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Found 942 with Last Name = 'campbell' and Initial = 'rm'
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50051653((5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataKi:  6.70nMAssay Description:Binding affinity towards rat A1 receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against binding of the [3H]-CGS-21,680 to human A2a receptor (hA2a) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080288(CHEMBL81616 | N-[2-(5,6-Dimethyl-2-phenyl-7H-pyrro...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against binding of the [3H]-DPCPX to human A1 receptor (hA1) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080288(CHEMBL81616 | N-[2-(5,6-Dimethyl-2-phenyl-7H-pyrro...)
Affinity DataKi:  23nMAssay Description:Inhibitory activity against binding of the [3H]-CGS-21,680 to human A2a receptor (hA2a) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080292(4-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidi...)
Affinity DataKi:  25nMAssay Description:Inhibitory activity against binding of the [3H]-DPCPX to human A1 receptor (hA1) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  70nMAssay Description:Inhibitory activity against binding of [3H]-DPCPX to human A1 receptor (hA1) using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080291((5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataKi:  132nMAssay Description:Inhibitory activity against binding of the [3H]-DPCPX to human A1 receptor (hA1) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080287(1-[2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataKi:  144nMAssay Description:Inhibitory activity against binding of the [3H]-DPCPX to human A1 receptor (hA1) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080287(1-[2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrim...)
Affinity DataKi:  215nMAssay Description:Inhibitory activity against binding of [3H]-DPCPX to human A1 receptor (hA1) using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080292(4-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidi...)
Affinity DataKi:  754nMAssay Description:Inhibitory activity against binding of [3H]-CGS-21,680 to human A2a receptor (hA2a) using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080289((R)-3-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyri...)
Affinity DataKi:  771nMAssay Description:Inhibitory activity against membranes from yeast cells transformed with human A1 receptor (hA1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080291((5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataKi:  811nMAssay Description:Inhibitory activity against binding of the [3H]-CGS-21,680 to human A2a receptor (hA2a) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080290((1R,2R)-2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]...)
Affinity DataKi:  896nMAssay Description:Inhibitory activity against binding of the [3H]-DPCPX to human A1 receptor (hA1) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080286((S)-2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyri...)
Affinity DataKi:  951nMAssay Description:Inhibitory activity against binding of the [3H]-DPCPX to human A1 receptor (hA1) radioligands using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080289((R)-3-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyri...)
Affinity DataKi:  962nMAssay Description:Inhibitory activity against binding of [3H]-DPCPX to human A1 receptor (hA1) using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50051653((5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-...)
Affinity DataKi:  981nMAssay Description:Inhibitory activity against binding of [3H]-DPCPX to human A1 receptor (hA1) using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Cadus Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50080286((S)-2-(5,6-Dimethyl-2-phenyl-7H-pyrrolo[2,3-d]pyri...)
Affinity DataKi:  1.14E+3nMAssay Description:Inhibitory activity against binding of [3H]-DPCPX to human A1 receptor (hA1) using competition binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474994(Bisarylmaleimide 1)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475007(Bisarylmaleimide 2)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475025(CHEMBL181339)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475024(CHEMBL181371)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475018(CHEMBL181518)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475031(CHEMBL359871)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150699(3-(9-fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)
Affinity DataIC50:  1.20nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475029(CHEMBL180779)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150700(7-(4-Imidazo[1,2-a]pyridin-3-yl-2,5-dioxo-2,5-dihy...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150698(3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475008(CHEMBL369090)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150698(3-(imidazo[1,2-a]pyridin-3-yl)-4-(2-(morpholine-4-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475022(CHEMBL361765)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474994(Bisarylmaleimide 1)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration to inhibit Ser396 phosphorylation of tau, a natural substrate of GSK-3 in SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150701(7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of Glycogen synthase kinase-3 beta dependent Tau protein serine-396 phosphorylation in human SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150701(7-(4-(H-imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475010(CHEMBL369316)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475001(CHEMBL368246)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475004(CHEMBL369572)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475014(CHEMBL361948)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Eli Lilly

LigandPNGBDBM6811(18,23-dimethyl-3,13,18-triazahexacyclo[14.7.0.0^{2...)
Affinity DataIC50:  2nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150702(3-Imidazo[1,2-a]pyridin-3-yl-4-[2-(piperidine-1-ca...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Glycogen synthase kinase-3 betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbINGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475006(CHEMBL178851)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50474996(CHEMBL178646)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373946(CHEMBL270657)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human recombinant p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50475000(CHEMBL181296)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against the Glycogen synthase kinase-3 More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50373967(CHEMBL442972)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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