BindingDB PrimarySearch_ki

Found 666 with Last Name = 'schimpl' and Initial = 'm'

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413448(9-((1r,4r)-4-hydroxycyclohexyl)-7-methyl-2-((7-met...)

IC50: 0.0794nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599239(CHEMBL5184141 | US11884671, Example 32)

IC50: <0.100nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599238(CHEMBL5181303 | US11884671, Example 29)

IC50: <0.100nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599237(CHEMBL5180090 | US11884671, Example 30)

IC50: 0.120nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599240(CHEMBL5194436 | US11884671, Example 31)

IC50: 0.130nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413460(9-cyclohexyl-7-methyl-2-((7-methyl-[1,2,4]triazolo...)

IC50: 0.158nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526936(CHEMBL4450232)

IC50: 0.200nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526938(CHEMBL4553941)

IC50: 0.251nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413456(9-((1r,4r)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)

IC50: 0.316nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526928(CHEMBL4555040)

IC50: 0.316nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599247(CHEMBL5197250)

IC50: 0.370nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526932(CHEMBL4474647)

IC50: 0.398nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413457(9-((1s,4s)-4-hydroxy-4-methylcyclohexyl)-7-methyl-...)

IC50: 0.398nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599234(CHEMBL5170489 | US11884671, Example 52)

IC50: 0.510nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.600nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.600nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.631nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599248(CHEMBL5179972)

IC50: 0.640nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599243(CHEMBL5192430 | US11884671, Example 37)

IC50: 0.690nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599242(CHEMBL5196848 | US11884671, Example 45)

IC50: 0.690nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM413450(7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridi...)

IC50: 0.700nMAssay Description:Inhibition of AlexaFluor-labeled tracer 236 binding to human untagged DNA-PK expressed in baculovirus expression system measured after 60 mins by Lan...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599245(CHEMBL5191577)

IC50: 0.75nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50563635(CHEMBL4777640)

IC50: 0.794nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599251(CHEMBL5198414 | US11884671, Example 42)

IC50: 1.40nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50573136(CHEMBL4875486)

IC50: 1.60nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50172077(CHEMBL3810063)

IC50: 1.60nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599250(CHEMBL5178837)

IC50: 1.70nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599246(CHEMBL5204870)

IC50: 1.70nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526941(CHEMBL4459057)

IC50: 2nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50573135(CHEMBL4873217)

IC50: 2nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526933(CHEMBL4438672)

IC50: 2.5nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50573128(CHEMBL4865752)

IC50: 2.5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599244(CHEMBL5182028 | US11884671, Example 41)

IC50: 2.60nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599249(CHEMBL5182752)

IC50: 2.70nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50599236(CHEMBL5186637 | US11884671, Example 44)

IC50: 2.90nMAssay Description:Inhibition of DNA-PK (unknown origin) using EPPLSQEAFADLWKK peptide as substrate preincubated with compound for 30 mins followed by substrate additio...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM553937(US11325906, Example 1)

IC50: 3nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM553940(US11325906, Example 4)

IC50: 3nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase PC cid PC sid

Tyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50172077(CHEMBL3810063)

IC50: 3.20nMAssay Description:Inhibition of GST-tagged AXL (unknown origin) (464 to 485 residues) using Axltide (CKKSRGDYMTMQJG-acid) peptide as substrate preincubated for 30 mins...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

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Details Article PubMed

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50563640(CHEMBL4746916)

IC50: 3.20nMAssay Description:Inhibition of His6/TEV fused-GST-tagged Flt3 (unknown origin) (H564 to S993 residues) using Axltide (CKKSRGDYMTMQJ-acid) peptide as substrate preincu...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50573130(CHEMBL4855381)

IC50: 3.20nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526931(CHEMBL4474502)

IC50: 3.20nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50563644(CHEMBL4782810)

IC50: 4nMAssay Description:Inhibition of GST-tagged AXL (unknown origin) (464 to 485 residues) using Axltide (CKKSRGDYMTMQJG-acid) peptide as substrate preincubated for 30 mins...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50601780(CHEMBL5202060)

