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Found 3408 with Last Name = 'castro' and Initial = 'a'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29864(N-(Pyridin-2-yl) arylsulfonamide, 26)
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121472(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  1.60nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29863(N-(Pyridin-2-yl) arylsulfonamide, 25)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29862(N-(Pyridin-2-yl) arylsulfonamide, 24)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121475(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  2.5nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121461(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  3nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29860(N-(Pyridin-2-yl) arylsulfonamide, 22)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121484(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  4.70nMAssay Description:Competitive inhibition of GnRH-stimulated extracellular acidification in cells expressing recombinant rat GnRH receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121484(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  4.70nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29866(N-(Pyridin-2-yl) arylsulfonamide, 28)
Affinity DataKi:  4.80nM ΔG°:  -47.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29858(N-(Pyridin-2-yl) arylsulfonamide, 20)
Affinity DataKi:  5.80nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121464(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  6nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50095181(CHEMBL96680 | N-(3-Aminomethyl-phenyl)-furan-2-car...)
Affinity DataKi:  6.30nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29861(N-(Pyridin-2-yl) arylsulfonamide, 23)
Affinity DataKi:  6.60nM ΔG°:  -46.2kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121462(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  7nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121466(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  7.5nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121472(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  8nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50095172(CHEMBL262040 | N-(3-Aminomethyl-phenyl)-thiophene-...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121470(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  9nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121484(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  9.30nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29865(N-(Pyridin-2-yl) arylsulfonamide, 27)
Affinity DataKi:  9.80nM ΔG°:  -45.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121475(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121483(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  11nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50271363(CHEMBL476988 | N-(3-Aminomethyl-phenyl)-2-methylsu...)
Affinity DataKi:  11nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121483(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  11nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50271464(CHEMBL455310 | N-(3-Aminomethyl-phenyl)-2-fluoro-a...)
Affinity DataKi:  11nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121081(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  13nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121462(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50271882(2-{2-[4-(2-CARBAMIMIDOYLSULFANYL-ETHYL)-PHENYL]-ET...)
Affinity DataKi:  16nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121090(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  16nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121103(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  17nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121096(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  20nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM29857(N-(Pyridin-2-yl) arylsulfonamide, 19)
Affinity DataKi:  20nM ΔG°:  -43.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121481(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  22nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121087(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  24nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121099(4-({[5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-n...)
Affinity DataKi:  24nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121479(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  26nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121465(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  28nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50055281(2-Ethyl-isothiourea | CHEMBL321691 | ETHYLISOTHIOU...)
Affinity DataKi:  29nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121469(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  29nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)
Affinity DataKi:  32.5nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121478(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  33nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121464(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  33nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121467(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  35nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50271827(2-Isopropyl-isothiourea | CHEMBL483091 | S-ISOPROP...)
Affinity DataKi:  37nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica

Curated by ChEMBL
LigandPNGBDBM50138977(CHEMBL419740 | N-(3-Aminomethyl-phenyl)-acetamidin...)
Affinity DataKi:  40nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121478(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  40nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121091(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  40nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50224310(5-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  40nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121086(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  42nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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