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maximum 50k data
Found 198 with Last Name = 'dugdale' and Initial = 's'
TargetCannabinoid receptor 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364234(CHEMBL1952279)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364235(CHEMBL1952280)
Affinity DataKi:  249nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364234(CHEMBL1952279)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364235(CHEMBL1952280)
Affinity DataKi:  4.02E+3nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  1.09E+4nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310923(CHEMBL1077943 | US9120807, 6 | {6-Methylamino-2-[(...)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310932((+/-)-[2-(1-Pyridin-3-yl-ethylamino)-thieno[3,2-d]...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310921(CHEMBL1080068 | {6-Chloro-2-[(pyridin-3-ylmethyl)-...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310909((5-methylthiophen-2-yl)(2-(1-(pyridin-3-yl)ethylam...)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310912((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310934((S)-[2-(1-Pyridin-3-yl-ethylamino)-thieno[3,2-d]py...)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310924(CHEMBL1080421 | US9120807, 8 | {6-Ethylamino-2-[(p...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310908((5-methylthiophen-2-yl)(2-(1-(pyridin-2-yl)ethylam...)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310922(CHEMBL1080241 | US9120807, 9 | {6-Amino-2-[(pyridi...)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310925(CHEMBL1081160 | US9120807, 7 | {6-dimethylamino-2-...)
Affinity DataIC50:  39nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310901((5-methylthiophen-2-yl)(2-(pyridin-2-ylmethylamino...)
Affinity DataIC50:  43nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310912((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  51nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310902((5-methylthiophen-2-yl)(2-(pyridin-3-ylmethylamino...)
Affinity DataIC50:  55nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310921(CHEMBL1080068 | {6-Chloro-2-[(pyridin-3-ylmethyl)-...)
Affinity DataIC50:  62nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310903((5-methylthiophen-2-yl)(2-(pyrimidin-4-ylmethylami...)
Affinity DataIC50:  92nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364235(CHEMBL1952280)
Affinity DataIC50:  94nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310909((5-methylthiophen-2-yl)(2-(1-(pyridin-3-yl)ethylam...)
Affinity DataIC50:  99nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310919(CHEMBL1081873 | pyridin-3-yl(2-(pyridin-3-ylmethyl...)
Affinity DataIC50:  109nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296484((S)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50:  112nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310903((5-methylthiophen-2-yl)(2-(pyrimidin-4-ylmethylami...)
Affinity DataIC50:  116nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310908((5-methylthiophen-2-yl)(2-(1-(pyridin-2-yl)ethylam...)
Affinity DataIC50:  118nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310927(2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimi...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364259(CHEMBL1952091)
Affinity DataIC50:  126nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310897((2-(ethylamino)thieno[3,2-d]pyrimidin-4-yl)(5-meth...)
Affinity DataIC50:  126nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310913((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  148nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310915((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  148nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364258(CHEMBL1952090)
Affinity DataIC50:  161nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310904(CHEMBL1078001 | N-(4-(5-methylthiophene-2-carbonyl...)
Affinity DataIC50:  161nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310914((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  176nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310906((5-methylthiophen-2-yl)(2-(2-(pyridin-3-yl)ethylam...)
Affinity DataIC50:  177nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310901((5-methylthiophen-2-yl)(2-(pyridin-2-ylmethylamino...)
Affinity DataIC50:  186nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310931(CHEMBL1078030 | {2-[(Pyridin-3-ylmethyl)-amino]-th...)
Affinity DataIC50:  189nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310917((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  215nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310896((2-aminothieno[3,2-d]pyrimidin-4-yl)(5-methylthiop...)
Affinity DataIC50:  220nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364261(CHEMBL1952093)
Affinity DataIC50:  237nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364234(CHEMBL1952279)
Affinity DataIC50:  242nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310929(2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimi...)
Affinity DataIC50:  256nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310904(CHEMBL1078001 | N-(4-(5-methylthiophene-2-carbonyl...)
Affinity DataIC50:  287nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310928(2-[(Pyridin-3-ylmethyl)-amino]-thieno[3,2-d]pyrimi...)
Affinity DataIC50:  309nMAssay Description:Antagonist activity at human adeosine A2B receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310905((5-methylthiophen-2-yl)(2-(2-(pyridin-2-yl)ethylam...)
Affinity DataIC50:  351nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364262(CHEMBL1952094)
Affinity DataIC50:  370nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364240(CHEMBL1952072)
Affinity DataIC50:  375nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50364268(CHEMBL1952265)
Affinity DataIC50:  388nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50310913((2-(pyridin-3-ylmethylamino)thieno[3,2-d]pyrimidin...)
Affinity DataIC50:  405nMAssay Description:Antagonist activity at human adeosine A2A receptor expressed in CHOK1 cells assessed as inhibition of calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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