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Found 330 with Last Name = 'chai' and Initial = 'h'
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50160917(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)
Affinity DataKi:  0.300nMAssay Description:Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397031(CHEMBL2171190)
Affinity DataKi:  8.40E+3nMAssay Description:Competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki intercept using Histone H4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397030(CHEMBL2171189)
Affinity DataKi:  1.13E+4nMAssay Description:Competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki intercept using Histone H4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397030(CHEMBL2171189)
Affinity DataKi:  2.97E+4nMAssay Description:Non competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki slope using SAM preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 1 [11-371](Homo sapiens (Human))
Georgia State University

Curated by ChEMBL
LigandPNGBDBM50397031(CHEMBL2171190)
Affinity DataKi: >2.57E+5nMAssay Description:Non competitive inhibition of histidine tagged recombinant PRMT1 expressed in Escherichia coli BL21 (DE3) cells assessed as Ki slope using SAM preinc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50160917(3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020910(CHEMBL3287268 | US9216962, CFH395)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020908(CHEMBL3287266 | US9216962, CFH367)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020894(CHEMBL3287252 | US9216962, CFH355)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020896(CHEMBL3287254 | US9216962, CFH383)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50148911((3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hyd...)
Affinity DataIC50:  31nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020912(Largazole Thiol)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020905(CHEMBL3287263 | US9216962, CFH461)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020915(CHEMBL3287008 | US9216962, CFH412-S)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020904(CHEMBL3287262 | US9216962, CFH417)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  70nMAssay Description:Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020897(CHEMBL3287255 | US9216962, CFH367-C)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  75nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  75nMAssay Description:Inhibition of NFkappa p50 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by chem...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020913(CHEMBL3287006)
Affinity DataIC50:  77nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020904(CHEMBL3287262 | US9216962, CFH417)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50196926(CHEMBL438139 | Rocaglamide | US10085988, Compound ...)
Affinity DataIC50:  80nMAssay Description:Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020913(CHEMBL3287006)
Affinity DataIC50:  85nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020915(CHEMBL3287008 | US9216962, CFH412-S)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM28681(5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...)
Affinity DataIC50:  92nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020890(CHEMBL3287250 | US9216962, CFH382)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179235(2-{5-[4-(7-propyl-3-trifluoromethylbenzo[d]isoxazo...)
Affinity DataIC50:  105nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020908(CHEMBL3287266 | US9216962, CFH367)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020889(CHEMBL3287023 | US9216962, CFH326)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020899(CHEMBL3287257 | US9216962, CFH403)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020872(CHEMBL3287010 | US9216962, CFH426-S)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020903(CHEMBL3287261 | US9216962, CFH448-P)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020909(CHEMBL3287267 | US9216962, CFH352)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020872(CHEMBL3287010 | US9216962, CFH426-S)
Affinity DataIC50:  120nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179229(2-{5-[3-(3-phenyl-7-propylbenzo[d]isoxazol-6-yloxy...)
Affinity DataIC50:  120nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179225(2-{4-[3-(3-phenyl-7-propylbenzo[d]isoxazol-6-yloxy...)
Affinity DataIC50:  127nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020910(CHEMBL3287268 | US9216962, CFH395)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020885(CHEMBL3287022 | US9216962, CFH340-4)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50179236(2-(5-(3-(7-propyl-3-(trifluoromethyl)benzo[d]isoxa...)
Affinity DataIC50:  152nMAssay Description:Displacement of [3H]-rosiglitazone from human PPAR gamma by SPA assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020902(CHEMBL3287260 | US9216962, CFH437)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020905(CHEMBL3287263 | US9216962, CFH461)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020906(CHEMBL3287264)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020910(CHEMBL3287268 | US9216962, CFH395)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020906(CHEMBL3287264)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020911(CHEMBL3287269 | US9216962, CFH409-A)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(epsilon-acetyl)-AMC as substrate after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Chinese National Center For Drug Screening

Curated by ChEMBL
LigandPNGBDBM50020896(CHEMBL3287254 | US9216962, CFH383)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human HDAC3 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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