Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nM ΔG°: -49.6kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 1.90nM ΔG°: -49.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4nM ΔG°: -47.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:Competitive inhibition of GnRH-stimulated extracellular acidification in cells expressing recombinant rat GnRH receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 4.80nM ΔG°: -47.0kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 5.80nM ΔG°: -46.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 6nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 6.30nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
Affinity DataKi: 6.60nM ΔG°: -46.2kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 7nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 7.5nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 8.70nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 9.30nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 9.80nM ΔG°: -45.3kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
Affinity DataKi: 20nM ΔG°: -43.5kJ/molepH: 8.0 T: 2°CAssay Description:The enzyme assay was performed in a round-bottom 96-well plate. The enzyme was pre-incubated in the assay buffer in the presence of NADPH and inhibit...More data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 24nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 29nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 29nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Research Triangle Institute
Curated by ChEMBL
Research Triangle Institute
Curated by ChEMBL
Affinity DataKi: 32.5nMAssay Description:Displacement of [125I]iodoMLA from rat cerebral cortex alpha7 nAChR at 50 nM incubated for 2 hrs by microplate scintillation assayMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:In vitro binding affinity towards rat gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 35nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 37nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Instituto De QuíMica MéDica
Curated by ChEMBL
Instituto De QuíMica MéDica
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrullineMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:In vitro binding affinity towards human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Agouron Pharmaceuticals
Curated by ChEMBL
Agouron Pharmaceuticals
Curated by ChEMBL
Affinity DataKi: 42nMAssay Description:In vitro binding affinity to human gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair