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Found 252 with Last Name = 'johnston' and Initial = 'r'
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456028(CHEMBL2028993)
Affinity DataKi:  0.00400nMAssay Description:Inhibition constant for binding with thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50451005(CHEMBL290376 | DuP-714)
Affinity DataKi:  0.0410nMAssay Description:Inhibition constant for binding with thrombin was determinedMore data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143115(3-Phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3...)
Affinity DataKi:  0.330nMAssay Description:Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456027(CHEMBL2028992)
Affinity DataKi:  0.400nMAssay Description:Inhibition constant for binding with thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143115(3-Phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity to recombinant human GABA-A alpha3beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50162235(6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]Ro15-1788 from recombinant human GABA-A alpha5beta3gamma2 receptor expressed in mouse L(tk-) cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143115(3-Phenyl-6-(pyridin-2-ylmethoxy)-[1,2,4]triazolo[3...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50156083(3-tert-Butyl-7-(5-methyl-isoxazol-3-yl)-2-(2-methy...)
Affinity DataKi:  3nMAssay Description:Inverse agonist activity at recombinant human GABA-A alpha5beta3gamma2 receptor expressed in mouse L(tk-) cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456029(CHEMBL2028996)
Affinity DataKi:  3.30nMAssay Description:Inhibition constant for binding with thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50456030(CHEMBL2028995)
Affinity DataKi:  4.30nMAssay Description:Inhibition constant for binding with thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50162235(6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03...)
Affinity DataKi:  12nMAssay Description:Binding affinity to recombinant human GABA-A alpha3beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048025(CHEMBL53163 | Gly-boroArg-OH)
Affinity DataKi:  26nMAssay Description:Inhibition constant for binding with thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143106(6-Benzyloxy-3-phenyl-[1,2,4]triazolo[3,4-a]phthala...)
Affinity DataKi:  38nMAssay Description:Binding affinity to recombinant human GABA-A alpha5beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143106(6-Benzyloxy-3-phenyl-[1,2,4]triazolo[3,4-a]phthala...)
Affinity DataKi:  41nMAssay Description:Binding affinity to recombinant human GABA-A alpha3beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50162235(6-phenyl-4,5,7,8-tetraazatetracyclo[9.2.2.02,10.03...)
Affinity DataKi:  71nMAssay Description:Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50143106(6-Benzyloxy-3-phenyl-[1,2,4]triazolo[3,4-a]phthala...)
Affinity DataKi:  280nMAssay Description:Binding affinity to recombinant human GABA-A alpha1beta3gamma2 receptor expressed in L(tk) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-related protein A1(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant A1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 2(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant BCL-w by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant MCL1 by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant BCL-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 10 [11-204](Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50376902(CHEMBL408194)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of BH3 peptide binding to human recombinant BCL-b by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM528351(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-3- ethyl...)
Affinity DataIC50:  0.214nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528352(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-isopropy...)
Affinity DataIC50:  0.260nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528349(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-2,3- dim...)
Affinity DataIC50:  0.343nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528331(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-methylpy...)
Affinity DataIC50:  0.366nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528352(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-isopropy...)
Affinity DataIC50:  0.396nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528349(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-2,3- dim...)
Affinity DataIC50:  0.400nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528331(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-methylpy...)
Affinity DataIC50:  0.406nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528351(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-3- ethyl...)
Affinity DataIC50:  0.419nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528355(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-2-methylpy...)
Affinity DataIC50:  0.816nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  0.928nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  0.996nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528355(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-2-methylpy...)
Affinity DataIC50:  1.13nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528334(US11180503, Example 4 | US11180503, Example 4a | U...)
Affinity DataIC50:  1.49nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsoform A of Ketohexokinase (Peripheral)(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518444((2S,3R)-2-Methyl-1-[4-[1-(1-methylazetidin-3-yl)py...)
Affinity DataIC50:  1.59nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528352(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-isopropy...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528350(5-butyl-3-ethyl-9-(1-methylcyclopropyl)pyrido[3,2-...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528349(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-2,3- dim...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528348(5-butyl-3-methyl-9-(1-methylcyclopropyl)pyrido[3,2...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528334(US11180503, Example 4 | US11180503, Example 4a | U...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528334(US11180503, Example 4 | US11180503, Example 4a | U...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528333(9-([1,1'- Bi(cyclopropan)]- 1-yl)-3- methyl-5- pro...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528332(5-Butyl-3- methyl-9-(1- (trifluoromethyl) cyclopro...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528351(9-([1,1'- Bi(cyclopropan)]-1- yl)-5-butyl-3- ethyl...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528354(5-Butyl-3- (hydroxymethyl)-9- (1- methylcyclopropy...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528353(9-([1,1'-bi(cyclopropan)]-1-yl)-5-butyl-3-((2-(tri...)
Affinity DataIC50:  2nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528347(9-([1,1'-bi(cylopropan)]-1-yl)-5-(cyclopropylmethy...)
Affinity DataIC50:  2.41nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM528333(9-([1,1'- Bi(cyclopropan)]- 1-yl)-3- methyl-5- pro...)
Affinity DataIC50:  2.59nMAssay Description:PDE1B, PDE1A, and PDE1C are cloned and purified following standard protein generation procedures. The assay buffer is prepared to give a final concen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKetohexokinase(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM518444((2S,3R)-2-Methyl-1-[4-[1-(1-methylazetidin-3-yl)py...)
Affinity DataIC50:  2.63nMAssay Description:The intrinsic potency for inhibition of KHK C or A activity may be measured using an enzymatic assay which measures the production of FIP. Compounds ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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