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Found 225 with Last Name = 'bischoff' and Initial = 's'
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50:  0.700nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451505(CHEMBL274422)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451503(CHEMBL12513)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2A heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)
Affinity DataIC50:  4nM EC50:  3.10nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)
Affinity DataIC50:  4nM EC50:  3.10nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451498(CHEMBL536107)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Hospital Zurich

Curated by ChEMBL
LigandPNGBDBM50073922(CHEMBL86313 | {(S)-1-[(7-Bromo-2,3-dioxo-1,2,3,4-t...)
Affinity DataIC50:  5nMAssay Description:Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Hospital Zurich

Curated by ChEMBL
LigandPNGBDBM50084064(CHEMBL167952 | {(S)-1-[(7-Chloro-2,3-dioxo-1,2,3,4...)
Affinity DataIC50:  6nMAssay Description:Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069471(CHEMBL357190 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  7nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Hospital Zurich

Curated by ChEMBL
LigandPNGBDBM50073930(CHEMBL82963 | {(S)-1-[(2,3-Dioxo-7-trifluoromethyl...)
Affinity DataIC50:  8nMAssay Description:Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Hospital Zurich

Curated by ChEMBL
LigandPNGBDBM50084062(CHEMBL354295 | {(S)-1-[(7-Iodo-2,3-dioxo-1,2,3,4-t...)
Affinity DataIC50:  8nMAssay Description:Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Homo sapiens (Human))
University Hospital Zurich

Curated by ChEMBL
LigandPNGBDBM50084063(CHEMBL162675 | {(S)-1-[(7-Fluoro-2,3-dioxo-1,2,3,4...)
Affinity DataIC50:  9nMAssay Description:Compound was evaluated for its binding affinity for the glycine binding site on N-methyl-D-aspartate glutamate receptor by using [3H]-MDL-105,519 bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  9nM EC50:  0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069495(CHEMBL147894 | N-(7-Chloro-2,3-dioxo-1,2,3,4-tetra...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069483(CHEMBL356281 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069459(CHEMBL413125 | Thiophene-3-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069465(CHEMBL343863 | Thiophene-2-carboxylic acid (7-brom...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069482(CHEMBL357916 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069458(CHEMBL147895 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  10nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20625(4-[(3E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol | ...)
Affinity DataIC50:  12nM EC50:  0.0600nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)
Affinity DataIC50:  13nM EC50:  24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20606((5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phe...)
Affinity DataIC50:  13nM EC50:  24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataIC50:  17nM EC50:  10.3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50451509(CHEMBL268920)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against Xenopus laevis oocyte expressing 1A/2B heteromeric human NMDA (hNMDA) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  19nM EC50:  16.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20586(2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-1,...)
Affinity DataIC50:  19nM EC50:  16.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069456(1-Methyl-1H-pyrrole-2-carboxylic acid (7-bromo-2,3...)
Affinity DataIC50:  20nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069478(3-Methyl-thiophene-2-carboxylic acid (7-bromo-2,3-...)
Affinity DataIC50:  20nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069461(CHEMBL357447 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  20nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20585(2-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1...)
Affinity DataIC50:  21nM EC50:  10.7nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataIC50:  21nM EC50:  32nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  22nM EC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  22nM EC50:  2.40nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  22nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nM EC50:  0.0200nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nMT: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  24nM EC50:  0.0700nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20594(2-(4-chlorophenyl)-1-methyl-1-{4-[2-(pyrrolidin-1-...)
Affinity DataIC50:  27nM EC50:  3.30nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20591(1-methyl-2-(4-methylphenyl)-1-{4-[2-(piperidin-1-y...)
Affinity DataIC50:  28nM EC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  28nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20588(1-methyl-2-phenyl-1-{4-[2-(piperidin-1-yl)ethoxy]p...)
Affinity DataIC50:  29nM EC50:  2.60nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069491(1-(2-Methoxy-phenyl)-3-(7-nitro-2,3-dioxo-1,2,3,4-...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069470(CHEMBL145606 | N-(7-Bromo-2,3-dioxo-1,2,3,4-tetrah...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069479(5-Methyl-thiophene-2-carboxylic acid (7-bromo-2,3-...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(RAT)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50069488(1-(4-Methoxy-phenyl)-3-(7-nitro-2,3-dioxo-1,2,3,4-...)
Affinity DataIC50:  30nMAssay Description:In vitro binding assay for the displacement of [3H]MDL-105519 from the glycine-site of NMDA receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20598(2-(3-hydroxyphenyl)-1-methyl-1-{4-[2-(pyrrolidin-1...)
Affinity DataIC50:  31nM EC50:  0.600nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Novartis Pharmaceuticals

LigandPNGBDBM20592(2-(4-fluorophenyl)-1-methyl-1-{4-[2-(pyrrolidin-1-...)
Affinity DataIC50:  31nM EC50:  1.60nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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