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Found 245 with Last Name = 'boyd' and Initial = 'h'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214370(CHEMBL227134 | N-(4-{2-[[2-(4-methanesulfonylamino...)
Affinity DataKi:  0.390nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214364(11-ethyl-1-(3-{[2-(4-methanesulfonylamino-phenoxy)...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  6.40nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214372(24-{[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50031720((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214373(24-{5-[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214369(24-{[(5-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM24226(1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxypheny...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214376(3,6-dihydroxy-N-(6-{[2-(4-methanesulfonamidophenox...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214371(24-{[(4-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214374(24-{2-[(6-{[2-(4-methanesulfonamidophenoxy)ethyl][...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataKi:  19nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50085629(2-[8-(4-Chloro-phenyl)-8-oxo-octylsulfanyl]-5-(1-m...)
Affinity DataKi:  41nMAssay Description:The compound was tested for inhibition of Lipoprotein-associated phospholipase A2 (Lp-PLA2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214366(3,6-bis(dimethylamino)-N-(6-{[2-(4-methanesulfonam...)
Affinity DataKi:  89nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214368(24-{[(3-{[2-(4-methanesulfonamidophenoxy)ethyl][2-...)
Affinity DataKi:  160nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM78577(BEPRIDIL HYDROCHLORIDE | Bepridil | MLS000028456 |...)
Affinity DataKi:  184nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Affinity DataKi:  190nMAssay Description:Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066694((S)-2-[(R)-7-(3-Chloro-9H-fluoren-9-yl)-2-hydroxy-...)
Affinity DataKi:  220nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM78577(BEPRIDIL HYDROCHLORIDE | Bepridil | MLS000028456 |...)
Affinity DataKi:  291nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066677((S)-2-{(R)-8-[4-Chloro-2-(3,4-dimethyl-pyrrol-1-yl...)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066677((S)-2-{(R)-8-[4-Chloro-2-(3,4-dimethyl-pyrrol-1-yl...)
Affinity DataKi:  300nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50117922((1S,2S)-2-(2-((3-(1H-benzo[d]imidazol-2-yl)propyl)...)
Affinity DataKi:  353nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066673((S)-2-[(R)-7-(5-Chloro-2-phenyl-indol-1-yl)-2-hydr...)
Affinity DataKi:  370nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066676((2S,3R)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-o...)
Affinity DataKi:  550nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066688((2S,3S)-2-[(R)-8-(2,4-Dichloro-phenyl)-2-hydroxy-o...)
Affinity DataKi:  620nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity was tested agianst rat ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity was tested agianst rat ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066682((S)-2-[(R)-7-(3-Chloro-carbazol-9-yl)-2-hydroxy-he...)
Affinity DataKi:  710nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066689((S)-2-[(R)-8-(5-Chloro-biphenyl-2-yl)-2-hydroxy-oc...)
Affinity DataKi:  750nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  770nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  770nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214375(3',6'-dihydroxy-N-[2-(4-methanesulfonamidophenoxy)...)
Affinity DataKi:  980nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214367((2-(N-ethylamidomethyl)-6,7,9,10,16,18-hexahydro-1...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50214363(3',6'-bis(dimethylamino)-N-[2-(4-methanesulfonamid...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066683((S)-2-((R)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity was tested agianst human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066672((S)-2-[(R)-8-(2-Benzyloxy-4-chloro-phenyl)-2-hydro...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066684((S)-2-[8-(2,4-Dichloro-phenyl)-2-oxo-octyl]-2-hydr...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibitory activity was tested agianst rat ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066685((S)-2-[(R)-7-(5,7-Dichloro-indol-1-yl)-2-hydroxy-h...)
Affinity DataKi:  1.80E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066692((S)-2-((S)-8-(2,4-dichlorophenyl)-2-hydroxyoctyl)-...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066687((S)-2-[(R)-8-(5-Chloro-4'-fluoro-biphenyl-2-yl)-2-...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066680((S)-2-[(R)-8-(5-Chloro-4'-methyl-biphenyl-2-yl)-2-...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Rattus norvegicus)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066697((S)-2-[8-(2,4-Dichloro-phenyl)-octyl]-2-hydroxy-su...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity was tested agianst ATP-Citrate Lyase (ACL) enzyme in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066686((S)-2-[(R)-7-(3-Benzyl-5-chloro-indol-1-yl)-2-hydr...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066678((S)-2-[(R)-7-(6-Chloro-1,2,3,4-tetrahydro-carbazol...)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  3.08E+3nMAssay Description:Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066693((S)-2-[(R)-8-(5-Chloro-indol-1-yl)-2-hydroxy-octyl...)
Affinity DataKi:  3.20E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066699((S)-2-[(R)-7-(5-Chloro-indol-1-yl)-2-hydroxy-hepty...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-citrate synthase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50066702((S)-2-[(R)-8-(4-Chloro-2-pyrrol-1-yl-phenyl)-2-hyd...)
Affinity DataKi:  3.90E+3nMAssay Description:Inhibitory activity against human recombinant ATP-Citrate Lyase (ACL) enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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