Affinity DataKi: 0.200nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Eth Zurich (Swiss Federal Institute Of Technology)
Curated by ChEMBL
Eth Zurich (Swiss Federal Institute Of Technology)
Curated by ChEMBL
Affinity DataKi: 0.575nMAssay Description:Binding affinity to human recombinant histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eth Zurich (Swiss Federal Institute Of Technology)
Curated by ChEMBL
Eth Zurich (Swiss Federal Institute Of Technology)
Curated by ChEMBL
Affinity DataKi: 0.654nMAssay Description:Binding affinity to rat cerebral cortex histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]-CP-55940 from human CB2 receptor transfected in CHOK1 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]-CP-55940 from human CB2 receptor transfected in CHOK1 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Eth Zurich (Swiss Federal Institute Of Technology)
Curated by ChEMBL
Eth Zurich (Swiss Federal Institute Of Technology)
Curated by ChEMBL
Affinity DataKi: 1.26nMAssay Description:Binding affinity to rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Displacement of [3H]-CP-55940 from human CB2 receptor transfected in CHOK1 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]CP-55,940 from human CB2 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]CP-55,940 from human CB2 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of (+)-[3H]-pentazocine from sigma 1 receptor in Dunkin guinea pig brain membranes without cerebellumMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Displacement of [3H]-CP-55940 from human CB2 receptor transfected in CHOK1 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.40nMAssay Description:Displacement of [3H]-ABP688 from mGluR5 receptor in Sprague-Dawley rat brain after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.70nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 3.80nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.90nMAssay Description:Binding affinity to human CB2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.01nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.40nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 4.60nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 5.42nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat cerebellum membranes after 45 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 5.70nMAssay Description:Displacement of [3H]-ABP688 from mGluR5 receptor in Sprague-Dawley rat brain after 45 mins by beta countingMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]-(+)pentazocine from sigma-1 receptor in guinea pig brain membranes after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 6.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 6.90nMAssay Description:Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Displacement of [3H]-CP-55940 from human CB2 receptor transfected in CHOK1 cells after 90 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.41nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Displacement of [3H]-ABP688 from mGluR5 receptor in Sprague-Dawley rat brain after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 9.15nMAssay Description:Displacement of [3H]M-MPEP from mGluR5 in Sprague-Dawley rat brain P2 membrane after 45 mins by beta countingMore data for this Ligand-Target Pair
Affinity DataKi: 9.70nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Curated by ChEMBL
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by scintillatio...More data for this Ligand-Target Pair
Affinity DataKi: 10.9nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain cortex membranes incubated for 120 mins by scintillation counting metho...More data for this Ligand-Target Pair
Affinity DataKi: 11.4nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair
Affinity DataKi: 11.7nMAssay Description:The affinity of the compounds of the invention for cannabinoid CB1 receptors was determined using recommended amounts of membrane preparations (Perki...More data for this Ligand-Target Pair