Compile Data Set for Download or QSAR
maximum 50k data
Found 629 with Last Name = 'traxler' and Initial = 'p'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3014(3-((3-Hydroxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  1nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3029(3-(4-Aminophenyl)-4-((3-chlorophenyl)amino)-1H-pyr...)
Affinity DataIC50:  2nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3023(3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  2nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3027(3-(3-Aminophenyl)-4-((3-chlorophenyl)amino)-1H-pyr...)
Affinity DataIC50:  5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3016(3-((4-Aminophenyl)amino)-4-((3-chlorophenyl)amino)...)
Affinity DataIC50:  5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  6nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50051308((3-Chloro-phenyl)-(9H-pyrimido[4,5-b]indol-4-yl)-a...)
Affinity DataIC50:  6nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3532(CHEMBL540068 | CHEMBL7917 | N-(3-chlorophenyl)-6,7...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3025(3-(4-Hydroxyphenyl)-4-((3-chlorophenyl)amino)pyraz...)
Affinity DataIC50:  6nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3021(3-((4-Methoxybenzyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  7nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3018(3-(Benzylamino)-4-((3-chlorophenyl)amino)-1H-pyraz...)
Affinity DataIC50:  7nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3013(3-((3-Methoxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3020(3-((3-Methoxybenzyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3012(3-((4-Hydroxyphenyl)amino)-4-((3-chlorophenyl)amin...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)
Affinity DataIC50:  8nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50074743(3-(3-Chloro-phenyl)-5,7-dihydroxy-1H-quinolin-4-on...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Epidermal growth factor receptor-dependent phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287090(4-Chloro-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50051302((3-Chloro-phenyl)-(5-methyl-6-phenyl-7H-pyrrolo[2,...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50175491(4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3022(4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 23...)
Affinity DataIC50:  19nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50051312((3-Bromo-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]py...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3019(3-((3-Chlorobenzyl)amino)-4-((3-chlorophenyl)amino...)
Affinity DataIC50:  26nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3023(3-{4-[(3-chlorophenyl)amino]-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  26nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50051317((3-Chloro-phenyl)-(5,6-dimethyl-7H-pyrrolo[2,3-d]p...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50051297((3-Chloro-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3017(3-((4-(Dimethylamino)phenyl)amino)-4-((3-chlorophe...)
Affinity DataIC50:  29nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4876(1-(3,4-Dichloroanilino)-4-(4-pyridylmethyl)phthala...)
Affinity DataIC50:  30nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3011(3-((4-Methoxyphenyl)-amino)-4-((3-chlorophenyl)ami...)
Affinity DataIC50:  30nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals

LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  30nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3008(3,4-Bis((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]p...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4851((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Affinity DataIC50:  37nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3026(3-(3-Nitrophenyl)-4-((3-chlorophenyl)amino)-1H-pyr...)
Affinity DataIC50:  37nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50074744(3-(3-Chloro-phenyl)-5-hydroxy-7-methoxy-1H-quinoli...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4871(1-(3-Methylanilino)-4-(4-pyridylmethyl)phthalazine...)
Affinity DataIC50:  40nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4878(1-(3,5-Dimethylanilino)-4-(4-pyridylmethyl)phthala...)
Affinity DataIC50:  40nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50051306((3-Bromo-phenyl)-(6,7,8,9-tetrahydro-5H-pyrimido[4...)
Affinity DataIC50:  46nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287091(CHEMBL20252 | Naphthalene-2-carboxylic acid [4-met...)
Affinity DataIC50:  50nMAssay Description:Inhibition of tyrosine kinase(PDGF-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50007064(2-Hydroxy-4-[4-(2-nitro-vinyl)-phenoxysulfonyl]-be...)
Affinity DataIC50:  54nMAssay Description:Inhibition of the epidermal growth factor receptor expressed in A431 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3006(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Affinity DataIC50:  58nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4853(1-(4-Chlorophenoxy)-4-(4-pyridylmethyl)phthalazine...)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4870(1-Anilino-4-(4-pyridylmethyl)phthalazine Dihydroch...)
Affinity DataIC50:  60nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50074742(CHEMBL7866 | [3-(3-Chloro-phenyl)-5-hydroxy-7-meth...)
Affinity DataIC50:  64nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4876(1-(3,4-Dichloroanilino)-4-(4-pyridylmethyl)phthala...)
Affinity DataIC50:  70nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4854(1-(4-Chlorophenylsulfanyl)-4-(4-pyridylmethyl)phth...)
Affinity DataIC50:  70nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4851((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Affinity DataIC50:  77nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4871(1-(3-Methylanilino)-4-(4-pyridylmethyl)phthalazine...)
Affinity DataIC50:  80nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM4875(1-(3-Hydroxyanilino)-4-(4-pyridylmethyl)phthalazin...)
Affinity DataIC50:  80nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM3007(3-((3-Chlorophenyl)amino)-4-(phenylamino)-1H-pyraz...)
Affinity DataIC50:  84nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM50074745(3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one | ...)
Affinity DataIC50:  95nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 629 total ) | Next | Last >>
Jump to: