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Found 1132 with Last Name = 'taylor' and Initial = 'v'
TargetCytochrome P450 1A2(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593319(CHEMBL5188333)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589401(CHEMBL5169945)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589421(CHEMBL5187995)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582250(CHEMBL5075301)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system by Z'-lyte assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589432(CHEMBL5178313)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582258(CHEMBL5094640)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589397(CHEMBL5185144)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589400(CHEMBL5175590)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589414(CHEMBL5192205)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589418(CHEMBL5183959)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589424(CHEMBL5187663)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582248(CHEMBL5076447)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582254(CHEMBL5088588)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589417(CHEMBL5198583)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589420(CHEMBL5181320)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589423(CHEMBL5175829)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589431(CHEMBL5200765)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589433(CHEMBL5193503)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582257(CHEMBL5079737)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582262(CHEMBL5087788)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589425(CHEMBL5208062)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589426(CHEMBL5178272)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589428(CHEMBL5207689)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582251(CHEMBL5079990)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582265(CHEMBL5091192)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589399(CHEMBL5201935)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589419(CHEMBL5184745)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582249(CHEMBL5090193)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589406(CHEMBL5188095)
Affinity DataIC50:  7nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM594971(US11584758, Compound I-57)
Affinity DataIC50:  7.90nMAssay Description:In this example, compounds of the disclosure were evaluated using a biochemical assay using the ADP-Glo™ technology. ADP-Glo™ (Promega, Madison, Wis....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human primary T-cells assessed as reduction of IFN-alpha induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582264(CHEMBL5093825)
Affinity DataIC50:  8nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582248(CHEMBL5076447)
Affinity DataIC50:  8nMAssay Description:Inhibition of TAK1 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589416(CHEMBL5177543)
Affinity DataIC50:  8nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM604982(US11667643, Compound I-12 | US11667643, Compound I...)
Affinity DataIC50:  8.10nMAssay Description:ADP-Glo (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM578711(US11479543, Compound I-22)
Affinity DataIC50:  8.30nMAssay Description:ADP-Glo (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM594974(US11584758, Compound I-60)
Affinity DataIC50:  8.5nMAssay Description:In this example, compounds of the disclosure were evaluated using a biochemical assay using the ADP-Glo™ technology. ADP-Glo™ (Promega, Madison, Wis....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593315(CHEMBL5209379)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593316(CHEMBL5170161)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582260(CHEMBL5077968)
Affinity DataIC50:  9nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589429(CHEMBL5173098)
Affinity DataIC50:  9nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM604997(US11667643, Compound I-29)
Affinity DataIC50:  9.80nMAssay Description:ADP-Glo (Promega, Madison, Wis., USA) reagents were thawed at ambient temperature. Kinase Detection Reagent was prepared by mixing kinase detection b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM594934(US11584758, Compound I-20)
Affinity DataIC50:  9.90nMAssay Description:In this example, compounds of the disclosure were evaluated using a biochemical assay using the ADP-Glo™ technology. ADP-Glo™ (Promega, Madison, Wis....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582266(CHEMBL5094876)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589396(CHEMBL5170107)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589405(CHEMBL5170085)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582252(CHEMBL5085979)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50582253(CHEMBL5071152)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin) in presence of MBP as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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