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Found 80 with Last Name = 'clutterbuck' and Initial = 'l'
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259240((5-(1-Benzyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259554((5-(1-Phenethyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259287((5-(1-(3,5-Dimethylbenzyl)-1H-indazol-3-yl)-1,2,4-...)
Affinity DataIC50:  62nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259243((5-(1-(3-Methylbenzyl)-1H-indazol-3-yl)-1,2,4-oxad...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259240((5-(1-Benzyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259557((5-(1H-Indazol-1-yl)-1,2,4-oxadiazol-3-yl)methanam...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259241((5-(2-Benzyl-2H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  315nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259555((5-(2-Phenethyl-2H-indazol-3-yl)-1,2,4-oxadiazol-3...)
Affinity DataIC50:  360nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259240((5-(1-Benzyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as change in membrane potential using MP-red voltage sensitve dyeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259618(3-[3-tert-Butoxycarbonylaminomethyl-1,2,4-oxadiazo...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  920nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259557((5-(1H-Indazol-1-yl)-1,2,4-oxadiazol-3-yl)methanam...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259241((5-(2-Benzyl-2H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as change in membrane potential using MP-red voltage sensitve dyeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259356(3-((3-(3-(Aminomethyl)-1,2,4-oxadiazol-5-yl)-1H-in...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259554((5-(1-Phenethyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3...)
Affinity DataIC50:  1.32E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  2.55E+3nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259585((5-(1-(3,4-Dimethoxyphenylsulfonyl)-1H-indazol-3-y...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  3.02E+3nMAssay Description:Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259240((5-(1-Benzyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of human recombinant CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259063(CHEMBL513130 | Tert-butyl(5-(1-(benzo[d][1,3]dioxo...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  3.32E+3nMAssay Description:Inhibition of human Nav1.6 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  3.54E+3nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259287((5-(1-(3,5-Dimethylbenzyl)-1H-indazol-3-yl)-1,2,4-...)
Affinity DataIC50:  3.73E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  3.77E+3nMAssay Description:Inhibition of human Nav1.8 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259243((5-(1-(3-Methylbenzyl)-1H-indazol-3-yl)-1,2,4-oxad...)
Affinity DataIC50:  3.96E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259555((5-(2-Phenethyl-2H-indazol-3-yl)-1,2,4-oxadiazol-3...)
Affinity DataIC50:  4.27E+3nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  4.58E+3nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  4.76E+3nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  4.82E+3nMAssay Description:Inhibition of human Nav1.7 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259063(CHEMBL513130 | Tert-butyl(5-(1-(benzo[d][1,3]dioxo...)
Affinity DataIC50:  4.86E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  5.64E+3nMAssay Description:Inhibition of human Nav1.7 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  5.66E+3nMAssay Description:Inhibition of human Nav1.8 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259112(CHEMBL511893 | Tert-butyl(5-(1-(4-acetamidobenzyl)...)
Affinity DataIC50:  5.92E+3nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  6.34E+3nMAssay Description:Inhibition of human Nav1.8 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  8.54E+3nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259618(3-[3-tert-Butoxycarbonylaminomethyl-1,2,4-oxadiazo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259586(1-(3-(3-(Aminomethyl)-1,2,4-oxadiazol-5-yl)-1H-ind...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259616(CHEMBL511760 | Tert-butyl(5-(1-acetyl-1H-indazol-3...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259241((5-(2-Benzyl-2H-indazol-3-yl)-1,2,4-oxadiazol-3-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259111(CHEMBL466278 | Tert-butyl(5-(1-(3-carbamoylbenzyl)...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259196(CHEMBL467110 | Tert-butyl(5-(1-(4-(1H-pyrazol-1-yl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259585((5-(1-(3,4-Dimethoxyphenylsulfonyl)-1H-indazol-3-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259112(CHEMBL511893 | Tert-butyl(5-(1-(4-acetamidobenzyl)...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008746(CHEMBL3236343)
Affinity DataIC50:  1.45E+4nMAssay Description:Inhibition of human Nav1.7 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  1.48E+4nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  1.53E+4nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50008746(CHEMBL3236343)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50259018(CHEMBL467283 | Tert-butyl(5-(1-(3-methylbenzyl)-1H...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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