IC50: 4nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50601781(CHEMBL5197101)

IC50: 5nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details PubMed PDB

3D Structure (crystal)

Poly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM553947(US11325906, Example 11)

IC50: 5nMAssay Description:Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526937(CHEMBL4483014)

IC50: 5nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50563643(CHEMBL4754609)

IC50: 5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50526935(CHEMBL4529390)

IC50: 5nMAssay Description:Inhibition of human HeLa cell-derived full length DNA-PK catalytic subunit using fluorescein-EPPLSQEAFADLWKK as substrate preincubated for 30 mins fo...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50563642(CHEMBL4746146)

IC50: 5nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Tyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50563643(CHEMBL4754609)

IC50: 5nMAssay Description:Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Displayed 1 to 50 (of 666 total ) | Next | Last >>

Filter my 666 hits

Targets 51▿
- Receptor-type tyrosine-protein kinase FLT3 96
- ATPase family AAA domain-containing protein 2 86
- DNA-dependent protein kinase catalytic subunit 78
- Tyrosine-protein kinase receptor UFO 72
- Tyrosine-protein kinase Mer 47
- Potassium voltage-gated channel subfamily H member 2 41
- S-adenosylmethionine synthase isoform type-2 37
- Tyrosine-protein kinase receptor TYRO3 30
- Poly [ADP-ribose] polymerase 2 30
- Poly [ADP-ribose] polymerase 1 30
- Bromodomain-containing protein 4 26
- Poly [ADP-ribose] polymerase tankyrase-1 9
- Protein mono-ADP-ribosyltransferase PARP10 6
- Protein mono-ADP-ribosyltransferase PARP4 5
- Protein mono-ADP-ribosyltransferase PARP16 5
- Protein arginine N-methyltransferase 5 4
- Protein mono-ADP-ribosyltransferase PARP3 4
- Cytochrome P450 1A2 4
- Cytochrome P450 3A4 4
- Protein mono-ADP-ribosyltransferase PARP14 3
- Dual specificity protein kinase TTK 3
- Protein mono-ADP-ribosyltransferase PARP12 3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 3
- Protein mono-ADP-ribosyltransferase PARP8 3
- Macrophage colony-stimulating factor 1 receptor 3
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Serine-protein kinase ATM 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Protein mono-ADP-ribosyltransferase PARP11 2
- Bromodomain-containing protein 2 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Poly [ADP-ribose] polymerase tankyrase-2 2
- Serine/threonine-protein kinase ATR 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- 3-phosphoinositide-dependent protein kinase 1 1
- ATPase family AAA domain-containing protein 2B 1
- Bromodomain-containing protein 3 1
- Bromodomain and WD repeat-containing protein 1 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Nucleosome-remodeling factor subunit BPTF 1
- Histone acetyltransferase p300 1
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Chromatin remodeling regulator CECR2 1
- Protein polybromo-1 1
- Histone acetyltransferase KAT2B 1
- Cytochrome P450 4B1 1
- Bromodomain testis-specific protein 1
- Protein mono-ADP-ribosyltransferase PARP9 1
- Transcription initiation factor TFIID subunit 1 1
- Probable global transcription activator SNF2L2 1
- Bromodomain-containing protein 9 1
- ...
Publications 8▿
- J Med Chem 64: 13524-13539 (2021) 159
- J Med Chem 65: 3306-3331 (2022) 126
- J Med Chem 64: 14498-14512 (2021) 122
- J Med Chem 64: 3165-3184 (2021) 86
- J Med Chem 63: 3461-3471 (2020) 61
- ACS Med Chem Lett 13: 1295-1301 (2022) 58
- J Med Chem 64: 6814-6826 (2021) 53
- J Med Chem 61: 8797-8810 (2018) 1
Institutions 1▿
- Astrazeneca 666
Affinity: 0.079 to 1.3E+7 nM▿
- IC50 600
- Kd 66
- Affinity ≤ nM
Xtal structures: 36
Docked structures: 0
Catalog Cmpds: 14