Compile Data Set for Download or QSAR
maximum 50k data
Found 243 with Last Name = 'chao' and Initial = 'e'
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataKi:  398nMAssay Description:Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataKi:  1.59E+3nMAssay Description:Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22427(4-[(1Z)-4-azido-1-{4-[2-(dimethylamino)ethoxy]phen...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127221(CHEMBL289887 | {2-Methyl-4-[4-methyl-2-(4-trifluor...)
Affinity DataIC50:  3nMAssay Description:Maximum transcriptional activation of human PPAR delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22423(4-[(1Z)-4-chloro-1-{4-[2-(dimethylamino)ethoxy]phe...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22427(4-[(1Z)-4-azido-1-{4-[2-(dimethylamino)ethoxy]phen...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22429(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-(m...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22428(4-[(1Z)-5-azido-1-{4-[2-(dimethylamino)ethoxy]phen...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22423(4-[(1Z)-4-chloro-1-{4-[2-(dimethylamino)ethoxy]phe...)
Affinity DataIC50:  13nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252816(2-(4-{Butyl[3-(2-hydroxyethoxy)benzyl]amino}phenyl...)
Affinity DataIC50:  15nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM21673(N-[4-(1,1,1,3,3,4,4,5,5,5-decafluoro-2-hydroxypent...)
Affinity DataIC50:  20nM EC50:  10nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22426((5Z)-6-{4-[2-(dimethylamino)ethoxy]phenyl}-6-(4-hy...)
Affinity DataIC50:  25nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM21670(N-[4-(1-cyclohexyl-2,2,2-trifluoro-1-hydroxyethyl)...)
Affinity DataIC50:  25nM EC50:  3nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252850(2-{4-[Butyl(pyridin-4-ylmethyl)amino]phenyl}-1,1,1...)
Affinity DataIC50:  25nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252939(2-[4-(Butyl{[3-chloro-4,5-bis(methyloxy)phenyl]met...)
Affinity DataIC50:  25nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252817(2-{4-[Butyl(pyridin-2-ylmethyl)amino]phenyl}-1,1,1...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19992(2-[3-[3-[[2-chloro-3-(trifluoromethyl)phenyl]methy...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252852(3-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252967(2-{4-[Butyl(3,5-dichloro-4-methoxybenzyl)amino]phe...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252940(4-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252941(2-{4-[Butyl(3,5-dichlorobenzyl)amino]phenyl}-1,1,1...)
Affinity DataIC50:  30nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127223(CHEMBL37013 | {2-Methyl-4-[4-methyl-2-(4-trifluoro...)
Affinity DataIC50:  30nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127215(3-{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazo...)
Affinity DataIC50:  30nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252851(2-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  40nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataIC50:  40nM EC50:  13nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252815(2-{4-[Benzyl(butyl)amino]phenyl}-1,1,1,3,3,3-hexaf...)
Affinity DataIC50:  40nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252938(4-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  45nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252908(4-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  50nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127218(3-{2-Methyl-4-[4-methyl-2-(4-trifluoromethyl-pheny...)
Affinity DataIC50:  60nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
University of North Carolina At Chapel Hill

LigandPNGBDBM21671(N-[4-(2,2,2-trifluoro-1-hydroxy-1-phenylethyl)phen...)
Affinity DataIC50:  63nM EC50:  16nMpH: 8.0 T: 2°CAssay Description:Polylysine YiO imaging beads (Amersham, GE Healthcare) were coated with histidine-tagged WT PXR LBD. Nonspecific binding sites were blocked with BSA....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataIC50:  75nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRalpha ligand binding domainMore data for this Ligand-Target Pair
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22435(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...)
Affinity DataIC50:  79nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22436(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-6-hy...)
Affinity DataIC50:  79nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127224(3-{4-[4-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol...)
Affinity DataIC50:  90nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252850(2-{4-[Butyl(pyridin-4-ylmethyl)amino]phenyl}-1,1,1...)
Affinity DataIC50:  90nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRalpha ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127220(CHEMBL37495 | {4-[4-Methyl-2-(4-trifluoromethyl-ph...)
Affinity DataIC50:  90nMAssay Description:Binding affinity for human PPAR delta receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM22424(4-[(1Z)-5-chloro-1-{4-[2-(dimethylamino)ethoxy]phe...)
Affinity DataIC50:  100nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252816(2-(4-{Butyl[3-(2-hydroxyethoxy)benzyl]amino}phenyl...)
Affinity DataIC50:  115nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRalpha ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252907(2-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  115nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252817(2-{4-[Butyl(pyridin-2-ylmethyl)amino]phenyl}-1,1,1...)
Affinity DataIC50:  120nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRalpha ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252854(2-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  120nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22424(4-[(1Z)-5-chloro-1-{4-[2-(dimethylamino)ethoxy]phe...)
Affinity DataIC50:  130nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen-related receptor gamma(Homo sapiens (Human))
Gsk

LigandPNGBDBM22428(4-[(1Z)-5-azido-1-{4-[2-(dimethylamino)ethoxy]phen...)
Affinity DataIC50:  160nMpH: 7.4 T: 2°CAssay Description:Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252852(3-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  160nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRalpha ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50252905(2-[(Butyl{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluor...)
Affinity DataIC50:  165nMAssay Description:Displacement of [N-methyl-3H]GW0438 from human biotinylated LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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