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Found 100 with Last Name = 'chang' and Initial = 'z'
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81917(BX-2819)
Affinity DataIC50:  0.0400nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81914(Ethyl carbamate analog, 3)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81916(lspropyl analog, 5)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81915(Ethyl analog, 4)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81913(Unsubstituted phenyl ring analog, 2)
Affinity DataIC50:  0.5nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17051(BX-795 | BX-795, 3 | N-(3-{[5-iodo-4-({3-[(thiophe...)
Affinity DataIC50:  6nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312614(4-methyl-5-(6-{[4-(methylsulfonyl)piperazin-1-yl]m...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Berlex Biosciences

LigandPNGBDBM17052(BX-912 | N-{3-[(5-bromo-4-{[2-(1H-imidazol-4-yl)et...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312609((3-(6-((4-(Methylsulfonyl)piperazin-1-yl)methyl)-4...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kdelta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312616(2-[2-(2-Amino-4-methyl-pyrimidin-5-yl)-4-morpholin...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312612(3-[6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-mo...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312611(6-(4-Methanesulfonyl-piperazin-1-ylmethyl)-4-morph...)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312615(2-(2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50:  22nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abdulaziz University For Health Sciences

Curated by ChEMBL
LigandPNGBDBM50467209(CHEMBL4291446)
Affinity DataIC50:  23nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50312605(2-(2-(2-amino-4-methylpyrimidin-5-yl)-4-morpholino...)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312617(1-(2-(1H-Indazol-4-yl)-4-morpholinothieno[3,2-d]py...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50312618((2-(1H-indazol-4-yl)-4-morpholinothieno[3,2-d]pyri...)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant PI3Kalpha assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant mTOR by FRETMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25028(4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpipera...)
Affinity DataIC50:  32nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
LigandPNGBDBM50312607(5-(6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant PI3Kgamma assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abdulaziz University For Health Sciences

Curated by ChEMBL
LigandPNGBDBM50467207(CHEMBL4288828)
Affinity DataIC50:  34nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50312606(5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-...)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant PI3Kbeta assessed as PIP3 product formation by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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