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Found 320 with Last Name = 'beese' and Initial = 'ls'
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.120nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130374(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.180nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.190nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130381(4-[Amino-(3-methyl-3H-imidazol-4-yl)-methyl]-2-[3-...)
Affinity DataIC50:  0.190nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130372(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.300nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130367((RR)-4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  0.380nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130368(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.410nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130378(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.460nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Duke University Medical Center

LigandPNGBDBM13307(1-Methyl-1H-imidazole-4-sulfonic Acid Benzyl-{2-[(...)
Affinity DataIC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130366(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  0.600nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130374(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  0.810nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14025((1R,2R,5R)-30-oxo-19,24-dioxa-2,6,10,12-tetraazahe...)
Affinity DataIC50: <1nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14023((1R,2R,5R)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50: <1nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14018((17R, 20R)-19,20,21,22-Tetrahydro-19-oxo-17H-15,-1...)
Affinity DataIC50: <1nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14014((5S)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19....)
Affinity DataIC50:  1.10nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130376(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  1.20nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14017((5R)-6-methyl-31-oxo-20-oxa-2,6,11,13-tetraazahexa...)
Affinity DataIC50:  1.20nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14015((5R)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19....)
Affinity DataIC50:  1.20nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Duke University Medical Center

LigandPNGBDBM31423(ethylenediamine scaffold, 4)
Affinity DataIC50:  1.20nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14008((11R)-32-oxo-25-oxa-8,12,16,18-tetraazahexacyclo[2...)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130371(2-[3-(3-Ethyl-2-oxo-azepan-3-yl)-phenoxy]-4-imidaz...)
Affinity DataIC50:  1.30nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14022((1R,2R,5R)-6-methyl-29-oxo-19-oxa-2,6,10,12-tetraa...)
Affinity DataIC50:  1.40nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  1.40nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50370231(CHEMBL1907916)
Affinity DataIC50:  1.40nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14007((6R)-24-bromo-27-oxo-20-oxa-3,7,11,13-tetraazapent...)
Affinity DataIC50:  1.40nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14024((1R,2R,5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  1.5nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14016((5S)-6-methyl-31-oxo-20-oxa-2,6,11,13-tetraazahexa...)
Affinity DataIC50:  1.5nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14010((20R)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130375(2-[3-(1-Acetyl-3-ethyl-azepan-3-yl)-phenoxy]-4-imi...)
Affinity DataIC50:  1.90nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14005((20R)-19,20,21,22-Tetrahydro-5-methyl-19-oxo-17H-1...)
Affinity DataIC50:  1.90nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130364(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  2nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14012((5S)-7,31-dioxo-20-oxa-2,6,11,13-tetraazahexacyclo...)
Affinity DataIC50:  2.10nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130372(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  2.10nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14013((5R)-7,31-dioxo-20-oxa-2,6,11,13-tetraazahexacyclo...)
Affinity DataIC50:  2.30nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  2.5nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14003((20R)-17-(3-Chlorophenyl)-19,20,21,22-tetrahydro-1...)
Affinity DataIC50:  2.5nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130378(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50:  2.90nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50100279(2-[3-(3-Ethyl-1-methyl-2-oxo-azepan-3-yl)-phenoxy]...)
Affinity DataIC50:  3nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Duke University Medical Center

LigandPNGBDBM31424(ethylenediamine scaffold, 5)
Affinity DataIC50:  3nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14009((20S)-19,20,21,22-Tetrahydro-19-oxo-5H-18,20-ethan...)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13998((20R)-19,20,21,22-Tetrahydro-19-oxo-17H-18,20-etha...)
Affinity DataIC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14020((1R,2R,5S)-29-oxo-19-oxa-2,6,10,12-tetraazahexacyc...)
Affinity DataIC50:  3.60nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50143599(2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]...)
Affinity DataIC50:  3.60nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
LigandPNGBDBM50409707(CHEMBL2111612)
Affinity DataIC50:  4.5nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14011((5S)-6-methyl-30-oxo-19-oxa-2,6,10,12-tetraazahexa...)
Affinity DataIC50:  4.90nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM14026((1R,2R,5S)-30-oxo-19,24-dioxa-2,6,10,12-tetraazahe...)
Affinity DataIC50:  4.90nMAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Duke University Medical Center

LigandPNGBDBM31425(ethylenediamine scaffold, 7)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays for PfPFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). An amount of 1 uM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50130367((RR)-4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethy...)
Affinity DataIC50:  5.10nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
LigandPNGBDBM14014((5S)-31-oxo-20-oxa-2,6,11,13-tetraazahexacyclo[19....)
Affinity DataIC50:  5.5nMAssay Description:The enzymatic reaction between [3H]GGPP and a biotinylated peptide was carried out in the presence of 5 mM ATP and varying concentrations of inhibit...More data for this Ligand-Target Pair
LigandPNGBDBM50370231(CHEMBL1907916)
Affinity DataIC50:  5.80nMAssay Description:Concentration required to inhibit recombinant human geranylgeranyl transferase type I (GGTase-I) catalyzed incorporation of [3H]GGPP to the C-terminu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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