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Found 173 with Last Name = 'ban' and Initial = 'hs'
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataKi:  740nMAssay Description:Competitive inhibition of human MDH1 expressed in Escherichia coli using oxaloacetic acid as substrate in presence of NADH after 30 mins by double re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataKi:  950nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataKi:  1.90E+3nMAssay Description:Competitive inhibition of MDH2 (unknown origin) using varying NADH level by oxaloacetate-dependent NADH oxidation based Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50031520(CHEMBL3359147)
Affinity DataKi:  4.30E+3nMAssay Description:Competitive inhibition of MDH2 (unknown origin) using varying NADH level by oxaloacetate-dependent NADH oxidation based Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308828(4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(pent-4...)
Affinity DataIC50:  2.53nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM31826(4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...)
Affinity DataIC50:  2.62nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308827(4-(3'-Chloro-4'-fluorophenylamino)-6-(hexa-4,5-die...)
Affinity DataIC50:  3.16nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308823(4-(3-Chloro-4-fluorophenylamino)-6-(octa-6,7-dieny...)
Affinity DataIC50:  4.45nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50426548(CHEMBL2323956)
Affinity DataIC50:  14nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308832(4-(3'-Chloro-4'-fluoroanilino)-6-(prop-2-ynyloxy)-...)
Affinity DataIC50:  14.8nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308833(6-(Buta-2,3-dienyloxy)-4-(3'-chlorophenylamino)-7-...)
Affinity DataIC50:  16.9nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308830(4-(3'-Chloroanilino)-7-methoxy-6-(pent-4-ynyloxy)q...)
Affinity DataIC50:  17.7nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  20.3nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308831(6-(Buta-2,3-dienyloxy)-4-(3'-chloro-4'-fluoroanili...)
Affinity DataIC50:  23.8nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308834(4-(3'-Chloroanilino)-7-methoxy-6-(prop-2-ynyloxy)q...)
Affinity DataIC50:  25.9nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308829(4-(3'-Chlorophenylamino)-6-(hexa-4,5-dienyloxy)-7-...)
Affinity DataIC50:  28.5nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant KDR at 1 uM by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308821(4-(3'-Chloro-4'-fluorophenylamino)-6-(hex-5-enylox...)
Affinity DataIC50:  32.6nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308824(4-(3'-Chloro-4'-fluoroanilino)-6-(hept-6-ynyloxy)-...)
Affinity DataIC50:  32.7nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50426547(CHEMBL2323957)
Affinity DataIC50:  34nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308825(4-(3'-chloro-4'-fluorophenylamino)-6-(hepta-5,6-di...)
Affinity DataIC50:  65.5nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308826(4-(3'-Chloro-4'-fluoroanilino)-6-(hex-5-ynyloxy)-7...)
Affinity DataIC50:  87.1nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308820(4-(3-Chloro-4-fluorophenylamino)-6-hexyloxy-7-meth...)
Affinity DataIC50:  106nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226373(1-(4-Amino-phenyl)-3-(3-benzo[1,3]dioxol-5-yl-4-ox...)
Affinity DataIC50:  214nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50426549(CHEMBL2323955)
Affinity DataIC50:  270nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226373(1-(4-Amino-phenyl)-3-(3-benzo[1,3]dioxol-5-yl-4-ox...)
Affinity DataIC50:  380nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50253289(CHEMBL4090212)
Affinity DataIC50:  600nMAssay Description:Inhibition of hypoxia-induced HIF1alpha (unknown origin) transcriptional activity expressed in human HCT116 cells by HRE luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226374(1-(4-Amino-phenyl)-3-[3-(4-hydroxy-phenyl)-4-oxo-2...)
Affinity DataIC50:  650nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50226372(1-(3-Benzo[1,3]dioxol-5-yl-4-oxo-2,4-dihydro-inden...)
Affinity DataIC50:  700nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50400095(CHEMBL2178407)
Affinity DataIC50:  740nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by HRE dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50253288(CHEMBL4074474)
Affinity DataIC50:  870nMAssay Description:Inhibition of hypoxia-induced HIF1alpha (unknown origin) transcriptional activity expressed in human HCT116 cells by HRE luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250223(CHEMBL4096306)
Affinity DataIC50:  920nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50253276(CHEMBL4101212)
Affinity DataIC50:  940nMAssay Description:Inhibition of hypoxia-induced HIF1alpha (unknown origin) transcriptional activity expressed in human HCT116 cells by HRE luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50308822(4-(3'-Chloro-4'-fluorophenylamino)-6-ethynyl-7-met...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant EGFR by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50250242(CHEMBL4068781)
Affinity DataIC50:  1.08E+3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by HRE dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50400094(CHEMBL427092)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of MDH1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250221(CHEMBL4080721)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250244(CHEMBL4091027)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50253294(CHEMBL4068303)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha (unknown origin) transcriptional activity expressed in human HCT116 cells by HRE luciferase reporter gene ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250235(CHEMBL4065526)
Affinity DataIC50:  1.14E+3nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250244(CHEMBL4091027)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, cytoplasmic(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250220(CHEMBL4098767)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of human MDH1 expressed in Escherichia coli after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250243(CHEMBL4074947)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalate dehydrogenase, mitochondrial(Homo sapiens (Human))
Dongguk University

Curated by ChEMBL
LigandPNGBDBM50250220(CHEMBL4098767)
Affinity DataIC50:  1.36E+3nMAssay Description:Inhibition of human MDH2 after 30 mins by oxaloacetate-dependent NADH oxidation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM91950(Chk1_82)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50250244(CHEMBL4091027)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells incubated for 12 hrs under hypoxic conditions by HRE dual-luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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