Found 342 with Last Name = 'de castro' and Initial = 's' 
Affinity DataKi: 200nMAssay Description:Mixed non-competitive inhibition of Leishmania infantum TryR using TS2 as substrate assessed as inhibition constant of two-step induced-fit mechanism...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Mixed non-competitive inhibition of Leishmania infantum TryR using TS2 as substrate assessed as inhibition constant of first equilibrium by plot anal...More data for this Ligand-Target Pair
TargetAdenosine receptor A3(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
National Institute Of Diabetes And Digestive And Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 4.69E+3nMAssay Description:Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 7.30E+3nMAssay Description:Competitive inhibition of HIS-FLAG-tagged recombinant Leishmania infantum TryR expressed in Escherichia coli using TS2 substrate assessed as inhibiti...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of HIV1 reverse transcriptase polymerase p51/p66 after 10 to 20 mins in presence of [3H]-TTP by liquid scintillation counting methodMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant HIV-1 BH10 reverse transcriptase p51/p66 expressed in Escherichia coli preincubated for 10 mins followed by D38/25PGA templ...More data for this Ligand-Target Pair
TargetCruzipain(Trypanosoma cruzi)
Instituto De Tecnologia Em F£Rmacos - Farmanguinhos
Curated by ChEMBL
Instituto De Tecnologia Em F£Rmacos - Farmanguinhos
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of Trypanosoma cruzi cruzainMore data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant Leishmania infantum trypanothione reductase using T[S]2 as substrate preincubated for 5 mins followed by substrate and NADP...More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 2.08E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 3.47E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 3.59E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of HIS-tagged recombinant Trypanosoma congolense TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by sp...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of HIV1 3B reverse transcriptase using polyC/oligo(dG12) as template/primer in presence of [3H]dGTP and calf thymus DNA after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of HIS-tagged recombinant Trypanosoma congolense TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by sp...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of HIS-tagged recombinant Trypanosoma brucei TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectr...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of HIS-tagged recombinant Trypanosoma brucei TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spectr...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant Leishmania infantum trypanothione reductase using T[S]2 as substrate preincubated for 5 mins followed by substrate and NADP...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of recombinant Leishmania infantum trypanothione reductase using T[S]2 as substrate preincubated for 5 mins followed by substrate and NADP...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Instituto De Qu£Mica M£Dica (Iqm, Csic)
Curated by ChEMBL
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase RNase H using RNA-DNA hybrid duplex after 30 mins by FRET-based microplate fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of HIS-tagged recombinant Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli in the presence of NADPH by spect...More data for this Ligand-Target Pair
Affinity DataIC50: 8.78E+3nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
