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Found 42 with Last Name = 'reese' and Initial = 'rm'
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50573115(CHEMBL4865238)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50573116(CHEMBL4870870)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263528(CHEMBL4079886)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263509(CHEMBL4103545)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM481808(3-[3-(4- chlorophenyl)cyclobutyl]-5- [(7-methyl-6-...)
Affinity DataIC50:  7.40nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50:  7.40nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50573116(CHEMBL4870870)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263519(CHEMBL4092287)
Affinity DataIC50:  8nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263519(CHEMBL4092287)
Affinity DataIC50:  8.40nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50573115(CHEMBL4865238)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263567(CHEMBL4098855)
Affinity DataIC50:  10nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263547(CHEMBL4077957 | US11236046, Example 41)
Affinity DataIC50:  13nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263536(CHEMBL4086464)
Affinity DataIC50:  13nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM481808(3-[3-(4- chlorophenyl)cyclobutyl]-5- [(7-methyl-6-...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM481772((R)-3-(2-(4-chlorophenyl)- 2-fluoroethyl)-5-((7-me...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM481772((R)-3-(2-(4-chlorophenyl)- 2-fluoroethyl)-5-((7-me...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263537(CHEMBL4077623)
Affinity DataIC50:  33nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50263519(CHEMBL4092287)
Affinity DataIC50:  36nMAssay Description:Inhibition of rat TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50263519(CHEMBL4092287)
Affinity DataIC50:  36nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263527(CHEMBL4087767)
Affinity DataIC50:  64nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263527(CHEMBL4087767)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263553(CHEMBL4103225 | US11236046, Example 193)
Affinity DataIC50:  69nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263535(CHEMBL4085297)
Affinity DataIC50:  96nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263529(CHEMBL4104134)
Affinity DataIC50:  113nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263539(CHEMBL4104646)
Affinity DataIC50:  154nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263526(CHEMBL4062110)
Affinity DataIC50:  179nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263526(CHEMBL4062110)
Affinity DataIC50:  180nMAssay Description:Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263552(CHEMBL4066447)
Affinity DataIC50:  184nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263525(CHEMBL4083847 | US11236046, Example 39)
Affinity DataIC50:  239nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263538(CHEMBL4064602)
Affinity DataIC50:  328nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50263527(CHEMBL4087767)
Affinity DataIC50:  390nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263523(CHEMBL4066996 | US11236046, Example 3)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263521(CHEMBL4080418 | US11236046, Example 201)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50263526(CHEMBL4062110)
Affinity DataIC50:  1.60E+3nMAssay Description:Antagonist activity at rat TRPA1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263522(CHEMBL4088270)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263524(CHEMBL4096004 | US11236046, Example 4)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM452523(1-((3-((3R,5R)-5-(4- chlorophenyl)tetrahydro- fura...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50263520(CHEMBL4096911)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as inhibition of cinnamaldehyde-induced Ca2+ influx preincubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50263519(CHEMBL4092287)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human TRPV1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Pharmaron-Beijing

Curated by ChEMBL
LigandPNGBDBM50263519(CHEMBL4092287)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human TRPM8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed