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Found 65 with Last Name = 'balasubramanian' and Initial = 'n'
TargetHydroxymethylglutaryl-CoA synthase, cytoplasmic(Rattus norvegicus)
Bristol Myers

Curated by ChEMBL
LigandPNGBDBM50452635(CHEMBL2367463)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of rat liver microsomal HMG-CoA reductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014354(6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetraz...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductase using [2-14C]-acetate incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM34168(LOVASTATIN | MLS000069585 | SMR000058779 | US91151...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014356(CHEMBL320666 | Sodium; 9,9-bis-(4-fluoro-2-methyl-...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM34168(LOVASTATIN | MLS000069585 | SMR000058779 | US91151...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductase using [2-14C]-acetate incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxymethylglutaryl-CoA synthase, cytoplasmic(Rattus norvegicus)
Bristol Myers

Curated by ChEMBL
LigandPNGBDBM50014354(6-[4,4-Bis-(4-fluoro-phenyl)-3-(1-methyl-1H-tetraz...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibition of rat liver microsomal HMG-CoA reductase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50011210(CHEMBL342422 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Affinity DataIC50:  43nMAssay Description:Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014345(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Affinity DataIC50:  43nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014358(CHEMBL103192 | Sodium; 9-(4-fluoro-phenyl)-3,5-dih...)
Affinity DataIC50:  44nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014355(CHEMBL103585 | Sodium; 7-(4'-fluoro-3,5,3'-trimeth...)
Affinity DataIC50:  52nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductase using [2-14C]-acetate incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014365(CHEMBL103547 | Sodium; 9,9-bis-(4-fluoro-3-methyl-...)
Affinity DataIC50:  160nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014361(CHEMBL318754 | Sodium; 3,5-dihydroxy-8-(1-methyl-1...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014364(CHEMBL318102 | Sodium; 8-[bis-(4-fluoro-phenyl)-me...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014363(CHEMBL419542 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Affinity DataIC50:  330nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014349(CHEMBL328846 | Sodium; 9,9-bis-(2-fluoro-4-methyl-...)
Affinity DataIC50:  580nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014362(CHEMBL103661 | Sodium; 8-(1-ethyl-1H-tetrazol-5-yl...)
Affinity DataIC50:  1.10E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014346(CHEMBL441642 | Sodium; 3,5-dihydroxy-8-(1-methyl-1...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014350(CHEMBL323075 | Sodium; 3,5-dihydroxy-9,9-bis-(4-me...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014348(CHEMBL100188 | Sodium; 9,9-bis-(2,4-dimethyl-pheny...)
Affinity DataIC50:  1.60E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014351(CHEMBL323373 | Sodium; 8-(2-tert-butyl-2H-tetrazol...)
Affinity DataIC50:  3.70E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductase using [2-14C]-acetate incorporationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014351(CHEMBL323373 | Sodium; 8-(2-tert-butyl-2H-tetrazol...)
Affinity DataIC50:  3.70E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280061(CHEMBL8633 | Sodium; (E)-8-(3,6-difluoro-fluoren-9...)
Affinity DataIC50: >4.10E+3nMAssay Description:Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280060(CHEMBL8746 | Sodium; (E)-7-[5-(4-fluoro-phenyl)-1,...)
Affinity DataIC50:  4.60E+3nMAssay Description:Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50421879(CHEMBL2304072)
Affinity DataIC50:  5.70E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014357(CHEMBL318256 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Affinity DataIC50:  7.90E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014360(CHEMBL322399 | Sodium; 8-cyano-9,9-bis-(4-fluoro-p...)
Affinity DataIC50:  8.00E+3nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014353(CHEMBL319739 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Affinity DataIC50:  1.40E+4nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014352(CHEMBL102468 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Affinity DataIC50:  3.00E+4nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014367(CHEMBL103792 | Sodium; 10,10-bis-(4-fluoro-phenyl)...)
Affinity DataIC50:  1.30E+5nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014366(CHEMBL102484 | Sodium; 8-(2-ethyl-2H-tetrazol-5-yl...)
Affinity DataIC50:  2.00E+5nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280059(CHEMBL8800 | Sodium; (6E,8Z)-9-(4-fluoro-phenyl)-3...)
Affinity DataIC50:  2.10E+5nMAssay Description:Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280062(CHEMBL8886 | Sodium; (6E,8E)-9-(4-fluoro-phenyl)-3...)
Affinity DataIC50: >2.50E+5nMAssay Description:Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50280058(CHEMBL8948 | Sodium; 9-(4-fluoro-phenyl)-3,5-dihyd...)
Affinity DataIC50: >2.50E+5nMAssay Description:Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014345(CHEMBL11804 | Sodium; (E)-(3R,5S)-9,9-bis-(4-fluor...)
Affinity DataIC50: >3.00E+5nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50014347(CHEMBL321715 | Sodium; 9,9-bis-(4-fluoro-phenyl)-3...)
Affinity DataIC50: >3.00E+5nMAssay Description:In vitro inhibitory activity was measured against rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  49nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  390nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  7.65E+3nMAssay Description:Inhibitory activity against human plasmin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046342(2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin...)
Affinity DataEC50:  840nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  220nMAssay Description:Inhibitory activity against bovine pancreatic trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)
Affinity DataEC50:  26nMAssay Description:Inhibitory activity against bovine pancreatic trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046344(1-(3-Oxo-3-phenyl-propionyl)-pyrrolidine-2-carboxy...)
Affinity DataEC50:  590nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046348(1-(4-Oxo-4-pyridin-3-yl-butyryl)-pyrrolidine-2-car...)
Affinity DataEC50:  1.17E+3nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046346(1-(2-Oxo-5-phenyl-pentanoyl)-pyrrolidine-2-carboxy...)
Affinity DataEC50:  880nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)
Affinity DataEC50:  2.35E+3nMAssay Description:Inhibitory activity against human plasmin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046349(1-(4-Cyclohexyl-butyryl)-pyrrolidine-2-carboxylic ...)
Affinity DataEC50:  5.60E+4nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046347(1-(4-Oxo-4-thiophen-2-yl-butyryl)-pyrrolidine-2-ca...)
Affinity DataEC50:  590nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046350(1-(4-Cyclohexyl-4-oxo-butyryl)-pyrrolidine-2-carbo...)
Affinity DataEC50:  150nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164198(3,9-difluoro-12-(6-fluoromethyl-3,4,5-trihydroxyte...)
Affinity DataEC50:  76.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164199(3,9-difluoro-12-(5-fluoro-3,4,5-trihydroxy-6-hydro...)
Affinity DataEC50:  12.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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