Affinity DataKi: 7nMAssay Description:Compound was evaluated for the alpha-Adrenoceptor pA2 blocking activity in vitro in rabbit thoracic aortaMore data for this Ligand-Target Pair
Affinity DataKi: 24nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S/T165A mutantMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Inhibition of human thymidylate synthase at 600 uM concentration of 5,10-CH2-H4PteGluMore data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of human thymidylate synthase at 600 uM concentration of 5,10-CH2-H4PteGluMore data for this Ligand-Target Pair
Affinity DataKi: 54nMAssay Description:Inhibition of wild-type HIV1 Reverse transcriptaseMore data for this Ligand-Target Pair
Affinity DataKi: 58nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Inhibition of HIV1 Reverse transcriptase T165A mutantMore data for this Ligand-Target Pair
Affinity DataKi: 85nMAssay Description:Competitive inhibition of the human thymidylate synthase at 600 uM of [dUMP]More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S mutantMore data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:Inhibition of HIV1 Reverse transcriptase T165A mutantMore data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:Inhibition of HIV1 Reverse transcriptase M184V mutantMore data for this Ligand-Target Pair
Affinity DataKi: 230nMAssay Description:Competitive inhibition of the human thymidylate synthase at 28 uM as Ki(slope) of 5,10-CH2-H4PteGluMore data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: 370nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S/T165A mutantMore data for this Ligand-Target Pair
Affinity DataKi: 480nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S/M184V mutantMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Inhibition of wild-type HIV1 Reverse transcriptaseMore data for this Ligand-Target Pair
Affinity DataKi: 640nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S/M184V mutantMore data for this Ligand-Target Pair
Affinity DataKi: 640nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S mutantMore data for this Ligand-Target Pair
Affinity DataKi: 730nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S/T165A/M184V mutantMore data for this Ligand-Target Pair
Affinity DataKi: 790nMAssay Description:Inhibition of HIV1 Reverse transcriptase M184V mutantMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity against thymidylate synthase from murine leukemia L1210More data for this Ligand-Target Pair
Affinity DataKi: 1.05E+3nMAssay Description:Inhibition of HIV1 Reverse transcriptase P119S/T165A/M184V mutantMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Compound was tested for the binding affinity to thymidine kinase from HSV-1 infected HeLa BuMore data for this Ligand-Target Pair
Affinity DataKi: 3.00E+3nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nMAssay Description:Compound was tested for the binding affinity to thymidine kinase from Varicella zoster virus infected human cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5.06E+3nMAssay Description:Binding affinity against HSV-1(KOS) thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+4nMAssay Description:Binding affinity against human enzyme thymidylate synthase derived from either HeLa or KB cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.50E+4nMAssay Description:Binding affinity against HSV-2(333) enzyme thymidine kinaseMore data for this Ligand-Target Pair
Affinity DataKi: 4.00E+4nMAssay Description:Inhibitory constant of thymidylate synthase was determined in human AML cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of N5, 10-CH2-H4PteGlu and fixed dUMP (100 uM)More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: 1.50E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of N5, 10-CH2-H4PteGlu and fixed dUMP (100 uM)More data for this Ligand-Target Pair
Affinity DataKi: 1.60E+5nMAssay Description:Compound was tested for the binding affinity to thymidine kinase from HeLa mitochondriaMore data for this Ligand-Target Pair
Affinity DataKi: 1.90E+5nMAssay Description:Inhibitory constant was measured on cytidine/deoxycytidine deaminaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.40E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+5nMAssay Description:Compound was tested for the binding affinity to thymidine kinase from HeLa cytosolMore data for this Ligand-Target Pair
Affinity DataKi: 7.00E+5nMAssay Description:Inhibitory activity against human thymidylate synthase with variable concentration of dUMP and fixed N5,10-CH2-H4PteGlu (200 uM)More data for this Ligand-Target Pair
Affinity DataKi: 1.60E+6nMAssay Description:Inhibitory constant was measured on cytidine/deoxycytidine deaminaseMore data for this Ligand-Target Pair
Affinity DataKi: 7.69E+6nMAssay Description:Inhibitory constant was measured on cytidine/deoxycytidine deaminaseMore data for this Ligand-Target Pair
Affinity DataKi: 2.51E+7nMAssay Description:Inhibitory constant was measured on cytidine/deoxycytidine deaminaseMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Wayne State University School Of Medicine
Curated by ChEMBL
Wayne State University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration of the compound against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by t...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Wayne State University School Of Medicine
Curated by ChEMBL
Wayne State University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibitory concentration of the compound against human immunodeficiency virus type 1 (HIV-1 strain IIIB RT) reverse transcriptase was determined by t...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Ability to inhibit thymidylate synthase derived from human leukemia K562 cellsMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of North Carolina At Chapel Hill
Curated by ChEMBL
University Of North Carolina At Chapel Hill
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:IC50 value of the compound was measured as DNA dependent DNA polymerase associated activity by using 0.05 units of radiolabeled template poly(rA)-oli...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of HDAC2 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assayMore data for this Ligand-Target Pair