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Found 55 with Last Name = 'akima' and Initial = 'm'
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043326(CHEMBL438733 | c(Cys-Ser-Cys)-Ser-Ser-Leu-Met-Asp-...)
Affinity DataIC50:  0.0930nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.120nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.150nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043322(CHEMBL427748 | c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp...)
Affinity DataIC50:  0.170nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368776(CHEMBL1790962)
Affinity DataIC50:  0.170nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368773(CHEMBL1790959)
Affinity DataIC50:  0.180nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368774(CHEMBL1790963)
Affinity DataIC50:  0.190nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368775(CHEMBL1790960)
Affinity DataIC50:  0.200nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368772(CHEMBL2373291)
Affinity DataIC50:  0.25nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368774(CHEMBL1790963)
Affinity DataIC50:  0.330nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368776(CHEMBL1790962)
Affinity DataIC50:  0.420nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368777(CHEMBL2373292)
Affinity DataIC50:  0.420nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Bos taurus)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043324(CHEMBL411171 | c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp...)
Affinity DataIC50:  0.450nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in bovine cerebrum membrane for Endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368772(CHEMBL2373291)
Affinity DataIC50:  0.700nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50368777(CHEMBL2373292)
Affinity DataIC50:  0.700nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043322(CHEMBL427748 | c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp...)
Affinity DataIC50:  0.75nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043326(CHEMBL438733 | c(Cys-Ser-Cys)-Ser-Ser-Leu-Met-Asp-...)
Affinity DataIC50:  5.90nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Takeda Chemical Industries

Curated by ChEMBL
LigandPNGBDBM50043324(CHEMBL411171 | c(Cys-Ser-c(Cys-Ser-Ser-Leu-Met-Asp...)
Affinity DataIC50:  8.60nMAssay Description:Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067631(3-(3-{[2-(Benzo[1,3]dioxol-5-yloxy)-ethyl]-methyl-...)
Affinity DataIC50:  62nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067622(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{[2-(3...)
Affinity DataIC50:  93nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067624(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(3,4-...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067630(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{[2-(3...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  200nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  200nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067629(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-[3-(6,7-d...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067638(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-2-(3,5-di-t...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067632(3-{3-[4-(Benzothiazol-2-yl-methyl-amino)-piperidin...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067637(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{[2-(4...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067626(3-[3-(Benzo[1,3]dioxol-5-ylmethyl-methyl-amino)-pr...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067620(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{methy...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043282(2-Methyl-4-thiazol-5-yl-2H-phthalazin-1-one | CHEM...)
Affinity DataIC50:  300nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  300nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  300nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067639(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(2-hy...)
Affinity DataIC50:  420nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067636(3-(3-{[3-(Benzo[1,3]dioxol-5-yloxy)-2-hydroxy-prop...)
Affinity DataIC50:  430nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043282(2-Methyl-4-thiazol-5-yl-2H-phthalazin-1-one | CHEM...)
Affinity DataIC50:  500nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067621(3-[3-(Benzyl-methyl-amino)-propyl]-2-(3,5-di-tert-...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067625(Benzothiazol-2-yl-{1-[4-(4-fluoro-phenoxy)-butyl]-...)
Affinity DataIC50:  760nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067635(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(2-et...)
Affinity DataIC50:  840nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50017896((E)-3-(4-Imidazol-1-ylmethyl-phenyl)-acrylic acid ...)
Affinity DataIC50:  900nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067623(3-[3-(Cyclopropylmethyl-methyl-amino)-propyl]-2-(3...)
Affinity DataIC50:  1.20E+3nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043283(2-Ethyl-4-pyridin-3-yl-2H-phthalazin-1-one | CHEMB...)
Affinity DataIC50:  1.30E+3nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat plateletMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067633(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-dimeth...)
Affinity DataIC50:  1.50E+3nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043283(2-Ethyl-4-pyridin-3-yl-2H-phthalazin-1-one | CHEMB...)
Affinity DataIC50:  1.60E+3nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043283(2-Ethyl-4-pyridin-3-yl-2H-phthalazin-1-one | CHEMB...)
Affinity DataIC50:  1.60E+3nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067640(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(2-di...)
Affinity DataIC50:  1.70E+3nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Rattus norvegicus)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043283(2-Ethyl-4-pyridin-3-yl-2H-phthalazin-1-one | CHEMB...)
Affinity DataIC50:  1.70E+3nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in rat whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50043283(2-Ethyl-4-pyridin-3-yl-2H-phthalazin-1-one | CHEMB...)
Affinity DataIC50:  2.30E+3nMAssay Description:Tested in vitro against TXA2 synthetase inhibitory activity in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50067634(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-methyl...)
Affinity DataIC50:  2.40E+3nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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