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Found 167 with Last Name = 'akhtar' and Initial = 'mj'
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591808(CHEMBL5207397)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to mouse GAT-1 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591807(CHEMBL5178760)
Affinity DataKi:  8.90nMAssay Description:Binding affinity to mouse GAT-1 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591806(CHEMBL5205864)
Affinity DataKi:  14nMAssay Description:Inhibition of [3H]-GABA uptake at GAT-1 in rat forebrain synaptosomes assessed as inhibition constant preincubated for 8 mins followed by [3H]-GABA a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataKi:  37nMAssay Description:Binding affinity to mouse GAT-1 expressed in human HEK293 cells assessed as inhibition constant in presence of NO711 marker by competitive binding as...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591809(CHEMBL5203365)
Affinity DataKi:  79nMAssay Description:Binding affinity to mouse GAT-1 expressed in human HEK293 cells assessed as inhibition constant in presence of NO711 marker by competitive binding as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50445253(CHEMBL1232500)
Affinity DataKi:  180nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
LigandPNGBDBM50041419(1,2,5,8-tetrahydroxy-9,10-anthracenedione | 1,2,5,...)
Affinity DataKi:  5.85E+3nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM50228403((R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-met...)
Affinity DataIC50:  0.320nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222244(6-Iodo-N3-(3-nitrobenzylidene)-2-phenyl-N4-(thiazo...)
Affinity DataIC50:  0.760nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222254(6-Iodo-N4-(4-methylthiazol-2-yl)-N3-(3-nitrobenzyl...)
Affinity DataIC50:  1.22nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222239(N3-(3-Nitrobenzylidene)-2-phenyl-N4-(thiazol-2-yl)...)
Affinity DataIC50:  1.33nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222245(6-Iodo-N3-(4-methoxybenzylidene)-2-phenyl-N4-(thia...)
Affinity DataIC50:  1.62nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222255(6-Iodo-N3-(4-methoxybenzylidene)-N4-(4-methylthiaz...)
Affinity DataIC50:  1.82nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222249(N4-(4-Methylthiazol-2-yl)-N3-(3-nitrobenzylidene)-...)
Affinity DataIC50:  2.19nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222250(N3-(4-methoxybenzylidene)-N4-(4-methylthiazol-2-yl...)
Affinity DataIC50:  2.42nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222240(N3-(4-Methoxybenzylidene)-2-phenyl-N4-(thiazol-2-y...)
Affinity DataIC50:  2.82nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222247(6-Iodo-N3-(2-methoxybenzylidene)-2-phenyl-N4-(thia...)
Affinity DataIC50:  3.48nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222257(6-Iodo-N3-(2-methoxybenzylidene)-N4-(4-methylthiaz...)
Affinity DataIC50:  3.98nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222252(N3-(2-methoxybenzylidene)-N4-(4-methylthiazol-2-yl...)
Affinity DataIC50:  4.21nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222242(N3-(2-Methoxybenzylidene)-2-phenyl-N4-(thiazol-2-y...)
Affinity DataIC50:  6.51nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222256(N3-(4-(Dimethylamino)-benzylidene)-6-iodo-N4-(4-me...)
Affinity DataIC50:  6.53nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222251(N3-(4-(Dimethylamino)-benzylidene)-N4-(4-methylthi...)
Affinity DataIC50:  6.72nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222253(N3-Benzylidene-6-iodo-N4-(4-methylthiazol-2-yl)-2-...)
Affinity DataIC50:  7.24nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222246(N3-{4-(Dimethylamino)-benzylidene}-6-iodo-2-phenyl...)
Affinity DataIC50:  7.83nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50466848(CHEMBL4283751)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222248(N3-Benzylidene-N4-(4-methylthiazol-2-yl)-2-phenylq...)
Affinity DataIC50:  8.17nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222241(N3-(4-(Dimethylamino)-benzylidene)-2-phenyl-N4-(th...)
Affinity DataIC50:  8.64nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hamdard University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222243(N3-Benzylidene-6-iodo-2-phenyl-N4-(thiazol-2-yl)-q...)
Affinity DataIC50:  12.3nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Jamia Hamdard (Hamdard University)

LigandPNGBDBM222238(N3-Benzylidene-2-phenyl-N4-(thiazol-2-yl)-quinazol...)
Affinity DataIC50:  13.7nMAssay Description:The synthetic title compounds 7 (a-j) and 8 (a-j) were screened for in vitro DPP-4 inhibition using DPP-4 activity assay kit (Krishgen BioSystems). D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))TBA
LigandPNGBDBM50613787(CHEMBL5283881)
Affinity DataIC50:  17nMAssay Description:Inhibition of gamma-secretase (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  17nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50081174(CHEMBL3421968)
Affinity DataIC50:  17nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50162287((Rebeccamycin)1,11-dichloro-12-(3,4-dihydroxy-6-hy...)
Affinity DataIC50:  19nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hamdard University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  24nMAssay Description:Inhibition of HRG stimulated erbB2 phosphorylation in human MCF-7 cells preincubated for 90 mins followed by HRG addition for 5 mins by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  33nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591808(CHEMBL5207397)
Affinity DataIC50:  37nMAssay Description:Inhibition of mouse GAT-1 assessed as inhibition of GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50347750(CHEMBL1802358)
Affinity DataIC50:  40nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50613787(CHEMBL5283881)
Affinity DataIC50:  48nMAssay Description:Inhibition of amyloid beta 40 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613785(CHEMBL5288413)
Affinity DataIC50:  50nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50591807(CHEMBL5178760)
Affinity DataIC50:  52nMAssay Description:Inhibition of mouse GAT-1 assessed as inhibition of GABA uptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50372905(CHEMBL270636)
Affinity DataIC50:  60nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))TBA
LigandPNGBDBM50613787(CHEMBL5283881)
Affinity DataIC50:  67nMAssay Description:Inhibition of amyloid beta 42 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613778(CHEMBL513265)
Affinity DataIC50:  80nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50232320(CHEMBL4103370)
Affinity DataIC50:  81nMAssay Description:Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50232320(CHEMBL4103370)
Affinity DataIC50:  81nMAssay Description:Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50232327(CHEMBL4084249)
Affinity DataIC50:  98nMAssay Description:Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hamdard University

Curated by ChEMBL
LigandPNGBDBM50232327(CHEMBL4084249)
Affinity DataIC50:  98nMAssay Description:Inhibition of EGF induced EGFR phosphorylation in human KB cells preincubated for 90 mins followed by EGF addition for 5 mins by sandwich ELISA metho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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