Affinity DataKi: 0.0130nMAssay Description:Inhibition of DHFR (unknown origin) at pH 6.7More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Inhibition of thymidylate synthase (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 7.20nMAssay Description:Inhibition of DHFR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataKi: 65nMAssay Description:Inhibition of GARFT (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using pEY (4:1) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK in human DOHH-2 cells preincubated for 1 hr followed by compound washout and anti-IgG stimulation for 2 mins by chemiluminescence b...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human wild type EGFR using pEY (4:1) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR in human A-431 cells membrane incubated for 8 mins in presence of ATP by colorimetry assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of p110delta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of p110delta (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.80nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged EGFR (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 6.5nMAssay Description:Inhibition of TRKA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.10nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:Inhibition of TRKB (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9.20nMAssay Description:Inhibition of EGFR DEL19 mutant in human HCC827 cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human GST-tagged EGFR L858R/T790M double mutant using pEY (4:1) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R/T790M double mutant in human NCI-H1975 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of TRKC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of CYP3A4 in in human liver microsomes at incubated for 10 mins in presence of CYP3A4 substrate/NADP+ by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human CYP3A4 preincubated for 10 mins followed by substrate and NADP addition measured after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of BTK autophosphorylation in anti-IgG stimulated human DOHH-2 cells preincubated for 1 hr followed by compound washout and anti-IgG stimu...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of HER2 (unknown origin) using pEY (4:1) as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of EGF stimulated EGFR autophosphorylation in human HN5 cells incubated for 24 hrs by Western blotting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of p110gamma (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of EGFR in human A-431 cells membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged ERBB2 (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 74nMAssay Description:Inhibition of GST-tagged ERBB4 (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Zhengzhou University
Curated by ChEMBL
Zhengzhou University
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR3 (unknown origin) by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ...More data for this Ligand-Target Pair