Compile Data Set for Download or QSAR
maximum 50k data
Found 200 with Last Name = 'clasby' and Initial = 'mc'
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222015((1R,3aR,4aS,8aS,9S,9aS)-decahydro-1-methyl-3-oxo-9...)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202073((3R,3aS,4S,4aR,7R,8aR,9aR)-decahydro-7-hydroxy-3-m...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50179567((+)-(3R,3aS,4S,4aR,8aS,9aR)-4-(2-(6-hydroxyquinoli...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212443((3aR,4R,9aS,E)-7,8-difluoro-4-(2-(5-(3-fluoropheny...)
Affinity DataIC50:  7nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212440((3aR,4R,9aS,E)-4-(2-(5-(3-fluorophenyl)pyridin-2-y...)
Affinity DataIC50:  7.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212436((3aR,4R,9aS,E)-7-fluoro-4-(2-(5-(3-fluorophenyl)py...)
Affinity DataIC50:  7.60nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222017(1R,3aR,4aS,8aS,9S,9aS)-6-(cyclopropylcarbonyl)-9-[...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222041((1R,3aR,4aS,8aS,9S,9aS)-ethyl decahydro-1-methyl-3...)
Affinity DataIC50:  8nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212430((3aR,4R,9aS,E)-6-fluoro-4-(2-(5-(3-fluorophenyl)py...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150291(US8987242, 105)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212453((3aR,4R,9aS,E)-4-(2-(5-(3-chlorophenyl)pyridin-2-y...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212429((3aR,4R,9aS,E)-4-(2-(5-(3-(trifluoromethyl)phenyl)...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222015((1R,3aR,4aS,8aS,9S,9aS)-decahydro-1-methyl-3-oxo-9...)
Affinity DataIC50:  10.5nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50173419((3R,3aS,4S,4aR,8aS,9aR)-3-Methyl-4-{(E)-2-[5-(3-tr...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222030((1R,3aR,4aS,8aS,9S,9aS)-decahydro-1-methyl-3-oxo-9...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202078((3R,3aS,4S,4aR,8aR,9aR)-7,7-difluoro-decahydro-3-m...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202082((3R,3aS,4S,4aR,8aR,9aR)-7,7-difluoro-decahydro-3-m...)
Affinity DataIC50:  12nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212445((3aS,4S,9aR,E)-4-(2-(6-methoxyquinolin-2-yl)vinyl)...)
Affinity DataIC50:  12.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212438((3aR,4R,9aS,E)-4-(2-(5-(3-chlorophenyl)pyridin-2-y...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222026((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(2-chloropheny...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150295(US8987242, aa144)
Affinity DataIC50:  13nMpH: 8.0 T: 2°CAssay Description:Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212437((3aR,4R,9aS,E)-4-(2-(5-(3-chlorophenyl)pyridin-2-y...)
Affinity DataIC50:  14.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212441((3aR,4R,9aS,E)-6-chloro-4-(2-(5-(3-fluorophenyl)py...)
Affinity DataIC50:  14.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50179569((+/-)-(3R,3aS,4S,4aR,8aS,9aR)-4-(2-(6-methoxyquino...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50179569((+/-)-(3R,3aS,4S,4aR,8aS,9aR)-4-(2-(6-methoxyquino...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202064((3R,3aS,4S,4aR,8aR,9aR)-7,7-difluoro-decahydro-3-m...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222022((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(3-fluoropheny...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222043((1R,3aR,4aS,8aS,9S,9aS)-6-(cyclopropylcarbonyl)-9-...)
Affinity DataIC50:  15.5nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212439((3aR,4R,9aS,E)-4-(2-(5-(3-chlorophenyl)pyridin-2-y...)
Affinity DataIC50:  15.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222032((1R,3aR,4aS,8aS,9S,9aS)-2-methoxyethyl 9-[(e)-2-[5...)
Affinity DataIC50:  16.5nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202067((3R,3aS,4S,4aR,7R,8aR,9aR)-decahydro-7-hydroxy-3-m...)
Affinity DataIC50:  16.5nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222031((1R,3aR,4aS,8aS,9S,9aS)-decahydro-1-methyl-9-[(e)-...)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202073((3R,3aS,4S,4aR,7R,8aR,9aR)-decahydro-7-hydroxy-3-m...)
Affinity DataIC50:  17nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222034((1R,3aR,4aS,8aS,9S,9aS)-N-ethyl-dodecahydro-1-meth...)
Affinity DataIC50:  18.5nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222013((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(3-chloropheny...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150286(US8987242, 62)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150285(US8987242, 50)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM150289(US8987242, 15)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212435((3aR,4R,9aS,E)-8-fluoro-4-(2-(5-(3-fluorophenyl)py...)
Affinity DataIC50:  20.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222018((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(2,3-dichlorop...)
Affinity DataIC50:  21nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50212431((3aR,4R,9aS,E)-6,8-difluoro-4-(2-(5-(3-(trifluorom...)
Affinity DataIC50:  21.5nMAssay Description:Displacement of [3H]haTRAP from PAR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222042((1R,3aR,4aS,8aS,9S,9aS)-decahydro-1-methyl-9-[(1E)...)
Affinity DataIC50:  22nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202079((3R,3aS,4S,4aR,7S,8aR,9aR)-decahydro-7-hydroxy-3-m...)
Affinity DataIC50:  23nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222039((1R,3aR,4aS,8aS,9S,9aS)-phenylmethyl decahydro-1-m...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50179581((+)-2-(2-(2-((3R,3aS,4S,4aR,8aS,9aR)-3-methyl-1-ox...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222019((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(2-fluoropheny...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222016((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(3-fluoropheny...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50543904(CHEMBL4648414)
Affinity DataIC50:  26nMAssay Description:Inhibition of activated factor IX (unknown origin) using CH3SO2-D-CHG-Gly-Arg-pNA:AcOH as substrate by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50222035((1R,3aR,4aS,8aS,9S,9aS)-9-[(E)-2-[5-(2,3-difluorop...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50202074((3R,3aS,4S,4aR,7R,8aR,9aR)-decahydro-7-hydroxy-3-m...)
Affinity DataIC50:  28nMAssay Description:Displacement of [3H]haTRAP from PAR1 in human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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