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Found 4064 with Last Name = 'chen' and Initial = 'r'
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231595(CHEMBL4092832)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231590(CHEMBL4063997)
Affinity DataKi:  0.280nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Rattus norvegicus (Rat))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50099679(3-Bromo-2-hydroxy-2-methyl-N-(4-nitro-3-trifluorom...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-MIB from cytosolic Androgen receptor derived from Sprague-Dawley rat prostate in presence of triamcinolone by competitive bindin...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50152234(CHEMBL184061 | N*5*-{2-[4-(2,4-Difluoro-phenyl)-pi...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50152234(CHEMBL184061 | N*5*-{2-[4-(2,4-Difluoro-phenyl)-pi...)
Affinity DataKi:  0.330nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM21190(4-(2-{[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594916(CHEMBL469759)
Affinity DataKi:  0.540nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594922(CHEMBL5170697)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to recombinant human Androgen receptor assessed as inhibition constant by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231595(CHEMBL4092832)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18524(6-[bis(2,2,2-trifluoroethyl)amino]-4-(trifluoromet...)
Affinity DataKi:  1nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50152237(2-Furan-2-yl-N*5*-[3-(4-phenyl-piperazin-1-yl)-pro...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50152237(2-Furan-2-yl-N*5*-[3-(4-phenyl-piperazin-1-yl)-pro...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594913(CHEMBL5184779)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232997((S)-(-)-endo-2-norbornyl-N-n-butylcarbamate)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231589(CHEMBL4073088)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50005429(CHEMBL4070288)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]naloxone from recombinant human MOR expressed in HEK cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231597(CHEMBL4102409)
Affinity DataKi:  2.30nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232998((R)-(+)-endo-2-norbornyl-N-n-butylcarbamate | rac-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50150077(2-((1H-imidazol-2-yl)methylthio)-6-amino-4-phenylp...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]-DPCPX from human A1 receptor expressed in CHO cell membranes measured after 3 hrs by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of SARS-CoV-2 3CL protease assessed as inhibition constantMore data for this Ligand-Target Pair
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
University of Virginia

Curated by PDSP Ki Database
LigandPNGBDBM81801(CAS_5283121 | LTC4 | NSC_5283121)
Affinity DataKi:  3.35nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
University of Virginia

Curated by PDSP Ki Database
LigandPNGBDBM50292408((R-(R*,S*-(E,E,Z,Z)))-N-(S-(1-(4-Carboxy-1-hydroxy...)
Affinity DataKi:  3.48nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231709(CHEMBL4083067)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50532555(CHEMBL3937413)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50532555(CHEMBL3937413)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-ZM241385 from wild type human adenosine receptor A2a expressed in HEK293 cell membranes after 240 mins by scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594917(CHEMBL511130)
Affinity DataKi:  4nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50594918(CHEMBL4754501)
Affinity DataKi:  4nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50007985(CHEMBL4097865)
Affinity DataKi:  4.70nMAssay Description:Agonist activity at human MOR expressed in HEK293 cells assessed as inhibition of forskolin-induced adenylyl cyclase-mediated cAMP accumulation after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232998((R)-(+)-endo-2-norbornyl-N-n-butylcarbamate | rac-...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50564520(CHEMBL4796569)
Affinity DataKi:  5.10nMAssay Description:Inhibition of His-tagged human full length PI3Kalpha coexpressed with p85 alpha in baculovirus expression system using PIP2 peptide as substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50042064(CHEMBL4097466)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]naloxone from recombinant human MOR expressed in HEK cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231707(CHEMBL4085564)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231707(CHEMBL4085564)
Affinity DataKi:  5.60nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231588(CHEMBL4084453)
Affinity DataKi:  5.90nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18664((2R)-3-(4-fluorophenoxy)-2-hydroxy-2-methyl-N-[4-n...)
Affinity DataKi:  6nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
Addiction Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50013388(6-Ethyl-3-(1-hydroxy-cyclopropylmethyl)-11,11-dime...)
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50015426(CHEMBL4070750)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]naloxone from recombinant human MOR expressed in HEK cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231590(CHEMBL4063997)
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50009239(CHEMBL4092125)
Affinity DataKi:  6.90nMAssay Description:Displacement of [3H]naloxone from recombinant human MOR expressed in HEK cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50150077(2-((1H-imidazol-2-yl)methylthio)-6-amino-4-phenylp...)
Affinity DataKi:  7.40nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes measured after 3 hrs by radioligand binding assayMore data for this Ligand-Target Pair
TargetCannabinoid receptor 2(Homo sapiens (Human))
The University Of Montana

Curated by ChEMBL
LigandPNGBDBM50494112(CHEMBL2441475)
Affinity DataKi:  7.5nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK293 cells after 1.5 hrs by microbeta liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231593(CHEMBL4068469)
Affinity DataKi:  9.60nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50582415(CHEMBL5093654)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]ZM241385 from human A2A receptor expressed in HEK293 cell membranes measured after 3 hrs by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(RAT)
Otsuka Maryland Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM50013515((+)-yohimbine | (16alpha,17alpha)-17-hydroxyyohimb...)
Affinity DataKi:  10.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231710(CHEMBL4101044)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)
Affinity DataKi:  11nMAssay Description:Binding affinity to Androgen receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232995((R)-(+)-exo-2-norbonyl-N-n-butylcarbamate)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231715(CHEMBL4088084)
Affinity DataKi:  12nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50231592(CHEMBL4078636)
Affinity DataKi:  12nMAssay Description:Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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