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Found 93 with Last Name = 'sestito' and Initial = 's'
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50341243((3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylam...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405822(US10351548, Compound IB36)
Affinity DataIC50:  19nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50184998(CHEMBL3823242)
Affinity DataIC50:  27nMAssay Description:Inhibition of PDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582136(CHEMBL5085987)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405827(US10351548, Compound DD21)
Affinity DataIC50:  103nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405827(US10351548, Compound DD21)
Affinity DataIC50:  103nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582135(CHEMBL5087446)
Affinity DataIC50:  103nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185001(CHEMBL3824119 | US10351548, Compound IB35)
Affinity DataIC50:  112nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185001(CHEMBL3824119 | US10351548, Compound IB35)
Affinity DataIC50:  112nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582138(CHEMBL5092990)
Affinity DataIC50:  118nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582137(CHEMBL5078188)
Affinity DataIC50:  134nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582136(CHEMBL5085987)
Affinity DataIC50:  148nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582135(CHEMBL5087446)
Affinity DataIC50:  193nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029089(CHEMBL3360821)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029089(CHEMBL3360821)
Affinity DataIC50:  200nMAssay Description:Antagonist activity at human TLR4 expressed in HEK293 cells co-transfected with human MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLymphocyte antigen 96(Homo sapiens (Human))
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50239337(CHEMBL4072822)
Affinity DataIC50:  200nMAssay Description:Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405829(US10351548, Compound DF8)
Affinity DataIC50:  245nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405828(US10351548, Compound DD40)
Affinity DataIC50:  245nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405828(US10351548, Compound DD40)
Affinity DataIC50:  245nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405829(US10351548, Compound DF8)
Affinity DataIC50:  245nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  272nMAssay Description:Inhibition of GSK3beta (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  274nMAssay Description:Inhibition of CHK1 (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499155(CHEMBL3736436)
Affinity DataIC50:  310nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279007(CHEMBL4166349)
Affinity DataIC50:  340nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279006(CHEMBL4174650)
Affinity DataIC50:  356nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50278993(CHEMBL4166749)
Affinity DataIC50:  378nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  416nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  416nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185000(CHEMBL3823844 | US10351548, Compound SA16)
Affinity DataIC50:  416nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279005(CHEMBL4170157)
Affinity DataIC50:  452nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582134(CHEMBL5092987)
Affinity DataIC50:  455nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50582138(CHEMBL5092990)
Affinity DataIC50:  475nMAssay Description:Inhibition of recombinant full length human His-tagged PDK1 expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279013(CHEMBL4176974)
Affinity DataIC50:  507nMAssay Description:Inhibition of BuChE (unknown origin) pre-incubated for 20 mins before S-Butyrylthiocholine iodide substrate addition by Ellman reagent based spectrop...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279008(CHEMBL4173608)
Affinity DataIC50:  511nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185003(CHEMBL3824264 | US10351548, Compound JJ31)
Affinity DataIC50:  512nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50185003(CHEMBL3824264 | US10351548, Compound JJ31)
Affinity DataIC50:  512nMAssay Description:Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029089(CHEMBL3360821)
Affinity DataIC50:  600nMAssay Description:Inhibition of LPS-induced TLR4 activation (unknown origin) expressed in HEK293 Blue cells compound treated for 30 mins prior LPS treatment measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029088(CHEMBL3360820)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at human TLR4 expressed in HEK293 cells co-transfected with human MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029088(CHEMBL3360820)
Affinity DataIC50:  600nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405829(US10351548, Compound DF8)
Affinity DataIC50:  611nMAssay Description:Inhibition of recombinant full length human His-tagged AURA expressed in Baculovirus expression system in presence of ATP measured by Bradford protei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50279012(CHEMBL4162892)
Affinity DataIC50:  650nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM11682(2,3-dihydroxybutanedioic acid; 3-[(1S)-1-(dimethyl...)
Affinity DataIC50:  678nMAssay Description:Inhibition concentration against human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetLymphocyte antigen 96(Homo sapiens (Human))
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50239340(CHEMBL4081306)
Affinity DataIC50:  700nMAssay Description:Binding affinity to CD14/MD2 (unknown origin) expressed in HEK-Blue cells co-expressing TLR4 assessed as inhibition of LPS-induced TLR4 signaling pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Mus musculus)
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029087(CHEMBL3360819)
Affinity DataIC50:  800nMAssay Description:Antagonist activity at mouse TLR4 expressed in HEK293 cells co-transfected with mouse MD-2/CD14 assessed as inhibition of LPS-stimulated receptor sig...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  884nMAssay Description:Inhibition of GSK3alpha (unknown origin) in presence of 10 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  980nMAssay Description:Inhibition of PDK1 (unknown origin) incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50499153(CHEMBL3091673)
Affinity DataIC50:  998nMAssay Description:Inhibition of PDK1 (unknown origin) in presence of 25 uM ATP incubated for 1 hr by Z'Lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToll-like receptor 4(Homo sapiens (Human))
University Of Sevilla

Curated by ChEMBL
LigandPNGBDBM50029087(CHEMBL3360819)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of LPS-induced TLR4 activation (unknown origin) expressed in HEK293 Blue cells compound treated for 30 mins prior LPS treatment measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM405826(US10351548, Compound DD22)
Affinity DataIC50:  1.34E+3nMAssay Description:Factor IX is a key component of the plasma system that forms a fibrin clot at a site of vascular injury. The activity of Factor IXa is measured by mo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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