Found 194 with Last Name = 'duffy' and Initial = 's' TargetProteasome subunit beta type-5(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataKi: 0.130nMAssay Description:Binding affinity to human 20S constitutive proteasome beta 5 subunit assessed as equilibrium constant using fluorogenic peptide Ac-WLA-AMC as substra...More data for this Ligand-Target Pair
Affinity DataKi: 300nMAssay Description:Inhibition of human APN expressed in HEK293 cells preincubated for 20 mins followed by L-leucine-7-amido-4-methylcoumarin addition by fluorescence as...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataKi: 487nMAssay Description:Binding affinity to human 20S constitutive proteasome beta 2 subunit assessed as equilibrium constant using fluorogenic peptide Ac-WLR-AMC as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 0.430nMAssay Description:Inhibition of MMP2 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibition of MMP9 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...More data for this Ligand-Target Pair
3D Structure (crystal)TargetProteasome subunit beta type-9(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human 20S immunoproteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence of PA2...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 57nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-8(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human 20S immunoproteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presence of P...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using ZMAL as substrate me...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 79nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 97nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using Diethoxyfluore...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using Diethoxyfluore...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using Diethoxyfluore...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibition of 5-HT uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of MMP2 (unknown origin) preincubated for 1 hr followed by (QF)-24 substrate addition measured at 1 min time interval for 1 hr by fluoresc...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of human 20S constitutive proteasome beta 5 subunit chymotrypsin-like activity using fluorogenic peptide Ac-WLA-AMC as substrate in presen...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 304nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of human 20S constitutive proteasome beta 1 subunit caspase-like activity using fluorogenic peptide Ac-nLPnLD-AMC as substrate in presence...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 377nMAssay Description:Inhibition of noradrenaline uptake in rat synaptosomal fractionMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 390nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 428nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 440nMAssay Description:Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 540nMAssay Description:Inhibition of human 20S immunoproteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of PA28al...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Heinrich-Heine-Universit£T D£Sseldorf
Curated by ChEMBL
Affinity DataIC50: 552nMAssay Description:Inhibition of recombinant full length human C-terminal His/FLAG tagged HDAC1 expressed in baculovirus infected Sf9 insect cells using ZMAL as substra...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Homo sapiens (Human))
The University Of Melbourne
Curated by ChEMBL
The University Of Melbourne
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of human 20S constitutive proteasome beta 2 subunit trypsin-like activity using fluorogenic peptide Ac-WLR-AMC as substrate in presence of...More data for this Ligand-Target Pair
