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Found 411 with Last Name = 'antczak' and Initial = 'm'
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266122(CHEMBL4070789)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escherichia coli using PGE2 as substrate after 15 mins in presence of NA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266252(CHEMBL4061483)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to 15-PGDH (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266252(CHEMBL4061483)
Affinity DataKi:  0.100nMAssay Description:Inhibition of 15-PGDH (unknown origin) using PGE2 as substrate preincubated for 12 hrs followed by dialysis for 12 hrs and subsequent addition of NAD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650862(US20240043440, Example 58B)
Affinity DataIC50:  0.130nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650874(US20240043440, Example 64A)
Affinity DataIC50:  0.360nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650800(US20240043440, Example 16 | US20240043440, Example...)
Affinity DataIC50:  0.400nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (5 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650868(US20240043440, Example 61A)
Affinity DataIC50:  0.440nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650855(US20240043440, Example 54A)
Affinity DataIC50:  0.450nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650883(US20240043440, Example 68A)
Affinity DataIC50:  0.480nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650865(US20240043440, Example 60A)
Affinity DataIC50:  0.5nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650892(US20240043440, Example 74A)
Affinity DataIC50:  0.520nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650881(US20240043440, Example 67A)
Affinity DataIC50:  0.520nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650861(US20240043440, Example 58A)
Affinity DataIC50:  0.550nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650908(US20240043440, Example 86A)
Affinity DataIC50:  0.560nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650871(US20240043440, Example 62A)
Affinity DataIC50:  0.560nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650847(US20240043440, Example 50A)
Affinity DataIC50:  0.570nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650834(US20240043440, Example 43A)
Affinity DataIC50:  0.580nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650832(US20240043440, Example 42B)
Affinity DataIC50:  0.590nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650877(US20240043440, Example 65A)
Affinity DataIC50:  0.590nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650841(US20240043440, Example 47A)
Affinity DataIC50:  0.650nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650838(US20240043440, Example 46A)
Affinity DataIC50:  0.700nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650826(US20240043440, Example 39A)
Affinity DataIC50:  0.720nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650843(US20240043440, Example 48A)
Affinity DataIC50:  0.720nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650829(US20240043440, Example 41A)
Affinity DataIC50:  0.730nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650852(US20240043440, Example 52A)
Affinity DataIC50:  0.75nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM347359(US10301320, ID SW033291 | US10869871, ID # SW03329...)
Affinity DataIC50:  0.760nMAssay Description:In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650796(US20240043440, Example 12 | US20240043440, Example...)
Affinity DataIC50:  0.760nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (5 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650901(US20240043440, Example 81)
Affinity DataIC50:  0.760nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650823(US20240043440, Example 38A)
Affinity DataIC50:  0.760nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650911(US20240043440, Example 89A)
Affinity DataIC50:  0.770nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650854(US20240043440, Example 54)
Affinity DataIC50:  0.820nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650886(US20240043440, Example 70)
Affinity DataIC50:  0.880nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650863(US20240043440, Example 59)
Affinity DataIC50:  0.910nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650888(US20240043440, Example 72)
Affinity DataIC50:  0.930nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM347365(US10301320, ID SW206992 | US10869871, ID # SW20699...)
Affinity DataIC50:  0.970nMAssay Description:In vivo assays for 15-PGDH expression or 15-PGDH activity, e.g., ligands, agonists, antagonists, and their homologs and mimetics. The term modulator ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM347364(US10301320, ID SW206980 | US10869871, ID # SW20698...)
Affinity DataIC50:  0.970nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH in an in vitro assay. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM347364(US10301320, ID SW206980 | US10869871, ID # SW20698...)
Affinity DataIC50:  0.970nMAssay Description:This Example provides data on a group of structural analogues of SW033291. Data provided includes level of induction of a 15-PGDH-luciferase fusion g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650887(US20240043440, Example 71)
Affinity DataIC50:  0.980nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650889(US20240043440, Example 73)
Affinity DataIC50:  1nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650849(US20240043440, Example 51)
Affinity DataIC50:  1nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650902(US20240043440, Example 82)
Affinity DataIC50:  1nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650899(US20240043440, Example 79-A)
Affinity DataIC50:  1nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650857(US20240043440, Example 55)
Affinity DataIC50:  1nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266191(CHEMBL4072253)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escherichia coli using PGE2 as substrate after 15 mins in presence of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM50266223(CHEMBL4060121)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged 15-PGDH expressed in Escherichia coli using PGE2 as substrate after 15 mins in presence of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650897(US20240043440, Example 78-A)
Affinity DataIC50:  1nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650859(US20240043440, Example 57)
Affinity DataIC50:  1.10nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650867(US20240043440, Example 61)
Affinity DataIC50:  1.10nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650906(US20240043440, Example 86)
Affinity DataIC50:  1.10nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
Target15-hydroxyprostaglandin dehydrogenase [NAD(+)](Homo sapiens (Human))
Ut Southwestern Medical Center

Curated by ChEMBL
LigandPNGBDBM650876(US20240043440, Example 65)
Affinity DataIC50:  1.10nMAssay Description:Each compound for inhibiting enzymatic activity of recombinant 15-PGDH (1 nM) in an in vitro assay.More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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