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Found 48 with Last Name = 'xu-liu' and Initial = 'na'
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))TBA
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of BTK C481S mutant (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM291388((R)-1-(3-((6-amino-5-(4-phenoxyphenyl)pyrimidin-4-...)
Affinity DataIC50:  0.5nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.5nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50:  0.700nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM389631(6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)ni...)
Affinity DataIC50:  1.60nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50588021(CHEMBL4303247)
Affinity DataIC50:  1.90nMAssay Description:Reversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50:  2.20nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of BRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610908(CHEMBL5271514)
Affinity DataIC50:  2.5nMAssay Description:Competitive inhibition of recombinant human BTK incubated for 10 mins in the presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataIC50:  3nMAssay Description:Irreversible inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM50610910(CHEMBL5280844)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601461(CHEMBL5203118)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of BTK (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610912(CHEMBL5288995)
Affinity DataIC50: <5nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))TBA
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))TBA
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610913(CHEMBL5289623)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601462(CHEMBL5200275)
Affinity DataIC50:  7nMAssay Description:Inhibition of BTK (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601451(CHEMBL5172511)
Affinity DataIC50:  18nMAssay Description:Inhibition of BTK (unknown origin) incubated for 60 mins in the presence of ATP by ADP-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601456(CHEMBL5202915)
Affinity DataIC50:  27nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50601461(CHEMBL5203118)
Affinity DataIC50:  29nMAssay Description:Inhibition of wildtype EGFR (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601457(CHEMBL5206407)
Affinity DataIC50:  36nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610914(CHEMBL5272842)
Affinity DataIC50:  39nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50610918(CHEMBL5270006)
Affinity DataIC50:  40nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601452(CHEMBL5185980)
Affinity DataIC50:  42nMAssay Description:Inhibition of BTK (unknown origin) incubated for 60 mins in the presence of ATP by ADP-Glo reagent based luminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50601462(CHEMBL5200275)
Affinity DataIC50:  47nMAssay Description:Inhibition of wildtype EGFR (unknown origin) by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610915(CHEMBL5282968)
Affinity DataIC50:  50nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601454(CHEMBL5183488)
Affinity DataIC50:  75nMAssay Description:Inhibition of BTK (unknown origin) incubated for 40 mins in the presence of ATP by scintillation based radiometric protein kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  78nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM50610911(CHEMBL5172091)
Affinity DataIC50:  80nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50610919(CHEMBL5289797)
Affinity DataIC50:  90nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50610916(CHEMBL5274913)
Affinity DataIC50:  110nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  200nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50:  580nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50610917(CHEMBL5285367)
Affinity DataIC50:  600nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610918(CHEMBL5270006)
Affinity DataIC50:  660nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610919(CHEMBL5289797)
Affinity DataIC50:  900nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))TBA
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))TBA
LigandPNGBDBM50610909(CHEMBL5285357)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610916(CHEMBL5274913)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610917(CHEMBL5285367)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of BTK (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50610913(CHEMBL5289623)
Affinity DataIC50:  4.31E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))TBA
LigandPNGBDBM50161162(AVL-292 | CC-292 | Spebrutinib | US10596172, Compo...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50610913(CHEMBL5289623)
Affinity DataIC50:  5.18E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50601458(CHEMBL5197174)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of ABL1 (unknown origin) using GGEAIYAAPFKK as substrate in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed