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Found 150 with Last Name = 'cole' and Initial = 'pa'
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011771(13-Methyl-10-thiiranyl-1,6,7,8,9,10,11,12,13,14,15...)
Affinity DataKi:  1nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014307(10-Difluoromethyl-13-methyl-1,6,7,8,9,10,11,12,13,...)
Affinity DataKi:  1nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM10044((2S,15S)-15-methyl-2-[(methylsulfanyl)methyl]tetra...)
Affinity DataKi:  1nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014316(7-(4-Azido-phenylsulfanyl)-10,13-dimethyl-1,6,7,8,...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014316(7-(4-Azido-phenylsulfanyl)-10,13-dimethyl-1,6,7,8,...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM8611(4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonit...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014299(2,2,10,13-Tetramethyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014310(13-Methyl-10-vinyl-1,6,7,8,9,10,11,12,13,14,15,16-...)
Affinity DataKi:  3nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014302(10,13-Dimethyl-3-methylene-1,2,3,6,7,8,9,10,11,12,...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014319(9-Hydroxy-2-phenyl-benzo[h]chromen-4-one | CHEMBL3...)
Affinity DataKi:  5nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101694(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  6nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101699(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  7nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011774(13-Methyl-10-oxiranyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  7nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014311(10-Ethyl-13-methyl-1,6,7,8,9,10,11,12,13,14,15,16-...)
Affinity DataKi:  9nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014309(7-(4-Iodo-phenylsulfanyl)-10,13-dimethyl-1,6,7,8,9...)
Affinity DataKi:  12nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014323(2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE | 2-Phenyl-benzo...)
Affinity DataKi:  20nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101705(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  21nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014320(8-Chloro-5-(4-chloro-phenyl)-5H-indeno[1,2-d]pyrim...)
Affinity DataKi:  24nMAssay Description:Binding affinity for Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Rattus norvegicus)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014324(5-[Bis-(4-chloro-phenyl)-methyl]-pyrimidine | 5-[B...)
Affinity DataKi:  29nMAssay Description:Binding affinity for Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101697(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  32nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

LigandPNGBDBM85108(AANAT bisubstrate analog, 3)
Affinity DataKi:  32nM ΔG°:  -43.5kJ/molepH: 6.8 T: 2°CAssay Description:AANAT activity was measured using a spectrophotometric assay in which the enzymatic product CoASH concentration were determined indirectly by monitor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50332807((8R,9S,10R,13S,14S)-10,13-dimethyl-2,3,7,8,9,10,11...)
Affinity DataKi:  37nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014308(4-Amino-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15...)
Affinity DataKi:  37nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101695(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  48nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

LigandPNGBDBM85109(AANAT bisubstrate analog, 1)
Affinity DataKi:  48nM ΔG°:  -42.5kJ/molepH: 6.8 T: 2°CAssay Description:AANAT activity was measured using a spectrophotometric assay in which the enzymatic product CoASH concentration were determined indirectly by monitor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50240798((8R,9S,10R,13S,14S)-4-Hydroxy-10,13-dimethyl-1,6,7...)
Affinity DataKi:  50nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101700(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  52nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50014312(13-Methyl-10-propenyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  56nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113742(N-[4-(2-Hydrazinylethyl)phenyl]-4-phenylbutanamide...)
Affinity DataKi:  59nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101706(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  59nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101699(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  65nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

LigandPNGBDBM85110(AANAT bisubstrate analog, 2)
Affinity DataKi:  67nM ΔG°:  -41.6kJ/molepH: 6.8 T: 2°CAssay Description:AANAT activity was measured using a spectrophotometric assay in which the enzymatic product CoASH concentration were determined indirectly by monitor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101702(Bisubstrate Analogue | [5-(6-amino-9H-purin-9-yl)-...)
Affinity DataKi:  67nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011770(13-Methyl-10-thiiranyl-1,6,7,8,9,10,11,12,13,14,15...)
Affinity DataKi:  75nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50011775(13-Methyl-10-oxiranyl-1,6,7,8,9,10,11,12,13,14,15,...)
Affinity DataKi:  75nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113753(N-[4-(2-Hydrazinylethyl)phenyl]-4-(1H-indol-3-yl)b...)
Affinity DataKi:  100nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113750((2E)-N-[4-(2-Hydrazinylethyl)phenyl]-3-phenylprop-...)
Affinity DataKi:  100nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113745(4-(4-Fluorophenyl)-N-[4-(2-hydrazinylethyl)phenyl]...)
Affinity DataKi:  138nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113744(4-(4-Chlorophenyl)-N-[4-(2-hydrazinylethyl)phenyl]...)
Affinity DataKi:  156nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50421878(CHEMBL2311178)
Affinity DataKi:  180nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113748(2-(3-{[4-(2-Hydrazinylethyl)phenyl]amino}-3-oxopro...)
Affinity DataKi:  204nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113746(N-[4-(2-Hydrazinylethyl)phenyl]-4-(4-methoxyphenyl...)
Affinity DataKi:  207nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113752(N-[4-(2-Hydrazinylethyl)phenyl]-3-(1H-indol-3-yl)p...)
Affinity DataKi:  210nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113749(3-(3-{[4-(2-Hydrazinylethyl)phenyl]amino}-3-oxopro...)
Affinity DataKi:  223nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113741(N-[4-(2-Hydrazinylethyl)phenyl]-3-phenylpropanamid...)
Affinity DataKi:  260nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113743(N-[4-(2-Hydrazinylethyl)phenyl]-5-phenylpentanamid...)
Affinity DataKi:  260nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Ovis aries)
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50101698(Bisubstrate Analogue)
Affinity DataKi:  275nMAssay Description:Inhibition of serotonin N-acetyl-transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113739(N-[4-(2-Hydrazinylethyl)phenyl]benzamide dihydroch...)
Affinity DataKi:  280nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Johns Hopkins University

LigandPNGBDBM113747(N-[4-(2-Hydrazinylethyl)phenyl]-4-(4-nitrophenyl)b...)
Affinity DataKi:  282nMpH: 7.5Assay Description:Reactions (100 µL) were initiated by the addition of 2 µL of GST-LSD1 (final concentration 96-154 nM). The reaction mixture contained 50 mM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin N-acetyltransferase(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

LigandPNGBDBM85112(AANAT bisubstrate analog, 5)
Affinity DataKi:  310nM ΔG°:  -37.8kJ/molepH: 6.8 T: 2°CAssay Description:AANAT activity was measured using a spectrophotometric assay in which the enzymatic product CoASH concentration were determined indirectly by monitor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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