Affinity DataKi: 65nM ΔG°: -41.0kJ/mole IC50: 92nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataKi: >300nM ΔG°: >-37.2kJ/mole IC50: >3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataKi: 560nM ΔG°: -35.7kJ/mole IC50: 770nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataKi: >800nM ΔG°: >-34.8kJ/mole IC50: >3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataKi: >1.30E+3nM ΔG°: >-33.6kJ/mole IC50: >3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Target4-aminobutyrate aminotransferase, mitochondrial(Rattus norvegicus)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 3.10E+4nMAssay Description:Inactivation of GABA-AT in rat brain homogenateMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1 [F484A,T518L]/3A(Rattus norvegicus (Rat))
University of Copenhagen
University of Copenhagen
Affinity DataKi: 3.50E+4nM ΔG°: -25.4kJ/mole IC50: 9.70E+4nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1 [F484A,T518L]/3B(Rattus norvegicus (Rat))
University of Copenhagen
University of Copenhagen
Affinity DataKi: >1.50E+5nM ΔG°: >-21.8kJ/mole IC50: >3.00E+5nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataKi: >1.80E+5nM ΔG°: >-21.4kJ/mole IC50: >3.00E+5nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Target4-aminobutyrate aminotransferase, mitochondrial(Homo sapiens (Human))
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 3.20E+6nMAssay Description:Inactivation of GABA-ATMore data for this Ligand-Target Pair
Target4-aminobutyrate aminotransferase, mitochondrial(Rattus norvegicus)
Northwestern University
Curated by ChEMBL
Northwestern University
Curated by ChEMBL
Affinity DataKi: 1.00E+7nMAssay Description:Inactivation of GABA-AT in rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at mGlu2 receptor expressed in CHO cells assessed as increase of cAMP levelMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >50nMAssay Description:Agonist activity at mGlu2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP levelMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP levelMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP levelMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu4 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP levelMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR2 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Binding affinity at mGluR4 expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production after 10 minsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >10nMAssay Description:Agonist activity at mGlu2 receptor expressed in CHO cells assessed as inhibition of forskolin-induced increase of cAMP levelMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The University Of Adelaide
Curated by ChEMBL
The University Of Adelaide
Curated by ChEMBL
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at mGlu1 receptor expressed in CHO cells assessed as myo-[2-3H]Inositol turnover by scintillation countingMore data for this Ligand-Target Pair