TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 0.180nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 0.640nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha3beta3gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Displacement of [3H]-flumazenil from human GABAA alpha5beta2gamma2 receptor expressed in HEK293 cell membranes measured after 2 hrs by liquid scintil...More data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of recombinant human PDE4D2 using [3H]cAMP as substrate measured after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of recombinant human ABL using Ulight-TK peptide as substrate measured after 30 mins by LANCE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+4nMAssay Description:Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.28E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human ERG by electrophysiology methodMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair