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Found 1135 with Last Name = 'billedeau' and Initial = 'r'
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284753((R)-N*1*-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-e...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50063918((2R,3S)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-1-methyl...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284753((R)-N*1*-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-e...)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284755(2-[(Formyl-hydroxy-amino)-methyl]-4-methyl-pentano...)
Affinity DataKi:  1nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284755(2-[(Formyl-hydroxy-amino)-methyl]-4-methyl-pentano...)
Affinity DataKi:  2nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284754((S)-2-Mercaptomethyl-4-methyl-pentanoic acid ((S)-...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284753((R)-N*1*-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-e...)
Affinity DataKi:  3nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  3nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284751(CHEMBL30804 | [(S)-4-Methyl-2-((S)-9-oxo-1,8-diaza...)
Affinity DataKi:  4nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284753((R)-N*1*-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-e...)
Affinity DataKi:  5nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284751(CHEMBL30804 | [(S)-4-Methyl-2-((S)-9-oxo-1,8-diaza...)
Affinity DataKi:  5nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50086884((R)-N*4*-Hydroxy-2-isobutyl-N*1*-((S)-9-oxo-1,8-di...)
Affinity DataKi:  9nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284751(CHEMBL30804 | [(S)-4-Methyl-2-((S)-9-oxo-1,8-diaza...)
Affinity DataKi:  14nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284756((R)-5-Methyl-3-((S)-9-oxo-1,8-diaza-tricyclo[10.6....)
Affinity DataKi:  14nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284755(2-[(Formyl-hydroxy-amino)-methyl]-4-methyl-pentano...)
Affinity DataKi:  15nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284755(2-[(Formyl-hydroxy-amino)-methyl]-4-methyl-pentano...)
Affinity DataKi:  18nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284750((R)-2-[(S)-3-Methyl-1-((S)-9-oxo-1,8-diaza-tricycl...)
Affinity DataKi:  20nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284756((R)-5-Methyl-3-((S)-9-oxo-1,8-diaza-tricyclo[10.6....)
Affinity DataKi:  25nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284751(CHEMBL30804 | [(S)-4-Methyl-2-((S)-9-oxo-1,8-diaza...)
Affinity DataKi:  78nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284752(CHEMBL31164 | {(S)-2-[(S)-1-Hexylcarbamoyl-2-(1H-i...)
Affinity DataKi:  102nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284754((S)-2-Mercaptomethyl-4-methyl-pentanoic acid ((S)-...)
Affinity DataKi:  114nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284756((R)-5-Methyl-3-((S)-9-oxo-1,8-diaza-tricyclo[10.6....)
Affinity DataKi:  115nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeutrophil collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284757((R)-3-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-ethy...)
Affinity DataKi:  163nMAssay Description:Inhibition of human Matrix metalloproteinase-8More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284757((R)-3-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-ethy...)
Affinity DataKi:  171nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284752(CHEMBL31164 | {(S)-2-[(S)-1-Hexylcarbamoyl-2-(1H-i...)
Affinity DataKi:  300nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284752(CHEMBL31164 | {(S)-2-[(S)-1-Hexylcarbamoyl-2-(1H-i...)
Affinity DataKi:  432nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
Target72 kDa type IV collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284757((R)-3-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-ethy...)
Affinity DataKi:  472nMAssay Description:Inhibition of human neutrophil gelatinase, matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284757((R)-3-[(S)-1-Hexylcarbamoyl-2-(1H-indol-3-yl)-ethy...)
Affinity DataKi: >620nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284754((S)-2-Mercaptomethyl-4-methyl-pentanoic acid ((S)-...)
Affinity DataKi: >800nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284751(CHEMBL30804 | [(S)-4-Methyl-2-((S)-9-oxo-1,8-diaza...)
Affinity DataKi:  806nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284756((R)-5-Methyl-3-((S)-9-oxo-1,8-diaza-tricyclo[10.6....)
Affinity DataKi:  850nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284752(CHEMBL31164 | {(S)-2-[(S)-1-Hexylcarbamoyl-2-(1H-i...)
Affinity DataKi:  1.42E+3nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284758((2S,3R)-5-Methyl-3-((S)-1-methylcarbamoyl-2-phenyl...)
Affinity DataKi:  1.50E+3nMAssay Description:Inhibition of human fibroblast collagenase, matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails Article
TargetMatrilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284750((R)-2-[(S)-3-Methyl-1-((S)-9-oxo-1,8-diaza-tricycl...)
Affinity DataKi:  3.23E+3nMAssay Description:Inhibition of Matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284756((R)-5-Methyl-3-((S)-9-oxo-1,8-diaza-tricyclo[10.6....)
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284752(CHEMBL31164 | {(S)-2-[(S)-1-Hexylcarbamoyl-2-(1H-i...)
Affinity DataKi:  6.58E+3nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
TargetStromelysin-1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50284750((R)-2-[(S)-3-Methyl-1-((S)-9-oxo-1,8-diaza-tricycl...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails Article
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511228(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50:  0.0500nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511078(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50:  0.0600nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511224(2-(((2R,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-p...)
Affinity DataIC50:  0.0800nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122415(US8729078, I-25)
Affinity DataIC50:  0.0900nMpH: 7.2Assay Description:Plates assayed are 96-well polypropylene (Greiner) and 96-well 1.2 μm hydrophilic PVDF filter plates (Millipore). Concentrations reported here a...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122417(US8729078, I-27)
Affinity DataIC50:  0.0900nMpH: 7.2Assay Description:Plates assayed are 96-well polypropylene (Greiner) and 96-well 1.2 μm hydrophilic PVDF filter plates (Millipore). Concentrations reported here a...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511079(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50:  0.100nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511225(2-(((2R,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-y...)
Affinity DataIC50:  0.110nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM122442(US8729078, I-53)
Affinity DataIC50:  0.120nMpH: 7.2Assay Description:Plates assayed are 96-well polypropylene (Greiner) and 96-well 1.2 μm hydrophilic PVDF filter plates (Millipore). Concentrations reported here a...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511215(2-(((2R,3S,4R,5R)-5-(2-chloro-6-(isopropylamino)-9...)
Affinity DataIC50:  0.130nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-nucleotidase(Homo sapiens (Human))
Calithera Biosciences

US Patent
LigandPNGBDBM511232(2-(((2R,3S,4R,5R)-5-(5-chloro-7-((2,4-dimethoxyben...)
Affinity DataIC50:  0.140nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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