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Found 42 with Last Name = 'bok' and Initial = 's'
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575333(CHEMBL4857063)
Affinity DataIC50:  8nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575331(CHEMBL4868242)
Affinity DataIC50:  11nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575332(CHEMBL4869725)
Affinity DataIC50:  14nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575328(CHEMBL4868367)
Affinity DataIC50:  32nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387265(2,6- Difluoro-N-(2′- methyl-5′-(4-meth...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575327(CHEMBL4848840)
Affinity DataIC50:  34nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575326(CHEMBL4868517)
Affinity DataIC50:  50nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575329(CHEMBL4859192)
Affinity DataIC50:  55nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387270(2,6- Difluoro-N-(5-(2- methyl-5-(4- methyl-5-oxo-4...)
Affinity DataIC50:  64nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387269(2- Chloro-N-(5-(5-(5,5- dimethyl-4-oxo-4,5- dihydr...)
Affinity DataIC50:  65nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387261(N-(5′- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxa...)
Affinity DataIC50:  69nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50575331(CHEMBL4868242)
Affinity DataIC50:  76nMAssay Description:Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual pat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387266(N-(5′- (4-Ethyl-5-oxo-4,5- dihydro-1,3,4- ...)
Affinity DataIC50:  78nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387272(N-(5-(5- (5,5-dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Affinity DataIC50:  94nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50575336(CHEMBL4753998)
Affinity DataIC50:  119nMAssay Description:Inhibition of Orai1/STIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387297(US10292981, Example 121)
Affinity DataIC50:  150nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387294(US10292981, Example 78)
Affinity DataIC50:  171nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387281(N-(5-(5- (5,5-Dimethyl-4-oxo- 4,5-dihydroisoxazol-...)
Affinity DataIC50:  178nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575331(CHEMBL4868242)
Affinity DataIC50:  183nMAssay Description:Inhibition of IL2 in thapsigargin stimulated human whole bloodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575330(CHEMBL4872805)
Affinity DataIC50:  227nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM387290(N-(5- (5,5-Dimethyl-4,5- dihydroisoxazol-3- yl)-2-...)
Affinity DataIC50:  328nMAssay Description:Inhibition of PHA-stimulated IL2 secretion in human Jurkat T cells preincubated for 10 mins followed by PHA addition and measured after 20 to 24 hrs ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575331(CHEMBL4868242)
Affinity DataIC50:  695nMAssay Description:Inhibition of TNF-alpha in thapsigargin stimulated human whole bloodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein orai-2/Stromal interaction molecule 1(Homo sapiens)
Lupin

Curated by ChEMBL
LigandPNGBDBM50575336(CHEMBL4753998)
Affinity DataIC50:  895nMAssay Description:Inhibition of Orai2/STIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50575334(CHEMBL4863881)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of Orai1/STIM1 (unknown origin) expressed in HEK293 cells assessed as reduction in Ca2+-release activated Ca2+ entry current by manual pat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50291590(6-Hydroxy-17-(1-hydroxy-1-methyl-5-oxo-hex-3-enyl)...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibitory concentration of the compound was measured towards partially purified FPTase enzyme from rat brain using a scintillation proximity assay m...More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein orai-3/Stromal interaction molecule 1(Homo sapiens)
Lupin

Curated by ChEMBL
LigandPNGBDBM50575335(CHEMBL4570175)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human STIM1/Orai3 expressed in HEK293 cells assessed as reduction in Orai3 current by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50575335(CHEMBL4570175)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human STIM1/Orai1 expressed in HEK293 cells assessed as reduction in Orai1 current by electrophysiological methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM43866(2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,1...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of GST-Grb2 Tyrosine kinase SH2 domain binding to [3H]labeled-phosphopeptide (Ac-SpYVNK-NH-C(O)-CH2CH2H3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50071191(CHEMBL2373069 | actinomycin analogue)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of GST-Grb2 Tyrosine kinase SH2 domain binding to [3H]labeled-phosphopeptide (Ac-SpYVNK-NH-C(O)-CH2CH2H3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50240721((E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol...)
Affinity DataIC50:  6.30E+3nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50071190(2-Amino-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dica...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of GST-Grb2 Tyrosine kinase SH2 domain binding to [3H]labeled-phosphopeptide (Ac-SpYVNK-NH-C(O)-CH2CH2H3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Lupin

Curated by ChEMBL
LigandPNGBDBM50575331(CHEMBL4868242)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG by FLIPR TETRA methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM83205((E,2S,3R)-2-amino-4-octadecene-1,3-diol | (E,2S,3R...)
Affinity DataIC50:  1.15E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50244355((2S,3R)-2-amino-1,3-octadecanediol | (2S,3R)-2-ami...)
Affinity DataIC50:  1.29E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366476(CHEMBL1159544)
Affinity DataIC50:  1.97E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSqualene synthase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50269425(20(S)-protopanaxatriol | CHEMBL3349973 | CHEMBL457...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibitory concentration of the compound was measured towards partially purified FPTase enzyme from rat brain using a scintillation proximity assay m...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403614(CHEMBL2062153 | U-106305)
Affinity DataIC50:  2.50E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289521(CHEMBL37460 | Hexadecanoic acid ((3E,7E)-(1S,2R)-2...)
Affinity DataIC50:  4.68E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289524(CHEMBL418412 | Hexadecanoic acid ((3E,7E,9E)-(1S,2...)
Affinity DataIC50:  5.73E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289523(CHEMBL35292 | Hexadecanoic acid ((E)-(1S,2R)-2-hyd...)
Affinity DataIC50:  6.56E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289525(CHEMBL33771 | Hexadecanoic acid ((3E,7E)-(1S,2R)-2...)
Affinity DataIC50:  8.63E+4nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50289522(CHEMBL34522 | Sphingosylphosphorylchloline)
Affinity DataIC50:  1.57E+5nMAssay Description:Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP)More data for this Ligand-Target Pair
In DepthDetails Article