Compile Data Set for Download or QSAR
maximum 50k data
Found 536 with Last Name = 'chen' and Initial = 'yt'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Brown University

Curated by ChEMBL
LigandPNGBDBM50102186((Difluoro-phenyl-methyl)-phosphonic acid | CHEMBL5...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory activity against Yersinia Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Brown University

Curated by ChEMBL
LigandPNGBDBM50102187(CHEMBL299446 | Furan-2-yl-oxo-acetic acid)
Affinity DataKi:  7.90E+4nMAssay Description:Inhibitory activity against Yersinia Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Brown University

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)
Affinity DataKi:  1.79E+5nMAssay Description:Inhibitory activity against Yersinia Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50241089(2-(ethyl(3-(4-(5-(2-(3-fluorophenylamino)-2-oxoeth...)
Affinity DataIC50:  0.370nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324585(CHEMBL1215022 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50026330(CHEMBL1684210)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50430377(CHEMBL2333898)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50026347(CHEMBL1684197)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324574((R)-6-Methoxy-N-(2-((1-methylpiperidin-4-yl)methox...)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50430374(CHEMBL2334292)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50026332(CHEMBL1684209)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338718(2-(6-fluorochroman-3-yl)-8-methoxy-6-(1H-pyrazol-4...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50026327(CHEMBL1684206)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338722(8-methoxy-2-((3-methoxyphenoxy)methyl)-6-(1H-pyraz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50026328(CHEMBL1684207)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338703(CHEMBL1684208 | N-cyclopropyl-3-(4-oxo-6-(1H-pyraz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50026346(CHEMBL1684201)
Affinity DataIC50: <1nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324604(CHEMBL1215021 | N-(4-(1H-Pyrazol-4-yl)phenyl)-2-am...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338695(2-(chroman-2-yl)-6-(1H-pyrazol-4-yl)quinazolin-4(3...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338714(8-methoxy-2-(6-methoxychroman-3-yl)-6-(1H-pyrazol-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338698(2-(6-methoxychroman-3-yl)-6-(1H-pyrazol-4-yl)quina...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338721(2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-8-methoxy-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50430355(CHEMBL2333899)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324592((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50430374(CHEMBL2334292)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50430356(CHEMBL2333897)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256322(CHEMBL482336 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256436(CHEMBL481735 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256384(6-chloro-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256383(CHEMBL481545 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50246409(CHEMBL455658 | N-(4-(1H-pyrazol-4-yl)phenyl)-3,4-d...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256067(CHEMBL481685 | N3-(4-(1H-pyrazol-4-yl)phenyl)-N6-(...)
Affinity DataIC50: <2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM25472(CHEMBL519123 | N-[4-(1H-pyrazol-4-yl)phenyl]-2,3-d...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50430339(CHEMBL2333879)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256069(6-methoxy-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256382(6-fluoro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256166(CHEMBL475601 | N-(4-(1H-pyrazol-4-yl)phenyl)-6-met...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338701(2-(6-fluorochroman-3-yl)-6-(1H-pyrazol-4-yl)quinaz...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338713(3-(4-(2-(dimethylamino)ethylthio)-6-(1H-pyrazol-4-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50338712(3-(4-(2-(dimethylamino)ethylthio)-6-(1H-pyrazol-4-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324605((R)-N-(2-(2-(Dimethylamino)ethoxy)-5-fluoro-4-(1H-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50324602((R)-6-Methoxy-N-(2-(1-methylpiperidin-4-yloxy)-4-(...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256163(CHEMBL474425 | N-(2-(2-(dimethylamino)ethoxy)-4-(1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256385(6-chloro-N-(2-methoxy-4-(1H-pyrazol-4-yl)phenyl)ch...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256068(6-methoxy-N-(3-methoxy-4-(1H-pyrazol-4-yl)phenyl)c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50256111(CHEMBL480586 | N-(2-methoxy-4-(1H-pyrazol-4-yl)phe...)
Affinity DataIC50:  3nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Taiwan National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM31837(2,4-Bisanilinopyrimidine, 10 | Aurora Inhibitor, 3...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant GST-tagged N-terminal truncated human Aurora A (123 to 401 residues) expressed in Sf9 insect cell using tetra-LRRASLG pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCruzipain(Trypanosoma cruzi)
Scripps Florida

Curated by ChEMBL
LigandPNGBDBM50229129(4-Methyl-piperazine-1-carboxylic acid [(S)-1-((E)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Trypanosoma cruzi recombinant cruzain by fluorescence techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50430367(CHEMBL2333909)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50430372(CHEMBL2334294)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant 6-His-tagged ROCK2 expressed in baculovirus-infected Sf9 cells using LCB-AKRRRLSSLRA-NH2 as substrate after 25 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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