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Found 1643 with Last Name = 'carr' and Initial = 'd'
LigandPNGBDBM50438628(CHEMBL2414299)
Affinity DataKi:  0.230nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438634(CHEMBL2414301)
Affinity DataKi:  0.360nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403075(CHEMBL2216902)
Affinity DataKi:  0.470nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403074(CHEMBL2216903)
Affinity DataKi:  0.580nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438630(CHEMBL2414297)
Affinity DataKi:  0.590nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50001468((S)-3-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phen...)
Affinity DataKi:  0.730nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438633(CHEMBL2414294)
Affinity DataKi:  0.800nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438635(CHEMBL2414300)
Affinity DataKi:  0.880nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438629(CHEMBL2414298)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438637(CHEMBL2414238)
Affinity DataKi:  1.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396642(CHEMBL2171939)
Affinity DataKi:  1.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396628(CHEMBL2171944)
Affinity DataKi:  2nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396633(CHEMBL2171952)
Affinity DataKi:  2nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438636(CHEMBL2414239)
Affinity DataKi:  2.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50059841((S)-1-[(S)-2-[2-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hy...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor muMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438631(CHEMBL2414296)
Affinity DataKi:  3.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50139013((S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor muMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50060070((S)-2-Amino-N-{(R)-1-[(S)-1-((S)-1-carbamoyl-2-phe...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor muMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50394894(CHEMBL2165501)
Affinity DataKi:  5.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50166347((S)-N-{(S)-1-[(S)-1-(Carbamoylmethyl-carbamoyl)-2-...)
Affinity DataKi:  10.4nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  12.5nMAssay Description:Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
LigandPNGBDBM50438632(CHEMBL2414295)
Affinity DataKi:  13nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  15.1nMAssay Description:Binding affinity to human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50085658((2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin...)
Affinity DataKi:  15.3nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301329(5-chloro-6-(4-((2S)-1-(4-chlorobenzyl)-2-methylpip...)
Affinity DataKi:  16nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  18.3nMAssay Description:Displacement of [3H]CHA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50202575(1-deoxy-1-{2-chloro-6-[N'-(2-thiophen-2-yl-acetyl)...)
Affinity DataKi:  25nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301330(5-chloro-6-(4-((2S)-1-(4-chlorobenzyl)-2-methylpip...)
Affinity DataKi:  32nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21220((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,...)
Affinity DataKi:  34.6nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301351(5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)pi...)
Affinity DataKi:  35nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071558(3-Hydroxy-6-methyl-4-[(2S,3S)-3-methyl-2-(2-naphth...)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against plasmepsin-2 from Plasmodium falciparumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071554(3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl...)
Affinity DataKi:  50nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Catania

Curated by ChEMBL
LigandPNGBDBM50166345(6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carbox...)
Affinity DataKi:  57.8nMAssay Description:Inhibition of [3H]-naloxone binding to rat brain homogenate Opioid receptor muMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Dipartimento Di Scienze Farmaceutiche

Curated by ChEMBL
LigandPNGBDBM50202575(1-deoxy-1-{2-chloro-6-[N'-(2-thiophen-2-yl-acetyl)...)
Affinity DataKi:  62nMAssay Description:Displacement of [3H]CHA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301340(5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-yl)pi...)
Affinity DataKi:  70nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301341(6-(4-(1-(4-bromobenzyl)piperidin-4-yl)piperazin-1-...)
Affinity DataKi:  85nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301328((R)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-y...)
Affinity DataKi:  86nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301326(5-chloro-6-(4-(1-(4-cyanobenzyl)piperidin-4-yl)pip...)
Affinity DataKi:  90nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071554(3-Hydroxy-4-[(2S,3S)-3-methyl-2-(2-naphthalen-2-yl...)
Affinity DataKi:  90nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Amarit Bioscience

Curated by ChEMBL
LigandPNGBDBM50249090(3,3'-(5-fluoropyrimidine-2,4-diyl)bis(azanediyl)di...)
Affinity DataKi:  96nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071546(3-Hydroxy-6-methyl-4-{(S)-2-[2-(naphthalen-2-yloxy...)
Affinity DataKi:  110nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301335(5-chloro-6-(4-(1-(4-cyanobenzyl)piperidin-4-yl)pip...)
Affinity DataKi:  110nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396642(CHEMBL2171939)
Affinity DataKi:  110nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071561(3-Hydroxy-4-{(2S,3S)-3-methyl-2-[2-(naphthalen-2-y...)
Affinity DataKi:  110nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301344(5-chloro-6-(4-(1-(4-methoxybenzyl)piperidin-4-yl)p...)
Affinity DataKi:  120nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301348(CHEMBL577409 | N-benzyl-5-chloro-6-(4-(1-(4-chloro...)
Affinity DataKi:  140nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50438632(CHEMBL2414295)
Affinity DataKi:  157nMAssay Description:Inhibition of PI3Kalpha (unknown origin) assessed as formation of PIP3 by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50301342(5-chloro-6-(4-(1-(4-fluorobenzyl)piperidin-4-yl)pi...)
Affinity DataKi:  160nMAssay Description:Displacement of 125I-IP10 from recombinant human CXCR3 receptor expressed in Ba/F3 cell membrane after 1 to 4 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071555(3-Hydroxy-4-{(2S,3S)-1-hydroxy-3-methyl-2-[2-(naph...)
Affinity DataKi:  180nMAssay Description:In vitro inhibition of plasmepsin-2 from Plasmodium falciparum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Pharmacopeia

Curated by ChEMBL
LigandPNGBDBM50071559((S)-2-[2-(Naphthalen-2-yloxy)-acetylamino]-pentane...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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