BindingDB PrimarySearch

Found 290 with Last Name = 'chew' and Initial = 'ys'

Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

Ki: 440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair

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Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

BDBM50502433(CHEMBL4575866)

Ki: 3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair

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Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

BDBM50502434(CHEMBL4551647)

Ki: 3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair

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3D Structure (crystal)

Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50133870(CHEBI:78030 | CHEMBL3188386 | US10251893, Compound...)

IC50: 0.400nMAssay Description:Inhibition of porcupine (unknown origin)More data for this Ligand-Target Pair

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3D Structure (crystal)

Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257135(CHEMBL4080208)

IC50: 0.400nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170221(CHEMBL3806189)

IC50: 1nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257160(CHEMBL4096728)

IC50: 1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257143(CHEMBL4080021)

IC50: 1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233629(CHEMBL4080842)

IC50: 1nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233628(CHEMBL4088716)

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233636(CHEMBL4070649)

IC50: 2nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50133866(CHEMBL3633802)

IC50: 2.90nMAssay Description:Inhibition of porcupine (unknown origin)More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233635(CHEMBL4099279)

IC50: 4nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233630(CHEMBL4084739)

IC50: 5nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257141(CHEMBL4069295)

IC50: 6nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233633(CHEMBL4089128)

IC50: 7nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170222(CHEMBL3805771)

IC50: 7nMAssay Description:Inhibition of human recombinant RET expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257139(CHEMBL4104447)

IC50: 8nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170218(CHEMBL3804952)

IC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170223(CHEMBL3805330)

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257144(CHEMBL4066589)

IC50: 9nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL

BDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)

IC50: 9nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170217(CHEMBL3805114)

IC50: 10nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170221(CHEMBL3806189)

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233640(CHEMBL4098880)

IC50: 10nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Breakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170221(CHEMBL3806189)

IC50: 10nMAssay Description:Inhibition of BCR fused full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) expressed in baculovirus expression system using...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257142(CHEMBL4096529)

IC50: 11nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)

IC50: 11nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257145(CHEMBL4095609)

IC50: 11nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170215(CHEMBL3806261)

IC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170171(CHEMBL3805029)

IC50: 12nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257157(CHEMBL4103356)

IC50: 12nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Histone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL

BDBM50502427(CHEMBL4542517)

IC50: 12nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257128(CHEMBL4087906)

IC50: 12nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257138(CHEMBL4066796)

IC50: 12nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170216(CHEMBL3805956)

IC50: 14nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257136(CHEMBL4061069)

IC50: 15nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233639(CHEMBL4097104)

IC50: 15nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293-STF3A cells assessed as inhibition of Wnt signaling by measuring decrease in beta-cateni...More data for this Ligand-Target Pair

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Protein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50257137(CHEMBL4094309)

IC50: 15nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170222(CHEMBL3805771)

IC50: 16nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL

BDBM375525(4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-...)

IC50: 16nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair

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Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170221(CHEMBL3806189)

IC50: 20nMAssay Description:Inhibition of full length human recombinant N-terminal His-tagged ABL (2 to 1130 residues) T315I mutant expressed in baculovirus expression system us...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL

BDBM375513((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...)

IC50: 20nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170222(CHEMBL3805771)

IC50: 20nMAssay Description:Inhibition of human recombinant FLT3 expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair

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Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170221(CHEMBL3806189)

IC50: 20nMAssay Description:Inhibition of human recombinant FLT3 expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)

IC50: 20nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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Cytochrome P450 3A4(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50233639(CHEMBL4097104)

IC50: 20nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

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Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170221(CHEMBL3806189)

IC50: 21nMAssay Description:Inhibition of human recombinant VEGFR2 expressed in sf21 cells using Poly(Glu:Tyr) as substrate in presence of [gamma32P]ATPMore data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

BDBM50170219(CHEMBL3805074)

IC50: 22nMAssay Description:Inhibition of N-terminal GST-tagged MNK2 kinase domain (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cells using JH3 ...More data for this Ligand-Target Pair

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MAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency For Science, Technology And Research (A*Star)

Curated by ChEMBL

BDBM375522(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)

IC50: 23nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 290 total ) | Next | Last >>

Filter my 290 hits

Targets 20▿
- MAP kinase-interacting serine/threonine-protein kinase 2 48
- MAP kinase-interacting serine/threonine-protein kinase 1 48
- Protein-serine O-palmitoleoyltransferase porcupine 38
- Histone-lysine N-methyltransferase SMYD3 30
- Cytochrome P450 3A4 28
- Cytochrome P450 2D6 27
- MAP kinase-interacting serine/threonine-protein kinase 1/2 24
- Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 22
- Tyrosine-protein kinase ABL1 7
- Receptor-type tyrosine-protein kinase FLT3 2
- Mast/stem cell growth factor receptor Kit 2
- Proto-oncogene tyrosine-protein kinase receptor Ret 2
- Platelet-derived growth factor receptor beta 2
- Vascular endothelial growth factor receptor 2 2
- Platelet-derived growth factor receptor alpha 2
- Fibroblast growth factor receptor 2 2
- Cytochrome P450 1A2 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- Serine/threonine-protein kinase RIO2 1
- Potassium voltage-gated channel subfamily H member 2 1
- ...
Publications 5▿
- J Med Chem 59: 3063-78 (2016) 97
- J Med Chem 61: 4348-4369 (2018) 93
- J Med Chem 60: 6678-6692 (2017) 40
- ACS Med Chem Lett 10: 978-984 (2019) 30
- J Med Chem 58: 5889-99 (2015) 30
Institutions 3▿
- Experimental Therapeutics Centre 167
- Agency For Science, Technology And Research (A*Star) 93
- Experimental Drug Development Centre 30
Affinity: 0.40 to 7.5E+5 nM▿
- Ki 3
- IC50 285
- Kd 2
- Affinity ≤ nM
Xtal structures: 3
Docked structures: 0
Catalog Cmpds: 8