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Found 302 with Last Name = 'plobeck' and Initial = 'n'
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  0.230nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092669(CHEMBL129420 | N,N-Diethyl-4-(piperazin-1-yl-quino...)
Affinity DataIC50:  0.510nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092704(CHEMBL339898 | N,N-Diethyl-4-[piperidin-4-ylidene-...)
Affinity DataIC50:  0.630nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092711(CHEMBL339457 | N,N-Diethyl-4-[(3-fluoro-phenyl)-pi...)
Affinity DataIC50:  0.740nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092703(4-[(3-Acetyl-phenyl)-piperidin-4-ylidene-methyl]-N...)
Affinity DataIC50:  0.860nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092710(CHEMBL415521 | N,N-Diethyl-4-(phenyl-piperidin-4-y...)
Affinity DataIC50:  0.870nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092701(CHEMBL278078 | N,N-Diethyl-4-[(2-methoxy-phenyl)-p...)
Affinity DataIC50:  0.970nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092712(CHEMBL126370 | N,N-Diethyl-4-[(2-fluoro-phenyl)-pi...)
Affinity DataIC50:  1nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092716(CHEMBL340131 | N,N-Diethyl-4-[(3-nitro-phenyl)-pip...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092664(CHEMBL126819 | N,N-Diethyl-4-(piperazin-1-yl-quino...)
Affinity DataIC50:  1.10nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092676(4-[(2,2-Dimethyl-2,3-dihydro-benzofuran-7-yl)-pipe...)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092717(CHEMBL129034 | N,N-Diethyl-4-(naphthalen-1-yl-pipe...)
Affinity DataIC50:  1.20nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039029((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092706(CHEMBL423694 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092715(CHEMBL339922 | N,N-Diethyl-4-[(4-methoxy-phenyl)-p...)
Affinity DataIC50:  2nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092714(CHEMBL126141 | N,N-Diethyl-4-{[1-(3-methyl-but-2-e...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50039026(4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092702(CHEMBL129693 | N,N-Diethyl-4-[(4-methylsulfanyl-ph...)
Affinity DataIC50:  2.10nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092719(4-[(3,4-Dichloro-phenyl)-piperidin-4-ylidene-methy...)
Affinity DataIC50:  2.30nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092680(CHEMBL125734 | N,N-Diethyl-4-(naphthalen-1-yl-pipe...)
Affinity DataIC50:  2.40nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092698(4-[(3-Amino-phenyl)-piperidin-4-ylidene-methyl]-N,...)
Affinity DataIC50:  2.60nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092720(CHEMBL129315 | N,N-Diethyl-4-(piperidin-4-ylidene-...)
Affinity DataIC50:  2.90nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092700(4-[(1-Allyl-piperidin-4-ylidene)-phenyl-methyl]-N,...)
Affinity DataIC50:  3nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178827((+)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyri...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178827((+)-N-(4-(2-(4-fluorophenylamino)pyridin-4-yl)pyri...)
Affinity DataIC50:  3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092683(CHEMBL126366 | N,N-Diethyl-4-(isoquinolin-5-yl-pip...)
Affinity DataIC50:  4.10nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092709(4-[(4-Chloro-phenyl)-piperidin-4-ylidene-methyl]-N...)
Affinity DataIC50:  4.20nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092665(CHEMBL340834 | N,N-Diethyl-4-[(3-fluoro-phenyl)-pi...)
Affinity DataIC50:  4.5nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178843((3R)-1-acetyl-N-(4-(2-(4-fluorophenylamino)pyridin...)
Affinity DataIC50:  5nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178830(CHEMBL205078 | N-(4-(2-(4-fluorophenylamino)pyridi...)
Affinity DataIC50:  6nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092718(4-[(1-Butyl-piperidin-4-ylidene)-phenyl-methyl]-N,...)
Affinity DataIC50:  6.5nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50023913(CHEMBL2112649)
Affinity DataIC50:  6.80nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178832(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092673(CHEMBL126223 | N,N-Diethyl-4-(naphthalen-2-yl-pipe...)
Affinity DataIC50:  7.60nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419871(CHEMBL1957483)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of BACE-1-mediated sAPPbeta production in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178836(CHEMBL203059 | N-(4-(2-(phenylamino)pyridin-4-yl)p...)
Affinity DataIC50:  8nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092661(CHEMBL127638 | N,N-Diethyl-4-[(4-methoxy-phenyl)-p...)
Affinity DataIC50:  8.10nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092681(CHEMBL127434 | N,N-Diethyl-4-[(3-methoxy-phenyl)-(...)
Affinity DataIC50:  8.40nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092688(CHEMBL128005 | N,N-Diethyl-4-(piperazin-1-yl-p-tol...)
Affinity DataIC50:  8.40nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092668(CHEMBL126382 | N,N-Diethyl-4-(phenyl-piperidin-4-y...)
Affinity DataIC50:  8.80nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092668(CHEMBL126382 | N,N-Diethyl-4-(phenyl-piperidin-4-y...)
Affinity DataIC50:  8.80nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178846(1-acetyl-N-(4-(2-(phenylamino)pyridin-4-yl)pyridin...)
Affinity DataIC50:  9nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50092708(4-[(1-Cyclopropylmethyl-piperidin-4-ylidene)-pheny...)
Affinity DataIC50:  9.40nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Astrazeneca R&D SöDertäLje

Curated by ChEMBL
LigandPNGBDBM50178842((3S)-1-acetyl-N-(4-(2-(4-fluorophenylamino)pyridin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50084251(CHEMBL338980 | N,N-Diethyl-4-(phenyl-piperazin-1-y...)
Affinity DataIC50:  11nMAssay Description:Binding affinity on cloned opioid receptor delta 1 in human HEK293S cells using [125I]-[D-Ala2]-deltorphin II as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca R&D Montreal

Curated by ChEMBL
LigandPNGBDBM50084251(CHEMBL338980 | N,N-Diethyl-4-(phenyl-piperazin-1-y...)
Affinity DataIC50:  11nMAssay Description:Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419858(CHEMBL1957481)
Affinity DataIC50:  13nMAssay Description:Inhibition of BACE-1-mediated sAPPbeta production in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419864(CHEMBL1957476)
Affinity DataIC50:  13nMAssay Description:Inhibition of BACE-1-mediated sAPPbeta production in human SH-SY5Y cells after 16 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50419863(CHEMBL1957475)
Affinity DataIC50:  14nMAssay Description:Inhibition of human BACE-1 using (Eu)CEVNLDAEFK(Qsy7) as substrate preincubated for 10 mins prior substrate addition measured after 15 mins by FRET-b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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