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Found 79 with Last Name = 'combrink' and Initial = 'kd'
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004422(CHEMBL3238167)
Affinity DataIC50:  24nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004423(CHEMBL3238168)
Affinity DataIC50:  36nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  58nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004421(CHEMBL3238166)
Affinity DataIC50:  65nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004419(CHEMBL3238164)
Affinity DataIC50:  68nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004420(CHEMBL3238165)
Affinity DataIC50:  75nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004418(CHEMBL3238163)
Affinity DataIC50:  76nMAssay Description:Inhibition of truncated ROCK-2 (unknown origin) after 60 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004422(CHEMBL3238167)
Affinity DataIC50:  105nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50319005((R)-4-(1-aminoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4...)
Affinity DataIC50:  120nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004423(CHEMBL3238168)
Affinity DataIC50:  140nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004421(CHEMBL3238166)
Affinity DataIC50:  203nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004418(CHEMBL3238163)
Affinity DataIC50:  288nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004420(CHEMBL3238165)
Affinity DataIC50:  346nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50004419(CHEMBL3238164)
Affinity DataIC50:  350nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Alcon Laboratories

Curated by ChEMBL
LigandPNGBDBM50309126(2-(4-(6-(pyridin-4-yl)-3-(pyrrolidin-1-yl)pyrazin-...)
Affinity DataIC50:  570nMAssay Description:Inhibition of truncated ROCK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042857(CHEMBL3354494)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human recombinant Cathepsin S using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068280(5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trio...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibitory activity was measured against human leukocyte elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50461550(CHEMBL2403888)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068284(3-Benzyloxycarbonylamino-propionic acid 1,1,3-trio...)
Affinity DataIC50:  2.26E+3nMAssay Description:Inhibitory activity was measured against human leukocyte elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068298(4-Benzyloxycarbonylamino-benzoic acid 1,1,3-trioxo...)
Affinity DataIC50:  2.66E+3nMAssay Description:Inhibitory activity was measured against human leukocyte elastase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042857(CHEMBL3354494)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042857(CHEMBL3354494)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of human recombinant Cathepsin B using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042857(CHEMBL3354494)
Affinity DataIC50:  9.50E+3nMAssay Description:Inhibition of human recombinant Cathepsin K using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042856(CHEMBL3354495)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1/Trypsin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068280(5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trio...)
Affinity DataIC50: >1.20E+4nMAssay Description:Inhibitory activity was measured against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042856(CHEMBL3354495)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of human recombinant Cathepsin C using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042856(CHEMBL3354495)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of human recombinant Cathepsin K using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042856(CHEMBL3354495)
Affinity DataIC50:  2.40E+4nMAssay Description:Inhibition of human recombinant Cathepsin S using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068298(4-Benzyloxycarbonylamino-benzoic acid 1,1,3-trioxo...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068284(3-Benzyloxycarbonylamino-propionic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068280(5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trio...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibitory activity was measured against plasmin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068280(5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1/Trypsin-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068284(3-Benzyloxycarbonylamino-propionic acid 1,1,3-trio...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibitory activity was measured against trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068280(5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068284(3-Benzyloxycarbonylamino-propionic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068284(3-Benzyloxycarbonylamino-propionic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against plasmin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068284(3-Benzyloxycarbonylamino-propionic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against urokinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50068280(5-Benzyloxycarbonylamino-pentanoic acid 1,1,3-trio...)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibitory activity was measured against urokinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042857(CHEMBL3354494)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of human recombinant Cathepsin C using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042852(CHEMBL3354498)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of human recombinant Cathepsin K using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042856(CHEMBL3354495)
Affinity DataIC50:  8.10E+4nMAssay Description:Inhibition of human recombinant Cathepsin B using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042854(CHEMBL3354497)
Affinity DataIC50:  9.50E+4nMAssay Description:Inhibition of human recombinant Cathepsin K using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042851(CHEMBL3354499)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin K using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042850(CHEMBL3354492)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042858(CHEMBL3354493)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042855(CHEMBL3354496)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042854(CHEMBL3354497)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042852(CHEMBL3354498)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin L using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50042858(CHEMBL3354493)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant Cathepsin B using fluorogenic peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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