant Lck in presence of 10 mM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Procter And Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195342(3-(2-(1H-benzo[d]imidazol-1-yl)-6-((1-methylpiperi...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant Lck by ProFlour assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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