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Found 910 with Last Name = 'gerspacher' and Initial = 'm'
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50068974(2,2-Diethyl-N-[3-(7-fluoro-quinolin-2-ylmethoxy)-p...)
Affinity DataIC50:  0.200nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215369(CHEMBL368290)
Affinity DataIC50:  0.300nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215411(CHEMBL425675)
Affinity DataIC50:  0.400nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308093(1-[3-(2-Hydroxy-ethoxy)-benzyl]-4-(4-isopropyl-phe...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50106898(CHEMBL317632 | N-Methyl-N-[(E)-(R)-1-(1-methyl-1H-...)
Affinity DataIC50:  0.5nMAssay Description:In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]-Sar9-substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215410(CHEMBL369421)
Affinity DataIC50:  0.5nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50106901(CHEMBL104954 | N-[(E)-(R)-1-(4-Chloro-benzyl)-3-((...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibition of [3H]-Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50106901(CHEMBL104954 | N-[(E)-(R)-1-(4-Chloro-benzyl)-3-((...)
Affinity DataIC50:  0.5nMAssay Description:In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]-Sar9-substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50115967(2-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]...)
Affinity DataIC50:  0.600nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50115966(4'-Chloro-2-(3,4,5-trimethoxy-benzoylamino)-biphen...)
Affinity DataIC50:  0.700nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089567(CHEMBL35857 | N-[(E)-1-(4-Chloro-benzyl)-3-(2-oxo-...)
Affinity DataIC50:  0.760nMAssay Description:In vitro inhibition of [3H]-Sar9-substance P binding to Tachykinin receptor 1 in bovine retinal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50068987(CHEMBL175119 | N-[3-(7-Chloro-quinolin-2-ylmethoxy...)
Affinity DataIC50:  0.800nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50403920(CHEMBL2112212)
Affinity DataIC50:  0.800nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50068980(2,2-Diethyl-N-[3-(quinolin-2-ylmethoxy)-phenyl]-su...)
Affinity DataIC50:  0.900nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145270(CHEMBL81994 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia-...)
Affinity DataIC50:  1nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50106899(CHEMBL105600 | N-[(E)-(R)-3-(1-Carbamoyl-cyclohexy...)
Affinity DataIC50:  1nMAssay Description:In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]-Sar9-substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50403918(CHEMBL2113739)
Affinity DataIC50:  1nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50115965(2-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]...)
Affinity DataIC50:  1nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215370(CHEMBL174265)
Affinity DataIC50:  1nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50106900(CHEMBL103979 | N-Methyl-N-[(E)-(R)-1-naphthalen-2-...)
Affinity DataIC50:  1.10nMAssay Description:In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]-Sar9-substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308090(1-(3-Ethoxy-4-methoxy-benzyl)-4-(4-isopropyl-pheny...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215372(CHEMBL175419)
Affinity DataIC50:  1.40nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50106891(3-[N'-(3,5-Bis-trifluoromethyl-benzoyl)-N-(3,4-dic...)
Affinity DataIC50:  1.40nMAssay Description:In vitro binding affinity for Tachykinin receptor 1 of bovine retinal membranes using [3H]-Sar9-substance P as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50115959(2-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]...)
Affinity DataIC50:  1.5nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308081(4-(4-Isopropyl-phenyl)-1-(4-methyl-benzyl)-6-propa...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325523(2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308087(4-(4-Isopropyl-phenyl)-1-(3-methyl-benzyl)-6-propa...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325525(2-((2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyet...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145244(CHEMBL82158 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia-...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145235(CHEMBL432169 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145289(CHEMBL312362 | {4-[(9-Fluoro-5,6-dihydro-4H-3-thia...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145280(CHEMBL84453 | Cyclopropyl-{4-[(9-fluoro-5,6-dihydr...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145279(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145252(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215394(CHEMBL368666)
Affinity DataIC50:  2nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215399(CHEMBL174575)
Affinity DataIC50:  2nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145266(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145282(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145277(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308103(CHEMBL590539 | N-{3-[4-(4-Isopropyl-pheny)-2-oxo-6...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308108(1-Benzyl-5-cyclopropylmethyl-6-hydroxy-4-(4-isopro...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325524(2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308089(1-(3-Methoxy-benzyl)-4-(4-isopropyl-phenyl)-6-prop...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50403916(CHEMBL2113740)
Affinity DataIC50:  2.70nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Rat 6B)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145232(CHEMBL311229 | {4-[(9-Methyl-4,5-dihydro-6-oxa-3-t...)
Affinity DataIC50:  2.90nMAssay Description:In vitro binding affinity of the compound against rat neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50215397(CHEMBL173523)
Affinity DataIC50:  3nMAssay Description:In vitro for antagonistic activity against LTD4 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50089060(CHEMBL273597 | Naphthalene-1-sulfonic acid [4-(4-a...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145243(CHEMBL83830 | N,N-dimethyl-N'-({4-[(19-Fluoro-2-me...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50115957(2-[(3,5-Bis-trifluoromethyl-benzoyl)-methyl-amino]...)
Affinity DataIC50:  3nMAssay Description:inhibition of [3H]-Sar-SP binding to Tachykinin receptor 1 of bovine retina membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50145256(1-{4-[(9-Fluoro-5,6-dihydro-4H-3-thia-1-aza-benzo[...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity of the compound against human neuropeptide Y5 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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