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Found 17603 with Last Name = 'brandhuber' and Initial = 'bj'
TargetGenome polyprotein(Hepacivirus C)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50495950(Danoprevir | R-05190591 | R05190591 | RO-5190591 |...)
Affinity DataKi:  45nMAssay Description:Inhibition of Hepatitis C virus genotype 1a NS3/4A protease A156T mutant expressed in Escherichia coli BL21 (DE3) cells assessed as substrate cleavag...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25619((1Z)-5-[1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]...)
Affinity DataIC50:  0.0200nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25636((1Z)-5-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyr...)
Affinity DataIC50:  0.0300nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25625((1S,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50:  0.0400nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25629(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.0500nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25626((1R,3R)-3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50:  0.0900nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25628(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.130nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25618((1Z)-5-[3-(pyridin-4-yl)-1H-pyrazol-4-yl]-2,3-dihy...)
Affinity DataIC50:  0.150nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25638((1Z)-5-[1-(oxan-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  0.220nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25641(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.230nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25624((1R,2R)-2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H...)
Affinity DataIC50:  0.330nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25637((1Z)-5-[1-(1-methylpiperidin-4-yl)-3-(pyridin-4-yl...)
Affinity DataIC50:  0.340nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25634(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.390nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25635((3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-...)
Affinity DataIC50:  0.470nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25620((1Z)-5-[1-methyl-5-(pyridin-4-yl)-1H-pyrazol-4-yl]...)
Affinity DataIC50:  0.480nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25631(2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.560nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25621((1Z)-5-[1-ethyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]-...)
Affinity DataIC50:  0.570nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50344470(6-(1-(8-azabicyclo[3.2.1]octan-3-yl)-3-(pyridin-4-...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50344473(CHEMBL1780170 | trans-4-(4-(2,4-dihydroindeno[1,2-...)
Affinity DataIC50:  0.660nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25640((1Z)-5-[1-(piperidin-3-ylmethyl)-3-(pyridin-4-yl)-...)
Affinity DataIC50:  0.850nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25630(3-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5...)
Affinity DataIC50:  0.870nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327782((R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-methyl-7H-p...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296817(US10112942, Example 552 | US10137124, Example 552 ...)
Affinity DataIC50:  1nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50332316((R)-2-amino-3-(4-chlorophenyl)-1-(4-((S)-5-methyl-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327785((R)-2-amino-1-(4-(5-chloro-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  1nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM296817(US10112942, Example 552 | US10137124, Example 552 ...)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM296817(US10112942, Example 552 | US10137124, Example 552 ...)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296817(US10112942, Example 552 | US10137124, Example 552 ...)
Affinity DataIC50:  1nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296817(US10112942, Example 552 | US10137124, Example 552 ...)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE¿-TK assay tec...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50398382(CHEMBL2177387)
Affinity DataIC50:  1nMAssay Description:Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50332329((S)-2-(4-chlorobenzyl)-3-(isopropylamino)-1-(4-((S...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25627((1Z)-5-[1-(2-methoxyethyl)-3-(pyridin-4-yl)-1H-pyr...)
Affinity DataIC50:  1.16nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25639((1Z)-5-[1-(piperidin-4-ylmethyl)-3-(pyridin-4-yl)-...)
Affinity DataIC50:  1.20nMpH: 7.2 T: 2°CAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50344483(6-(1-((3S,4S)-3-fluoropiperidin-4-yl)-3-(pyridin-4...)
Affinity DataIC50:  1.25nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50344480(6-(1-((3R,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50344480(6-(1-((3R,4R)-3-fluoropiperidin-4-yl)-3-(pyridin-4...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM50344464(6-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl)napht...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Array Biopharma

LigandPNGBDBM25653(4-(4-{2H,4H-indeno[1,2-c]pyrazol-6-yl}-1-methyl-1H...)
Affinity DataIC50:  1.5nMAssay Description:Activity of human recombinant B-Raf protein was assessed in vitro by assay of the incorporation of radiolabeled phosphate to recombinant MAP kinase (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50398372(CHEMBL2177378)
Affinity DataIC50:  2nMAssay Description:Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret (aa658-end)(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305704(2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...)
Affinity DataIC50:  2nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assay tec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327783((R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-ethyl-7H-py...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327784((R)-2-amino-3-(4-chlorophenyl)-1-(4-(5-cyclopropyl...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327787((S)-3-amino-2-(4-chlorobenzyl)-1-(4-(5-methyl-7H-p...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327792((S)-1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50327794((S)-3-amino-1-(4-(5-chloro-7H-pyrrolo[2,3-d]pyrimi...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKT1 by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50332318((R)-2-amino-3-(4-chloro-3-fluorophenyl)-1-(4-((S)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50332327(2-(4-chloro-3-fluorobenzyl)-3-(isopropylamino)-1-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Akt1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50398382(CHEMBL2177387)
Affinity DataIC50:  2nMAssay Description:Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt1 expressed in recombinant baculovirus system using fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM296818(US10112942, Example 553 | US10137124, Example 553 ...)
Affinity DataIC50:  2nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE™-TK assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM305704(2-chloro-N-((3S,4S)-1-(5- (3-cyano-6- ethoxypyrazo...)
Affinity DataIC50:  2nMAssay Description:Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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