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Found 616 with Last Name = 'pendharkar' and Initial = 'v'
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502427(CHEMBL4542517)
Affinity DataKi:  440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502433(CHEMBL4575866)
Affinity DataKi:  3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502434(CHEMBL4551647)
Affinity DataKi:  3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50133870(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of porcupine (unknown origin)More data for this Ligand-Target Pair
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50257135(CHEMBL4080208)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50233628(CHEMBL4088716)
Affinity DataIC50:  1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50257160(CHEMBL4096728)
Affinity DataIC50:  1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50257143(CHEMBL4080021)
Affinity DataIC50:  1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50233629(CHEMBL4080842)
Affinity DataIC50:  1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470392(CHEMBL4283208)
Affinity DataIC50:  2nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50233636(CHEMBL4070649)
Affinity DataIC50:  2nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470399(CHEMBL4286573)
Affinity DataIC50:  2nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C iota type(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455611(CHEMBL4212424)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C iota type(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455569(CHEMBL4202753)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50133866(CHEMBL3633802)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of porcupine (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470397(CHEMBL4294536)
Affinity DataIC50:  3nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470406(CHEMBL4295081)
Affinity DataIC50:  3nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470392(CHEMBL4283208)
Affinity DataIC50:  3nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C iota type(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455593(CHEMBL4208685)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470407(CHEMBL4286625)
Affinity DataIC50:  4nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470403(CHEMBL4294467)
Affinity DataIC50:  4nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470393(CHEMBL4291061)
Affinity DataIC50:  4nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50233635(CHEMBL4099279)
Affinity DataIC50:  4nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470400(CHEMBL4289998)
Affinity DataIC50:  4nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50233630(CHEMBL4084739)
Affinity DataIC50:  5nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470401(CHEMBL4290062)
Affinity DataIC50:  5nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C iota type(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455592(CHEMBL4206065)
Affinity DataIC50:  5nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470396(CHEMBL4293447)
Affinity DataIC50:  6nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470394(CHEMBL4281775)
Affinity DataIC50:  6nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470403(CHEMBL4294467)
Affinity DataIC50:  6nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50006565(CHEMBL3235085)
Affinity DataIC50:  6nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50257141(CHEMBL4069295)
Affinity DataIC50:  6nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C iota type(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM50455602(CHEMBL4216507)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of full-length N-terminal GST-fused human PKC-iota expressed in baculovirus expression system using (5FAM) RFARKGSLRQKNV as substrate afte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170222(CHEMBL3805771)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470404(CHEMBL4279382)
Affinity DataIC50:  7nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50233633(CHEMBL4089128)
Affinity DataIC50:  7nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470394(CHEMBL4281775)
Affinity DataIC50:  8nMAssay Description:Inhibition of Escherichia coli ParEMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170223(CHEMBL3805330)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470395(CHEMBL4279313)
Affinity DataIC50:  8nMAssay Description:Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50257139(CHEMBL4104447)
Affinity DataIC50:  8nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470402(CHEMBL4278317)
Affinity DataIC50:  8nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170218(CHEMBL3804952)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470400(CHEMBL4289998)
Affinity DataIC50:  9nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL
LigandPNGBDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)
Affinity DataIC50:  9nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 4 subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470395(CHEMBL4279313)
Affinity DataIC50:  9nMAssay Description:Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50470405(CHEMBL4289650)
Affinity DataIC50:  9nMAssay Description:Inhibition of Escherichia coli GyrB (1 to 220 residues) expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50257144(CHEMBL4066589)
Affinity DataIC50:  9nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50:  10nMAssay Description:Inhibition of BCR fused full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL
LigandPNGBDBM50170221(CHEMBL3806189)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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