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Found 291 with Last Name = 'morris' and Initial = 'sw'
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  500nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  5.30E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  8.80E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 minsMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296352(1-(8-(3-(4-methylpiperazin-1-yl)cyclobutyl)-2-phen...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296353(1-(8-(3-(aziridin-1-yl)cyclobutyl)-2-phenylquinoli...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296355(CHEMBL553443 | N-(2-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human GST-tagged IGF1R by trans-phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  51nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM4293((2E)-3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphen...)
Affinity DataIC50:  61nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  68nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  73nMAssay Description:Inhibition of insulin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296355(CHEMBL553443 | N-(2-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  80nMAssay Description:Inhibition of IGF1R in human MCF7 cells by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  86nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296356(CHEMBL541762 | N-(5-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  90nMAssay Description:Inhibition of GST-tagged human IGF1R expressed in baculovirus-infected Sf21 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50:  94nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  140nMAssay Description:Inhibition of insulin receptor-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Mus musculus)
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  150nMAssay Description:Inhibition of IGF1R-mediated proliferation of mouse NIH/3T3 cells after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of IGF1R by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296357(4,4'-(benzo[d][1,3]dioxol-5-ylazanediyl)bis(methyl...)
Affinity DataIC50:  170nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296356(CHEMBL541762 | N-(5-(5-(3,5-difluorophenylsulfonyl...)
Affinity DataIC50:  300nMAssay Description:Inhibition of IGF1R in IGF1-stimulated human MCF7 cells by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296354(CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...)
Affinity DataIC50:  340nMAssay Description:Inhibition of IGF1R in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM27879(4-{[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-...)
Affinity DataIC50:  341nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  600nMAssay Description:Inhibition of 6xHis-tagged NPM-ALK using biotinylated-poly(GT) peptide as substrate after 60 minsMore data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50:  650nMAssay Description:Inhibition of recombinant IRK using biotinylated-poly(GT) peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296351((R)-4-(2-(2-chlorophenyl)-2-hydroxyethylamino)-3-(...)
Affinity DataIC50:  830nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50230005(1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4...)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of IGF1R in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296350((S)-3-(4-(2-(4-(2-(2-chlorophenyl)-2-hydroxyethyla...)
Affinity DataIC50: >1.50E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of insulin receptor by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181674(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50348945(CHEMBL1807757)
Affinity DataIC50:  3.03E+3nMAssay Description:Inhibition of 6xHis-tagged NPM-ALK using biotinylated-poly(GT) peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296354(CHEMBL549369 | N-(5-(3,5-difluorophenylsulfonyl)-4...)
Affinity DataIC50:  3.05E+3nMAssay Description:Inhibition for IGF1R-induced S6 ribosomal protein phosphorylation in growth factor-stimulated NHDFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of human recombinant IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50201127(3-(5-(1H-imidazol-1-yl)-7-methyl-1H-benzo[d]imidaz...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.60E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181671(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181679(5-(2-methyl-benzothiazol-5-yl)-2-oxo-1,2-dihydro-p...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  3.80E+3nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Chembridge Research Laboratories And Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50348945(CHEMBL1807757)
Affinity DataIC50:  4.01E+3nMAssay Description:Inhibition of recombinant MET using biotinylated-poly(GT) peptide as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50294542(1-Methoxy-3-methyl-10-(4-methyl-piperazin-1-yl)-5-...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of recombinant IGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296347(5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cycl...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
University Of South Florida

Curated by ChEMBL
LigandPNGBDBM50296348(7-(3-(azetidin-1-yl)cyclobutyl)-5-(3-(benzyloxy)ph...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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